Hydrogen Breath Testing in Adults

Lindberg, Deborah

doi:10.1097/sga.0b013e3181da8b3a

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…The purest and currently the most meaningful breath analysis diagnostic compounds are the diatomic nitric oxide (inflammation in asthma) [49,[53][54][55], hydrogen (gastrointestinal disorders such as carbohydrate intolerance and malabsorption and intestinal bacteria overgrowth) [56] and carbon monoxide (smoking) [57]. There is a powerful case to add to this short list the triatomic hydrogen cyanide (HCN) as a discreet biomarker of lung infection by the bacterium Pseudomonas aeruginosa [58] and possibly acetonitrile (CH 3 CN) as a further marker of smoking [59,60].…”

Section: Acquisition Of Data and Its Interpretationmentioning

confidence: 99%

Pitfalls in the analysis of volatile breath biomarkers: suggested solutions and SIFT–MS quantification of single metabolites

Smith¹,

Španěl²

2015

J. Breath Res.

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The experimental challenges presented by the analysis of trace volatile organic compounds (VOCs) in exhaled breath with the objective of identifying reliable biomarkers are brought into focus. It is stressed that positive identification and accurate quantification of the VOCs are imperative if they are to be considered as discreet biomarkers. Breath sampling procedures are discussed and it is suggested that for accurate quantification on-line real time sampling and analysis is desirable. Whilst recognizing such real time analysis is not always possible and sample collection is often required, objective recognition of the pitfalls involved in this is essential. It is also emphasized that mouth-exhaled breath is always contaminated to some degree by orally-generated compounds and so, when possible, analysis of nose-exhaled breath should be performed. Some difficulties in breath analysis are mitigated by the choice of analytical instrumentation used, but no single instrument can provide solutions to all the analytical challenges. Analysis and interpretation of breath analysis data, however acquired, needs to be treated circumspectly. In particular, the excessive use of statistics to treat imperfect mass spectrometry/mobility spectra should be avoided, since it can result in unjustifiable conclusions. It is should be understood that recognition of combinations of VOCs in breath that, for example, apparently describe particular cancer states, will not be taken seriously until they are replicated in other laboratories and clinics. Finally, the inhibiting notion that single biomarkers of infection and disease will not be identified and utilized clinically should be dispelled by the exemplary and widely used single biomarkers NO and H 2 and now, as indicated by recent SIFT-MS results, HCN and perhaps pentane and acetic acid.Hopefully, these discoveries will provide encouragement to research workers to be more open-minded on this important and desirable issue.2

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Section: Acquisition Of Data and Its Interpretationmentioning

confidence: 99%

Pitfalls in the analysis of volatile breath biomarkers: suggested solutions and SIFT–MS quantification of single metabolites

Smith¹,

Španěl²

2015

J. Breath Res.

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Carbon Nanotube Based Gas Sensors toward Breath Analysis

Ellis

Star

2016

ChemPlusChem

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Breath analysis is a promising method for rapid, inexpensive, noninvasive disease diagnosis and health monitoring owing to the correlative relationship between breath biomarker concentrations and abnormal health conditions. However, current methods to identify and quantify breath components rely on large, bench‐top analytical instruments. Carbon nanotube (CNT)‐based gas sensors are desirable candidates to replace benchtop instruments because of their sensitive chemical‐to‐electrical transducer capability, high degree of chemical functionality options, and potential for miniaturization. This review seeks to give an overview of the synthetic methods used to functionalize CNT‐based gas sensors, specifically those sensors that target biologically relevant breath markers. Specific examples are provided to highlight the sensing mechanisms behind different classes of CNT hybrid composites. Finally, the current challenges and prospective solutions of applying CNT‐based sensors to breath analysis are discussed.

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Hydrogen Breath Testing in Adults

Cited by 2 publications

References 15 publications

Pitfalls in the analysis of volatile breath biomarkers: suggested solutions and SIFT–MS quantification of single metabolites

Pitfalls in the analysis of volatile breath biomarkers: suggested solutions and SIFT–MS quantification of single metabolites

Carbon Nanotube Based Gas Sensors toward Breath Analysis

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