Sesquiterpenoids from roots of Taraxacum laevigatum and Taraxacum disseminatum

Zielińska, Klaudia; Kisiel, Wanda

doi:10.1016/s0031-9422(00)00088-1

Cited by 25 publications

(9 citation statements)

References 7 publications

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“…Several medicinal compounds have been isolated from the roots of these plants, including the guaianolide, desacetylmatricarin, and the germacranolides, taraxinic acid, b-glucopyranosyl ester and sonchuside A (Ho et al, 1998;Zielin´ska and Kisiel, 2000). Two novel guaianolide glucosides (desacetylmatricarin 8-O-b-glucopyranoside and 11b-hydroxyleukodin 11-O-b-glucopyranoside) were also isolated (Michalska and Kisiel, 2003).…”

Section: Introductionmentioning

confidence: 99%

Agrobacterium tumefaciens-mediated transformation of a medicinal plant Taraxacum platycarpum

Bae

Park

Kwak

et al. 2005

Plant Cell Tiss Organ Cult

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Dandelion plants, the genus Taraxacum, are used in herbal medicine owing to their choleretic, diuretic and anti-carcinogenic activities and several medicinal compounds have been isolated from the roots of these plants. Metabolic manipulation of secondary metabolite biosynthesis is a potential strategy to improve the production of high-value secondary metabolites. The enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is known to control a key regulatory step in the isoprenoid pathway. We report an efficient transformation protocol for stable introduction of HMGR into dandelion plants (Taraxacum platycarpum H. Dablstaed), which is essential for the biotechnological approach. The Agrobacterium tumefaciens strain EHA105 containing the binary vector, pCAMBIA1301, with GUS and HMGR genes, showed high transformation efficiency after 3-5 week hygromycin selection. Southern blotting, GUS staining and RT-PCR analyses demonstrated stable integration of one copy of the HMGR gene into the dandelion genome. Expression of the integrated genes was particularly eminent in root tissues of primary transformant plants. The establishment of an efficient transformation method may facilitate the improvement of medicinal plant in terms of the accumulation levels of secondary metabolites.Abbreviations: BA -6-benzyladenine; GUSb-glucuronidase; HMGR -3-hydroxy-3-methylglutaryl-CoA reductase; MS -Murashige and Skoog; NAAa-naphthalene acetic acid Plant Cell, Tissue and Organ Culture (2005) 80: 51-57 Ó Springer 2005

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Section: Introductionmentioning

confidence: 99%

Agrobacterium tumefaciens-mediated transformation of a medicinal plant Taraxacum platycarpum

Bae

Park

Kwak

et al. 2005

Plant Cell Tiss Organ Cult

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“…Moreover, benzyl O-b-glucopyranoside has been isolated. Compounds 3 and 6 are known constituents of T. platycarpum [3] and T. bicorne [4] respectively, while the occurrence of 4 or 4 and 5 is hitherto confined to T. officinale [5], [6], T. linearisquameum [7], T. laevigatum, T. disseminatum [8], and T. bicorne [4]. Both 4 and 5 were found to be major constituents of an anti-leukotriene B 4 releasing fraction of T. officinale [9] and 5 also downregulated the cell surface expression of intercellular adhesion molecule-1 [10].…”

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confidence: 99%

Sesquiterpene Lactones fromTaraxacum obovatum

Michalska

Kisiel

2003

Planta med

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“…The structure of phytochemicals [2,17,25], supplemented with selected physicochemical values, was the basis for calculating by Fedors' method [12] Using the extraction medium polarity -ε h for water: ethanol extraction system and its solubility parameter δ…”

Section: Resultsmentioning

confidence: 99%

“…The above was the basis for the calculation, from the Hildebrand-Scatchard equation, the predicted solubility in water and in extraction mixtures with ethanol [15,16] by the mole fraction of the solubilized substance -log x 2 ; triterpenes, sesquiterpene lactones, derivatives of taraxacoside, taraxacolide β-D-glucoside and tetrahydroridentin B [17].…”

Section: Introductionmentioning

confidence: 99%

Solubility and solubilizing capabilities of aqueous solutions of Extractum Taraxaci e radix cum herba aqu. siccum in light of selected values of general Hildebrand-Scatchard-Fedors theory of solubility

Marczyński

Nowak

Jambor³

et al. 2016

Herba Polonica

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S u m m a r yIntroduction: The general Hildebrand-Scatchard theory of solubility supplemented by Fedors' solubility parameter -δ 1 2 = Σ Σ E V i i / was used to estimate the real solubility by -log x 2 (log of the mole fraction) of phytochemicals contained in Ext. Taraxaci e radix cum herba aqu. siccum. Surface activity of aqueous solution of extracts was determined and quantified -solubilizing capabilities of solutions of c exp. ≥cmc in relation to cholesterol particle size of Ø=1.00 mm, as well as of ketoprofen were defined. Objective: The calculated value -log x 2 collated with the polarity of extraction medium ε M allows to estimate the optimal solubility of phytochemicals that determine the viscosity of the aqueous extract of dandelion and above all its surface activity and the ability to solubilize lipophilic therapeutic agents (ketoprofen). Methods: Viscosity of water model solutions of dandelion extracts and exhibition solutions after the effective micellar solubilization of cholesterol and ketoprofen was measured using Ubbelohde viscometer in accordance with the Polish Standard. The surface tension of aqueous solutions of extract and exhibition solutions after solubilization of cholesterol and ketoprofen was measured according to the Polish Standard with stalagmometric method. Results: The calculated factual solubility, and mainly the determined and calculated hydrodynamic size mean, that despite the complex structure of the micelle, it solubilizes cholesterol (granulometric grain of diameter Ø=1.00 mm) and ketoprofen (state of technological fragmentation) in equilibrium conditions. Equilibrium solubilization of ketoprofen also occurs in an environment of model gastric juice (0.1 mol HCl). Conclusions: The obtained results indicate that after the administration (and/or dietary supplementation) with Ext. Taraxaci e radix cum herba aqu. siccum, the physiological parameters of gastric juice would not be measured and its presence (phytosurfactant) in the body of the duodenum (bile A) increases abilities of solubilizing lipophilic therapeutic agents and cholesterol accounting for its use in the treatment of liver diseases and cholesterol gall bladder stones.

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Sesquiterpenoids from roots of Taraxacum laevigatum and Taraxacum disseminatum

Cited by 25 publications

References 7 publications

Agrobacterium tumefaciens-mediated transformation of a medicinal plant Taraxacum platycarpum

Agrobacterium tumefaciens-mediated transformation of a medicinal plant Taraxacum platycarpum

Sesquiterpene Lactones fromTaraxacum obovatum

Solubility and solubilizing capabilities of aqueous solutions of Extractum Taraxaci e radix cum herba aqu. siccum in light of selected values of general Hildebrand-Scatchard-Fedors theory of solubility

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