Sesquiterpene Lactones fromTaraxacum obovatum

Abstract

Two new guaianolide glucosides, deacetylmatricarin 8-O-beta-glucopyranoside and 11beta-hydroxyleukodin 11-O-beta-glucopyranoside, were isolated from roots of Taraxacum obovatum, along with four known sesquiterpene lactones, deacetylmatricarin, sonchuside A, taraxinic acid beta-glucopyranosyl ester and its 11beta,13-dihydro derivative. Their structures were established by spectral methods.

Simultaneous determination of luteolin and luteoloside in dandelions using HPLC

“…In recent reports, the sesquiterpene lactones deacety lmatricarin and 2-oxo-guaianolides, which are unusual for this genus, were isolated from the dandelions (Ho et al, 1998;Kisiel and Michalska, 2006;Michalska and Kisiel, 2003). The dandelions were also found to include various triterpenes and phytosterols, such as taraxasterol, -taraxasterol, taraxasterol acetates and their hydroxy derivatives arnidol and faradiol, -and -amyrin, -sitosterol, -sitosterol-O-D-glucoside, and stigmasterol in T. officinale (Akashi et al, 1994;Hänsel et al, 1980).…”

Anti-inflammatory activity of Taraxacum officinale

“…Taraxacum japonicum exhibited strong anti-tumorpromoting activities on the two-stage carcinogenesis of mouse skin tumor induced by an initiator and a promoter, suggesting its chemopreventive activity (Takasaki et al, 1999). In the recent analysis, two new guaianolide glucosides, deacetylmatricarin 8-O-␤-glucopyranoside and 11␤-hydroxyleukodin 11-O-␤-glucopyranoside, were isolated from Taraxacum obovatum (Michalska and Kisiel, 2003), and taraxafolide and (+)-taraxafolin-B were newly identified from Taraxacum formosanum (Leu et al, 2005). Differences in constituents and pharmacological activities of various species in the genus Taraxacum remain obscure.…”

Eudesmanolides from Taraxacum mongolicum and their inhibitory effects on the production of nitric oxide

“…Taraxacum japonicum exhibited strong antitumor-promoting activities on the two-stage carcinogenesis of mouse skin tumor induced by an initiator and a promoter, suggesting its chemopreventive activity (Takasaki et al, 1999;Kisiel and Michalska, 2005). In the recent analysis, two new guaianolide glucosides, deacetyl-matricarin-8-O-β-glucopyranoside and 11β-hydroxyleukodin-11-O-β-glucopyranoside, were isolated from Taraxacum obovatum (Michalska and Kisiel, 2003), and taraxafolide and (+)-taraxafolin-B were newly identified from Taraxacum formosanum (Leu et al, 2005). Differences in constituents and pharmacological activities of various species of Taraxacum remain obscure.…”