Sesquiterpene Glucosides from Chloranthus japonicusSieb.

Abstract

A new lindenane sesquiterpene glucoside named yinxiancaoside A (1), a new, rare bidesmosidic megastigmane sesquiterpene glucoside named yinxiancaoside B (5), and three known sesquiterpene glucosides, chloranoside A (2), pisumionoside (3), and sarcaglaboside A (4), were isolated from the whole plant of Chloranthus japonicus Sieb. The structures of the new compounds were established by an extensive study of their spectral data, especially 1D- and 2D-NMR. The cytotoxic activity of the isolated compounds against human hepatoma (Hepg-2), human ovarian carcinoma (OV420), and human breast cancer (MCF-7) cells was investigated.

Gynostemosides A–E, megastigmane glycosides from Gynostemma pentaphyllum

“…In fact, various carotenoids have been detected in G. pentaphyllum (Liu et al, 2004b). Naturally occurring megastigmane derivatives were previously found to have anti-proliferative (Zhou et al, 2009;Liu et al, 2008;Janakiram et al, 2008;Chen et al, 2006;Liu et al, 2004c;Liu et al, 2004d;Duncan et al, 2004;Yu et al, 1995), anticancer (Ito et al, 2002;Jung et al, 1998), and cytotoxic effects (Kuang et al, 2008;Alija et al, 2006;Perrone et al, 2005;Kubo and Morimitsu, 1995). Our isolated compounds, however, were tested against human lung adenocarcinoma (A549, H460), human glioma (U251), human osteosarcoma (U2OS), and human breast (MCF-7) cancer cells using the MTT method (Wu et al, , 2010, but were inactive.…”

Lignan constituents from Chloranthus japonicus Sieb.

“…The tumor cell lines were Hepg-2 (human hepatoma cells), OV420 (ovarian carcinoma cells), and MCF-7 (breast cancer cells). Details of the cytotoxicity were provided in our previously published paper (Kuang et al, 2008).…”

Natural sesquiterpenoids

“…The b-ionone derivative 22 has been found in an ethanol extract of the aerial parts of Tridax procumbens, 26 whilst a novel sulfated norsesquiterpene of this type 23 has been isolated from the twigs and leaves of Laguncularia racemosa. 27 The megastigmane glucosides euodionosides A-G 24-30 and yinxiancaoside B 31 have been obtained from Euodia meliaefolia 28 and Chloranthus japonicus, 29 respectively. Another compound of this type 32 has been isolated from Acanthus ilicifolius, 30 whilst the glycosides 33 and 34 have been obtained from Liriosma ovata 31 and Aquilegia hybrida, 32 respectively.…”