Natural sesquiterpenoids

Abstract

This review covers the isolation, structural determination, synthesis and chemical and microbiological transformations of natural sesquiterpenoids. 421 references are cited.

Enhanced structural diversity in terpenoid biosynthesis: enzymes, substrates and cofactors

“…6,[10][11][12][13][14] These ubiquitous natural products have been identified from insects, microorganisms and plants of both terrestrial and marine origins. [15][16][17][18][19] Most terpenoids originate from plants and are known as precursors of many essential compounds like vitamins, hormones and medicines, apart from providing plants with their distinct fragrance and flavor properties. 20 Essentially all terpenoids are derived by the condensation of multiple units of IDP and its isomer DMADP ( Fig.…”

Inflammatory Inhibitory Activity of Sesquiterpenoids from <i>Atractylodes macrocephala</i> Rhizomes

“…Compound 3 (Table 1), which are typical of an eudesmene skeleton 27) with two hydroxyl groups, and an exocyclic double bond. These features were confirmed by the HMBC correlations between the two methyl signals at δ H 1.54 with δ C 76.3 (C-7) and 75.1 (C-11), and from the exocyclic protons at δ H 4.59 and 4.79 to δ C 37.6 (C-3), 152.1 (C-4) and 45.0 (C-5) (Fig.…”

Biological activity of natural sesquiterpenoids containing a gem-dimethylcyclopropane unit

“…Furthermore, the presence of a vicinal hydroxyl group at the C-2 position should have a trans disposition with respect the a-hydroxyl group at C-1 as is the case for nambinone C (4). The isomer rulepidadiol (5) with the a-hydroxyl group at C-2 was inactive.…”

“…Although sesquiterpenes [1][2][3][4][5][6] and diterpenes [7][8][9][10][11] have been the subject of numerous reviews, sesquiterpenes containing a gemdimethylcyclopropyl subunit need a comprehensive review because of the wide range of their potentially valuable biological activities and broad structural diversity.…”