Sesamin suppresses STZ induced INS-1 cell apoptosis through inhibition of NF-κB activation and regulation of Bcl-2 family protein expression

Protective effect of cirsimaritin against streptozotocin-induced apoptosis in pancreatic beta cells

“…Oxidative stress occurring at the onset of diabetes is considered one of the major causative factors. Excessive intracellular levels of ROS cause direct damage to pancreatic β cells exposed to STZ . In addition, exposure to STZ for 12 h has been shown to markedly increase the intracellular ROS in INS‐1 cells and result in a proinflammatory state with altered redox balance .…”

“…Earlier studies have shown that STZ induces significant apoptosis through the activation of caspase‐3, PARP, NF‐κB and regulation of the protein expression of BCL‐2 family members in INS‐1 cells . Apoptosis occurring at the onset of diabetes is considered a major causative factor.…”

“…The roots of Averrhoa carambola L. have been introduced to protect against STZ‐induced pancreatic β‐cell apoptosis in diabetic mice by inhibiting caspase‐3, caspase‐8, caspase‐9 and BAX and increasing the expression of the apoptosis suppressor BCL‐2 . Sesamin, a major lignin constituent in sesame seeds with potent antioxidant capacity, markedly suppressed NF‐κB activation, downregulated BAX protein and upregulated BCL‐2 protein in pancreatic β cells undergoing apoptosis induced by STZ . Pretreatment with resveratrol, a type of polyphenolic phytoalexin, markedly suppressed the caspase‐3 activation and poly (ADP‐ribose) polymerase (PARP) in the apoptosis of pancreatic β‐cells induced by STZ .…”

“…[10] Sesamin, a major lignin constituent in sesame seeds with potent antioxidant capacity, markedly suppressed NF-jB activation, downregulated BAX protein and upregulated BCL-2 protein in pancreatic b cells undergoing apoptosis induced by STZ. [1,11] Pretreatment with resveratrol, a type of polyphenolic phytoalexin, markedly suppressed the caspase-3 activation and poly (ADP-ribose) polymerase (PARP) in the apoptosis of pancreatic b-cells induced by STZ. [12] Fermented soy permeate and olive leaves have been shown to decrease inflammation as well as in vivo oxidative stress induced by STZ in type 1 diabetic rats.…”

Ethaselen: a novel organoselenium anticancer agent targeting thioredoxin reductase 1 reverses cisplatin resistance in drug-resistant K562 cells by inducing apoptosis

“…The Bcl-2 family members are intimately involved in the apoptosis, but the role of these proteins in drug-induced death is controversial, including anti-apoptotic proteins such as Bcl-2, Bcl-XL, and Bcl-W, and pro-apoptotic proteins such as Bax, Bad, Bid, and Bim (Chu, 1994;Bargou et al, 1995;Tilly et al, 1995;Tao et al, 1997;Hahn et al, 2003;Dumay et al, 2006;Heath-Engel et al, 2008;Tanaka et al, 2010;Chen et al, 2014;Zheng et al, 2015). It is certain that the Bcl-2 family of proteins is closely related to the regulation of cell death by inducing apoptosis, which is initiated by the release of cytochrome c from mitochondria.…”