Serum γ-glutamyl transpeptidase and physical exercise

Haralambie, G

doi:10.1016/0009-8981(76)90199-6

Cited by 27 publications

(9 citation statements)

References 20 publications

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“…The impact of exercise and caffeine on these enzymes could reflect a loss of hepatocyte or muscle cell membrane integrity with consequent leakage of the proteins into the blood. Concentrations of AP and cGT in the blood were not changed in any of the groups, in agreement with Haralambie's findings, 23 ruling out the possibility of hepatic injury. Thus the increase in plasma LDH, ALT, and AST suggests that the muscle lesions caused by exercise are enhanced by caffeine.…”

Section: Discussionsupporting

confidence: 90%

Effect of caffeine supplementation on haematological and biochemical variables in elite soccer players under physical stress conditions

Bassini-Cameron

Sweet²,

Bottino³

et al. 2007

Br J Sports Med

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Objective: To evaluate the effect of caffeine on white cell distribution and muscle injury markers in professional soccer players during exercise. Methods: 22 male athletes completed a placebo controlled double blind test protocol to simulate a soccer match, followed by a Yo-Yo intermittent recovery test. Results: Exercise caused an increase in packed cell volume that was enhanced by caffeine. Caffeine and exercise had a synergistic effect on the blood lymphocyte count, which increased by about 38% after exercise, and by an additional 35% when combined with caffeine. Caffeine promoted an exercise independent rise in circulating monocytes, and a synergistic action of exercise and caffeine was observed on segmented neutrophils. Caffeine promoted thrombocytosis. Plasma adenosine deaminase, aspartate aminotransferase, and lactate dehydrogenase concentrations were enhanced by exercise, and alanine transaminase concentration was enhanced in both groups, with a synergistic effect of caffeine. Conclusions: The pronounced increase in the white cell count in the group receiving caffeine appeared to be caused by greater muscle stress and consequently more intense endothelial and muscle cell injury. The use of caffeine may augment the risk of muscle damage in athletes.

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Section: Discussionsupporting

confidence: 90%

Effect of caffeine supplementation on haematological and biochemical variables in elite soccer players under physical stress conditions

Bassini-Cameron

Sweet²,

Bottino³

et al. 2007

Br J Sports Med

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“…It should be pointed out that GGT blood plasma activity is rarely analyzed for being exertional metabolic marker. Some literature data did not show the influence of physical effort on GGT activity changes in blood serum (13) and in the urine (1). However, other data indicate significant differences in urinary GTT level between pre-, post-, and 24 hours after training (2,31).…”

Section: Discussionmentioning

confidence: 99%

Could Biochemical Liver Profile Help to Assess Metabolic Response to Aerobic Effort in Athletes?

Chamera

Spieszny²,

Klocek

et al. 2014

Journal of Strength and Conditioning Research

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Monitoring and optimizing the effectiveness of training course require wide analyses of athletes' blood parameter changes. The aim of this study was to evaluate the usefulness of biochemical liver profile to assess the metabolic response to semi-long-distance outdoor run in football players. Sixteen football players run outdoor for 60 minutes to achieve aerobic metabolism. Plasma activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyltransferase (GGT) and plasma levels of total and direct bilirubin were determined in samples obtained before exercise test (pre-exercise) and immediately after the run (post-exercise). Mean AST plasma activity (U·L-1) before/after the exercise, respectively, was 78.3/228.3 in women and 76.5/56.2 in men. Mean ALT plasma activity (U·L-1) before/after the exercise, respectively, was 27.5/59.1 in women and 36.2/35.3 in men. Mean GGT plasma activity (U·L-1) before/after the exercise, respectively, was 39.3/76.6 in women and 44.7/71.2 in men. Plasma levels of total and direct bilirubin were similar before and after the run regardless of the gender. Statistical significance of the differences between results obtained pre- and post-exercise occurred in women (p = 0.0212 for AST; p = 0.0320 for ALT; p = 0.0067 for GGT, respectively). The training monitoring in athletes should be performed using measurements of performance and biological or physiological parameters. It was found that AST, ALT, and GGT activities could be a valuable tool to assess the metabolic response in high-level fitness female athletes. Therefore, monitoring of those well-known diagnostic markers could prevent the trainee from harmful overtraining.

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“…Haralambie (1976) There have been only a few reports (Ohno et al 1981) describing fluctuations in the serum y-GTP levels caused by long-term exercise or daily activity.…”

Section: Discussionmentioning

confidence: 99%