Serum Zinc Levels in Cutaneous Disorders

Pn, Arora; Dhillon, K. S.; Rajan, SR; Sayal, S K; Das, AL

doi:10.1016/s0377-1237(02)80083-1

Cited by 39 publications

(40 citation statements)

References 10 publications

(5 reference statements)

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“…The results of this study are consistent with the findings of Arora et al ’ s study that confirmed the role of zinc deficiency in certain diseases such as psoriasis, acne, vulgaris and leprosy [6]. Since lichen planus is a mucocutaneous disease and zinc has a substantial role in development of epithelium, ulceration in dermatologic diseases and simultaneous zinc deficiency in these diseases may endorse the role of this element on pathogenesis of lichen planus disease.…”

Section: Discussionsupporting

confidence: 92%

“…No significant alterations in the serum zinc levels were detected in cases of vitiligo and aphthous ulcers, compared to healthy individuals in the study of Arora et al [6]. It seems that the reason for this difference is the dissimilarity in type of involved autoimmune disease and the type of aphtus lesions (minor type) in their study which apparently could not influence the serum zinc level.…”

Section: Discussionmentioning

confidence: 73%

“…Deficiency of zinc leads to imbalance in T- helper lymphocytes (TH), the decrease in the number of TH1 lymphocytes will result in increasing TH2 as the reimbursement process .The increasing in the TH2 function is related to the formation of lichen planus, increasing cytotoxicity and lichen planus pathogenesis [5]. The findings of the Arora et al’s study indorse the role of zinc deficiency in psoriasis, acne vulgaris and leprosy [6]. Khademi et al [7] have also substantiated the lower serum zinc level in patients with recurrent aphthous stomatitis.…”

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical Evaluation of Ki-67 Expression in Erosive andNon-Erosive Oral Lichen Planus

Gholizadeh¹,

Mehdipour²,

Dadgar³

et al. 2016

Avicenna J Dent Res

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Statement of Problem: Lichen planus is a chronic inflammatory immunologic-based disease involving skin and mucosa. This disease is generally divided into two categories: erosive and non-erosive. Many etiologic factors are deliberated regarding the disease; however, the disorders of immune system and the role of cytotoxic T-lymphocytes and monocytes are more highlighted. Zinc is an imperative element for the growth of epithelium and its deficiency induces the cytotoxic activity of T-helper2 cells, which seems to be associated with lichen planus. Purpose: This study was aimed to evaluate the levels of serum zinc in erosive and non-erosive oral lichen planus (OLP) and to compare it with the healthy control group to find out any feasible inference. Materials and Method: A total of 22 patients with erosive oral lichen planus, 22 patients with non erosive OLP and 44 healthy individuals as the control group were recruited in this descriptive-comparative study. All the participants were selected from the referees to the department of oral medicine, school of dentistry, Tabriz University of Medical Sciences. Serum zinc level was examined for all the individuals with liquid-stat kit (Beckman Instruments Inc.; Carlsbad, CA). Data were analyzed by adopting the ANOVA and Tukey tests, using SPSS 16 statistical software. Results: The mean age of patients with erosive and non-erosive LP was 41.7 and 41.3 years, respectively. The mean age of the healthy control group was 34.4 years .The mean serum zinc levels in the erosive and non erosive lichen planus groups and control groups were 8.3 (1.15), 11.15 (0.92) and 15.74 (1.75) μg/dl respectively. The difference was statistically significant (p< 0.05). Conclusion: The serum zinc levels were decreased in patients with erosive oral lichen planus. This finding may probably indicate the promising role of zinc in development of oral lichen planus.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical Evaluation of Ki-67 Expression in Erosive andNon-Erosive Oral Lichen Planus

Gholizadeh¹,

Mehdipour²,

Dadgar³

et al. 2016

Avicenna J Dent Res

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“…Serum Cu and Zn were compared between the control and vitiligo patients, with vitiligo patients having significantly lower serum levels of both Cu and Zn compared to controls [34]. Although both of these studies indicate some relationship between serum Zn levels and vitiligo, other findings have determined no significant difference between Zn levels in vitiligo patients compared to controls, leaving this topic controversial [37].…”

Section: Minerals: Zinc and Coppermentioning

confidence: 99%

Assessment of Dietary Supplementation in the Treatment of Vitiligo

Smith¹,

Mohammad²,

Hamzavi³

2017

TODJ

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Background:Vitiligo is the most common acquired pigmentary disorder in the world. Due to alterations in physical appearance, vitiligo is a psychologically devastating disease. Although treatment options exist, a cure for this disease has yet to be discovered. Of recent interest in vitiligo is the relationship between diet and disease. Objective:To review various dietary modifications and supplementation used in the management of vitiligo. Materials and Methods:A thorough evaluation of recent literature using the keywords "vitiligo, diet, supplement, antioxidant, vitamin, mineral, zinc, copper, gluten-free, celiac disease, alternative medicine" in the NCBI PubMed search function was performed. Results:A total of 39 relevant articles were reviewed and critically evaluated. Conclusion:Initial studies regarding the treatment of vitiligo through dietary modification are promising, although further studies are needed in multiple populations to explore the therapeutic value of these interventions.

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“…Arora et al did not find any significant alteration in serum Zn levels in vitiligo patients [122]. On the other hand, in another study Helmy et al reported that serum Zn and Cu levels were significantly higher in active vitiligo patients secondary to their release from the peripheral blood mononuclear cells due to apoptosis [123].…”

Section: Vitiligomentioning

confidence: 99%