An overview of zinc and its importance in dermatology-Part II: The association of zinc with some dermatologic disorders

“…The results of this study are not in line with a study by Rostami Mogaddam et al, which reported 45.8% of patients in the melasma group to have low serum zinc levels compared to 23.7% of patients in the control group. Zinc appears to be effective in treating melasma due to its role as an anti-inflammatory, antioxidant, anti-peeling agent, and as one of the common ingredients of sunscreen (25). The relationship of serum zinc levels to melasma is controversial.…”

Section: Resultsmentioning

confidence: 99%

A comparison of serum zinc levels in melasma and non-melasma patients: a preliminary study of thyroid dysfunction

Sekarnesia

Sitohang

Agustin

et al. 2020

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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Introduction. Melasma is an acquired hyperpigmentation disorder, clinically identified by symmetrical blackish-brown macules, especially on the facial area. Several factors are thought to play a role, including thyroid dysfunction and zinc deficiency. The aim of this study was to determine serum zinc levels in melasma and non-melasma patients with and without thyroid dysfunction. Methods. A cross-sectional study was conducted in Jakarta in September 2019. There were 60 melasma patients and 60 nonmelasma patients. The two groups were matched for age and sex. Atomic absorption spectrophotometry was used to measure serum zinc levels. Blood laboratory tests were used to check thyroid function by measuring thyroid stimulating hormone and free T4. Statistical analysis was performed using SPSS software. Results. The mean serum zinc level in the melasma group was 10.25 ± 1.89 μmol/l and in the non-melasma group 10.29 ± 1.46 μmol/l (p < 0.901). The mean serum zinc level in melasma patients with thyroid dysfunction was 8.77 ± 0.69 μmol/l, in melasma patients without thyroid dysfunction 10.33 ± 1.89 μmol/l, in non-melasma patients with thyroid dysfunction 10.48 ± 2.4 μmol/l, and in non-melasma patients without thyroid dysfunction 10.27 ± 1.4 μmol/l (p < 0.184). Conclusions. There was no significant difference between serum zinc levels in the melasma and non-melasma groups with and without thyroid dysfunction.

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“…31 The effect of zinc on cutaneous lichen planus has been the subject of some research. 43 Thomas et al 44 studied the efficacy of combining topical zinc sulfate with clobetasol propionate cream compared to clobetasol propionate cream monotherapy in the treatment of cutaneous lichen planus and reported that the combination was significantly more effective in treating the lesions, especially in the long term.…”

Section: Discussionmentioning

confidence: 99%

Effect of zinc supplementation as an adjuvant to corticosteroid treatment in patients with oral lichen planus: A systematic review

Bahramian,

Rahbaran,

Bahramian

et al. 2023

J Adv Periodontol Implant Dent

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Background. Oral lichen planus (OLP) and one of its main presentations, desquamative gingivitis, are common diseases with no definite treatment. Zinc deficiency has a critical role in the pathogenesis of oral mucosal diseases. The current study systematically reviewed the effect of zinc in addition to topical corticosteroids in the treatment of OLP. Methods. English articles in PubMed, Web of Sciences, Embase, and Scopus were searched until August 2022. The differences in symptoms were analyzed, including pain, burning sensation, and lesion sizes in patients with lichen planus receiving zinc supplementation as an adjuvant to corticosteroid treatment. Results. A total of 148 articles related to the searched keywords were found. Eventually, two clinical trials were selected. The total population of studied individuals included 60 patients. Due to the high heterogeneity between the studies, meta-analysis was not possible. Administering zinc, in addition to corticosteroids, did not improve the symptoms compared to corticosteroid monotherapy. Conclusion. Considering the limited number of studies and lack of sufficient evidence, it is not currently possible to reach a definite conclusion regarding the effects of zinc on OLP.

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An overview of zinc and its importance in dermatology-Part II: The association of zinc with some dermatologic disorders

Cited by 9 publications

References 84 publications

Zinc Therapy in Treatment of Symptomatic Oral Lichen Planus

Zinc Therapy in Treatment of Symptomatic Oral Lichen Planus

A comparison of serum zinc levels in melasma and non-melasma patients: a preliminary study of thyroid dysfunction

Effect of zinc supplementation as an adjuvant to corticosteroid treatment in patients with oral lichen planus: A systematic review

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