Serum vitamin D level may be a novel potential risk factor for premature ejaculation: a comparative study

Aal, Abd El; Sf, GamalEl Din; La, Rashed; Aerb, Tawfik; Ms, ElSheemy

doi:10.1007/s11255-018-1975-x

Cited by 9 publications

(5 citation statements)

References 30 publications

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“…Finally, PEDT was used to confirm the diagnosis of LPE in the current study although it is not validated in Arabic. However, it was utilized in a previous study to confirm the diagnosis of LPE among Egyptian patients where vitamin D level was estimated among them (Abd El Aal et al, 2018). Third, the miRNA analyses were replicated once per patient's sample for each miRNA due to financial limitations.…”

Section: Discussionmentioning

confidence: 99%

Study of the role of microRNAs 16 and 135a in patients with lifelong premature ejaculation receiving fluoxetine daily for 3 months: A prospective case control study

et al. 2022

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We aimed to determine the level of miRNAs 16 and 135a in lifelong premature ejaculation (LPE) patients versus controls. Moreover, we evaluated the potential interplay between the studied miRNAs and fluoxetine in these patients after utilizing fluoxetine daily for 3 months. The study involved 60 consecutive LPE patients and 20 healthy age matched individuals as controls. The median miRNA16 was significantly higher in the controls (1.02) compared to the patients (0.31) (p < 0.001). Moreover, the median miRNA‐135a was significantly higher in the controls compared to the patients 1.02 and 0.35, p < 0.001, respectively. In addition, the median pre‐treatment miRNA16 in the responders was 0.29 that significantly increased to 0.66 (p < 0.001). The median pre‐treatment miRNA‐135a in the responders was 0.27 that significantly increased to 0.65 (p < 0.001). Furthermore, considering EXP(β) for the odds ratio evaluation, with a 95% degree of confidence, a 1 fold increase in pre‐treatment miRNA 135a fold change decreases the odds for being responsive to SSRI by 0.028. Meanwhile, there was non‐significant association between fluoxetine responsiveness and age, pre‐treatment miRNA 16, pre‐treatment PEDT and pre‐treatment IELT. The current study had shown that a lower pre‐treatment miRNA 135a was significantly associated with response to fluoxetine.

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Section: Discussionmentioning

confidence: 99%

Study of the role of microRNAs 16 and 135a in patients with lifelong premature ejaculation receiving fluoxetine daily for 3 months: A prospective case control study

et al. 2022

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“…Abd El Aal et al [ 91 ] investigated vitamin D deficiency in a sample of 40 men with LPE and 40 healthy controls. They detected vitamin D deficiency in 16 (20%) of the participants, all of whom had LPE.…”

Section: Vitamin D Deficiencymentioning

confidence: 99%

Premature Ejaculation and Endocrine Disorders: A Literature Review

Coşkuner

Ozkan

2022

World J Mens Health

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Premature ejaculation (PE) is the most common male sexual dysfunction, with 30% of men experiencing PE worldwide. According to the generally accepted classification, there are two types of PE: lifetime PE and acquired PE. Various biological and psychological causes are known to be involved in the etiology of PE. However, due to the incomplete definition and etiopathogenesis of PE, there is no effective treatment. Although clinical and animal studies indicate that hormones play a role in controlling the ejaculation process, the precise endocrine mechanisms are unclear. In addition, little is known about the role of endocrine disorders in PE etiology. However, there is evidence that diabetes mellitus (DM), obesity, metabolic syndrome (MetS), thyroid gland disorders, pituitary gland disorders, and vitamin D deficiency affect the prevalence of PE. Moreover, it has been reported that the prevalence of PE decreases with treatment of these endocrine disorders. In this review, the relationship between PE and DM, MetS, obesity, vitamin D deficiency, and thyroid and pituitary gland disorders is summarized.

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“…Canat et al [ 24 ] reported lower levels of vitamin D in patients with APE than in a control group. Abd El Aal et al [ 25 ] found similar results in patients with LPE. Moreover, both studies reported the serum vitamin D level to be an important risk factor for PE.…”

Section: Discussionmentioning

confidence: 62%

The association of reproductive hormones, thyroid function, and vitamin levels with premature ejaculation: A prospective case-control study

Pazır,

Guler,

Bulut

et al. 2024

Investig Clin Urol

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Purpose To investigate whether serum hormone (testosterone, prolactin, gonadotropins, and thyroid hormones) and vitamin (vitamin B 12 , folic acid, and vitamin D) levels are associated with premature ejaculation (PE). Materials and Methods This prospective case-control study included 126 patients with PE (lifelong PE [LPE] in 94 and acquired PE [APE] in 32) who presented to the urology outpatient clinic between April 2016 and January 2023 and 92 healthy men as a control group. The diagnosis of PE was based on the criteria defined by the International Society for Sexual Medicine. Serum total testosterone (TT), free and bioavailable testosterone, follicle-stimulating hormone, luteinizing hormone, prolactin, thyroid-stimulating hormone, free triiodothyronine, thyroxine (fT 4 ), vitamin B 12 , folic acid, and vitamin D levels were measured. Results Serum TT, fT 4 , and vitamin D levels were significantly higher in patients with PE than in the control group (p=0.022, p=0.002, and p=0.044, respectively). However, the serum vitamin B 12 level was significantly lower in the PE group (p=0.021). In the multivariate logistic regression analysis, only vitamin B 12 was found to be an independent risk factor for PE, with an estimated odds ratio of 0.997 (95% confidence interval 0.994–0.999, p=0.036). Conclusions This study demonstrated that lower vitamin B 12 levels are associated with the presence of PE. Therefore, we believe that it would be beneficial to consider vitamin B 12 levels in the evaluation of patients with PE.

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Serum vitamin D level may be a novel potential risk factor for premature ejaculation: a comparative study

Abstract: The current study showed that vitamin D has significant association with LPE and correlates significantly with IELT and PEDT.

Cited by 9 publications

References 30 publications

Study of the role of microRNAs 16 and 135a in patients with lifelong premature ejaculation receiving fluoxetine daily for 3 months: A prospective case control study

Study of the role of microRNAs 16 and 135a in patients with lifelong premature ejaculation receiving fluoxetine daily for 3 months: A prospective case control study

Premature Ejaculation and Endocrine Disorders: A Literature Review

The association of reproductive hormones, thyroid function, and vitamin levels with premature ejaculation: A prospective case-control study

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