Premature Ejaculation and Endocrine Disorders: A Literature Review

Abstract

Premature ejaculation (PE) is the most common male sexual dysfunction, with 30% of men experiencing PE worldwide. According to the generally accepted classification, there are two types of PE: lifetime PE and acquired PE. Various biological and psychological causes are known to be involved in the etiology of PE. However, due to the incomplete definition and etiopathogenesis of PE, there is no effective treatment. Although clinical and animal studies indicate that hormones play a role in controlling the ejaculation process, the precise endocrine mechanisms are unclear. In addition, little is known about the role of endocrine disorders in PE etiology. However, there is evidence that diabetes mellitus (DM), obesity, metabolic syndrome (MetS), thyroid gland disorders, pituitary gland disorders, and vitamin D deficiency affect the prevalence of PE. Moreover, it has been reported that the prevalence of PE decreases with treatment of these endocrine disorders. In this review, the relationship between PE and DM, MetS, obesity, vitamin D deficiency, and thyroid and pituitary gland disorders is summarized.

Erectile Dysfunction in Relation to Metabolic Disorders and the Concentration of Sex Hormones in Aging Men

“…Testosterone is considered the principal hormone involved in male gonad formation and ejaculation control. However, there are contradictory data regarding the correlation between testosterone levels and PE [7,8].…”

Nomogram for stratifying patients with lifelong premature ejaculation before using the PHQ‐9: An observational study

“…The following limitations of this study should be considered. (1) The IELT used in this study was self-reported, which may lead to an overestimation, 30 and hence have lower accuracy than the stopwatch-measured IELT. (2) Although careful communication was conducted with all patients to explain the questionnaire before they filled them, it could still exist subjectivities associated with questionnaire filling.…”

The network meta‐analysis of “on‐demand” and “daily” use of paroxetine in treating men with premature ejaculation from randomized controlled trials

“…Currently, PE is considered as a neurobiological dysfunction that is correlated with the impairment of neurotransmission at central serotonin and 5‐HT postsynaptic receptors (Coskuner & Ozkan, 2021). Therefore, SSRIs are the main drugs recommended by ISSM for the treatment of PE (Althof et al, 2014b).…”

“…The common AEs related with paroxetine were fatigue, yawning and abnormal sleep (10.96%), gastrointestinal upset (10.80%).F I G U R E 5Forest plots showing the intravaginal ejaculatory latency time of 20 mg paroxetine on-demand versus other treatment. CI, confidence interval; df, degrees of freedom; IV, inverse variance; SD, standard deviation Currently, PE is considered as a neurobiological dysfunction that is correlated with the impairment of neurotransmission at central serotonin and 5-HT postsynaptic receptors(Coskuner & Ozkan, 2021). Therefore, SSRIs are the main drugs recommended by ISSM…”