Serum Vitamin D Is Significantly Inversely Associated with Disease Severity in Caucasian Adults with Obstructive Sleep Apnea Syndrome

Abstract

We observed widespread vitamin D deficiency and insufficiency in a Caucasian, OSAS population. There were significant, independent, inverse relationships between 25(OH)D and AHI as well as nocturnal HR, a known cardiovascular risk factor. Further, 25(OH)D was significantly lower in OSAS cases compared to matched, non-OSAS subjects. We provide evidence that 25(OH)D and OSAS are related, but the role, if any, of replenishment has not been investigated.

Sleep Quality in Non Dialysis Chronic Kidney Disease: Associated Factors and Influence on Prognosis

“…As far as we are aware, this is the first report underlining the association between low vitamin D levels and poor SQ in renal disease. In agreement with this observation, recent data support an inverse relationship between vitamin D levels and OSA severity [21]. Furthermore, vitamin D supplementation has been linked with RLS improvement [22].…”

Vitamin D Improves Selected Metabolic Parameters but Not Neuropsychological or Quality of Life Indices in OSA: A Pilot Study

“…[6][7][8] A recent study suggested that the association between lower 25(OH) D and OSA was largely confounded by larger BMI and neck circumference. 9 In contrast, our group 10 and others [11][12][13][14] have reported a high rate of vitamin D deficiency in OSA, where vitamin D levels (25(OH)D) are lower in severe OSA 10,11,13 and inversely correlate with some of its associated metabolic alterations, including abnormal glucose metabolism 11,12 as well as nocturnal heart rate. 10 Vitamin D receptors are located systemically and recent advances have demonstrated the potential of vitamin D to influence a wide variety of organs.…”

“…9 In contrast, our group 10 and others [11][12][13][14] have reported a high rate of vitamin D deficiency in OSA, where vitamin D levels (25(OH)D) are lower in severe OSA 10,11,13 and inversely correlate with some of its associated metabolic alterations, including abnormal glucose metabolism 11,12 as well as nocturnal heart rate. 10 Vitamin D receptors are located systemically and recent advances have demonstrated the potential of vitamin D to influence a wide variety of organs. There is preliminary evidence that vitamin D supplementation may attenuate some metabolic disturbances through antiinflammatory, antihyperglycemic, and antihyperlipidemic roles, although these potential effects are inconsistent and controversial.…”

“…[6][7][8] We and others have observed widespread vitamin D OSA. [9][10][11][12][13][14] Interestingly, 25(OH)D levels have been shown to be inversely correlated with OSA severity 10,11,13 and with metabolic alterations associated with OSA, including abnormal glucose metabolism 11,12 and nocturnal heart rate.…”

“…10 At each time point, subjects reported to our research facility after an overnight fast, had blood drawn, and consumed 75 g of glucose. Next, a battery of self-report questionnaires was completed in the same order followed by neuropsychological testing and a second blood sample was taken 2 h after glucose ingestion (Figure 1).…”