A meta‐analysis: Does vitamin D play a promising role in sleep disorders?

Yan, Shoumeng; Tian, Zhen-Wei; Zhao, Hantong; Wang, Changcong; Pan, Yingan; Yao, Nan; Guo, Yinpei; Han, Wei; Li, Bo; Cui, Weiwei

doi:10.1002/fsn3.1867

Cited by 9 publications

(8 citation statements)

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“…This systematic review and meta-analysis investigated the effect of VDS on sleep quantity and quality, and sleep disorders. VDD is an emerging risk factor for suboptimal sleep and sleep disorders [ 12 , 15 , 43 ]. Such an association has been observed in several healthy and ill populations including factory workers, older community-dwelling men, hemodialysis patients, and pregnant women [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…They also provided evidence that serum 25(OH)D below 20 ng/mL could significantly heighten the odds of unhealthy sleep [ 15 ]. Similarly, through a meta-analysis of observational studies conducted on 1864 subjects with sleep disorders and 1340 control participants, Yan et al [ 43 ] found that the average serum vitamin D concentration in the group with sleep disorders was 0.75 ng/mL lower than that in the control group [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

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Vitamin D Supplementation and Sleep: A Systematic Review and Meta-Analysis of Intervention Studies

Abboud

2022

Nutrients

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Background: Vitamin D deficiency is associated with sleep disorders and poor sleep quality. Whether vitamin D supplementation (VDS) helps resolve these problems remains unclear. Objective: To systematically review the effect of VDS on sleep quantity, quality, and disorders, and perform a meta-analysis of available data. Methods: The reporting of this review followed the PRISMA statement. VDS human interventions studies that reported on sleep quality, quantity, or disorders were included. Medline, CINAHL, EMBASE, PsycInfo, the Cochrane Library, Clinicaltrials.gov, and the ICTRP were searched, in addition to the references of the included articles and previous relevant reviews, without language or time restrictions. Included studies were critically appraised, findings were narratively synthesized, and a meta-analysis was conducted. Furthermore, the overall certainty of the evidence was assessed. Results: A total of 19 studies were included (13 randomized controlled trials (RCTs), 1 opportunistic addition to an RCT, 4 pre–post studies, and 1 pre–post study analyzed as a case series); 3 RCTs were meta-analyses. The risk of bias was generally low. Pre–post studies showed a significant improvement in sleep quality with VDS. Similarly, the results of the meta-analysis revealed a statistically significant decrease in the Pittsburgh Sleep Quality Index with VDS compared with placebo (mean difference, −2.33 (95% CI, −3.09, −1.57); p < 0.001; I2 = 0%), with a moderate certainty of evidence. The results regarding the effect of VDS on sleep-related impairment, difficulty, and disorders, as well as sleepiness and restless legs syndrome, were not unanimous. Conclusions: VDS is promising in improving sleep quality; however, its effect on sleep quantity and disorders needs to be further investigated.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Vitamin D Supplementation and Sleep: A Systematic Review and Meta-Analysis of Intervention Studies

Abboud

2022

Nutrients

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“…These factors increased in people with vitamin D deficiency. Therefore, they lead to sleep disorders such as OSAS (Obstructive Sleep Apnea Syndrom) (Yan et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

The effect of vitamin D on sleep quality: A systematic review and meta-analysis

2022

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Background: Poor sleep quality is a common problem in the general population that affects the quality of life of individuals. Aim: This systematic review aimed to determine the effect of vitamin D on sleep quality (primary outcome) and side effects (secondary outcome). Methods: A systematic search was performed using Cochrane Library, PubMed, Embase, Web of Sciences, Scopus, Google Scholar, SID, and Magiran databases with no limit at the time of publication. Cochrane collaboration instrument was used to evaluate the quality of the included studies. RevMan software was used for meta-analysis. Mean Difference was calculated due to the same sleep quality measurement tools in all studies. Heterogeneity of studies was assessed using I-squared ([Formula: see text]). Due to high heterogeneity ([Formula: see text] > 75%), Random Effect was used instead of Fixed Effect. Results: Out of a total of 1637 titles and abstracts found, after removing duplicate items (23 items), 1596 items were removed due to irrelevance and lack of inclusion criteria. 18 articles were fully studied due to insufficient abstract information and finally, 5 articles were entered into systematic review and meta-analysis. The results of the meta-analysis showed that the use of vitamin D supplementation significantly improves sleep quality (MD: −1.32; 95%CI: −2.55 to −0.09; P = 0.04). Conclusions: Also, according to the findings of this study, receiving vitamin D supplementation did not cause any side effects. According to the results of this review study, sleep quality in people receiving vitamin D significantly improved compared to the control group.

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“…Significant evidence has indicated the association between various sleep behaviors and vitamin D metabolism ( 12 , 13 ). Several observational meta-analyses ( 14 , 15 ) showed obstructive sleep apnea (OSA) and sleep disorders were associated with lower 25(OH)D concentrations. There is evidence in showing there are vitamin D receptors in the brain involved in the sleep-wake cycle ( 16 ), providing a mechanistic explanation for how vitamin D deficiency can contribute to sleep disturbances.…”

Section: Introductionmentioning

confidence: 99%

Sleep patterns modify the association of 25(OH)D with poor cardiovascular health in pregnant women

Yin

Wang

et al. 2022

Front. Nutr.

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BackgroundThe relationship between vitamin D status and gestational cardiovascular health (CVH) is inconsistent in previous studies. Emerging evidence shows that sleep behaviors are related to vitamin D metabolism. However, no studies evaluate the interaction of vitamin D and sleep behaviors on gestational CVH.ObjectiveWe aimed to estimate the relationship between 25-hydroxyvitamin D [25(OH)D] concentrations and gestational CVH, and whether the relationship was modified by sleep behaviors.MethodsThe data of this study was from a multicenter birth cohort study. A total of 9,209 pregnant women at 16–23 weeks of gestation were included. 25(OH)D concentrations were measured from collected blood. Sleep patterns consisted of major sleep behaviors including duration, chronotype, insomnia, snoring, and excessive daytime sleepiness. Data on poor CVH was based on four “clinical” CVH metrics, including body mass index, blood pressure, total cholesterol, and glucose levels.ResultsThe proportion of women with poor CVH was 25.0%. The relative risk (RR) (95%CI) of poor CVH was 0.67 (0.58–0.76) in women with 25(OH)D ≥ 50 nmol/L after multivariate adjustments. Lower 25(OH)D concentrations were significantly associated with poor CVH. Such association was also evident in subgroups analysis. We found a significant interaction of 25(OH)D (P for interaction = 0.01) with sleep patterns on the risk of poor CVH. A negative dose-response relation was observed between 25(OH)D concentrations and poor CVH risk in healthy or intermediate sleep, not poor sleep. 25(OH)D concentrations were lower and the risk of poor CVH was higher in pregnant women with poor sleep patterns (P < 0.05).ConclusionOur study suggests that sleep patterns modify the association of 25(OH)D concentrations with the CVH among pregnant women.

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A meta‐analysis: Does vitamin D play a promising role in sleep disorders?

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 9 publications

References 55 publications

Vitamin D Supplementation and Sleep: A Systematic Review and Meta-Analysis of Intervention Studies

Vitamin D Supplementation and Sleep: A Systematic Review and Meta-Analysis of Intervention Studies

The effect of vitamin D on sleep quality: A systematic review and meta-analysis

Sleep patterns modify the association of 25(OH)D with poor cardiovascular health in pregnant women

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