Vitamin D Supplementation and Sleep: A Systematic Review and Meta-Analysis of Intervention Studies

Abboud, Myriam

doi:10.3390/nu14051076

Cited by 18 publications

(13 citation statements)

References 53 publications

(219 reference statements)

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“…There were major disparities in the research populations, including genetic, regional, and cultural background, outcomes and assessment techniques, treatment regimes, duration of study periods, and seasonality of testing. As stated in a recent scientific paper, the latter two may have a significant impact on the study's outcome [104].…”

Section: Discussionmentioning

confidence: 94%

The Role of Vitamin D in Basal Ganglia Diseases

Homann¹,

Homann²

2022

J. Integr. Neurosci.

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Objective: Vitamin D (VitD) has been shown to influence several cellular processes in the brain. The extent to which VitD plays a role in the pathomechanism of neuronal loss and dysfunction in basal ganglia diseases (BGDs) is still debated. There is yet to be a comprehensive study that provides an overview of all of the most relevant BGDs. Methods: PubMed, and Google Scholar were systematically searched for observational studies that investigated the association between serum VitD levels and BGDs up to March 2022. Results: We extracted 60 studies, but with a great variety of design and quality. VitD deficiency appears to be common in most BGDs, but only in Parkinson's disease (PD) has a causal association been fully examined. There is some evidence that low VitD serum levels influence symptom severity, most notably in restless legs syndrome (RLS), PD, and tic disorders. The effects of vitamin D supplementation were studied in three BGDs, with results mostly favorable for RLS, ambiguous for tics, and mostly unfavorable for PD. Conclusions: There are still various elements of BGDs with insufficient, ambiguous, or altogether absent evidence, and further high-quality research is required. However, there appears to be sufficient scientific justification already to recommend that practitioners treating BGDs check serum VitD levels and supplement as appropriate.

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Section: Discussionmentioning

confidence: 94%

The Role of Vitamin D in Basal Ganglia Diseases

Homann¹,

Homann²

2022

J. Integr. Neurosci.

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“…Increased body weight is a risk factor for sleep apnoea 66 and perhaps the associated weight gain from infliximab or vitamin D deficiency increases the likelihood of sleep apnea and consequently more likely to have poor sleep. Vitamin D deficiency has been associated with increased risk of sleep disorders 67 and supplementation has been associated with improvement in sleep quality 68 …”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D deficiency has been associated with increased risk of sleep disorders 67 and supplementation has been associated with improvement in sleep quality. 68 Corticosteroids, known to cause sleep disturbances, 69 were associated with worse sleep quality scores and poor sleep. This replicates previous work showing worse sleep quality scores 15,23 in those on corticosteroids.…”

Section: Discussionmentioning

confidence: 99%

Examining the influence of inflammatory bowel disease medications on sleep quality

et al. 2023

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Background and Aim: Inflammatory bowel disease (IBD) can disrupt sleep, leading to poor sleep quality. This may in part be due to the symptoms of IBD and the influence of pro-inflammatory cytokines on sleep. This study aimed to investigate the potential influence of IBD medications on sleep quality. Methods: An online survey of adults with IBD was conducted, which included measures of sleep quality, IBD activity, anxiety, depression, and physical activity. Logistic regression was used to investigate possible associations between IBD medications (corticosteroids, immunomodulators, biologics, aminosalicyate) and outcome of poor sleep. A generalized linear model was built for outcome of sleep quality score. Results: There were 544 participants included in the final analysis, median age of 42, and 61% with Crohn's disease. Increased odds of poor sleep were seen in those taking opioids, medications for anxiety or depression, corticosteroids, vitamin D, methotrexate, and infliximab. A multivariate model was built incorporating demographic and IBD variables with opioids present in the final model and associated with increased odds of poor sleep. This was in addition to medications for sleep, depression, anxiety, IBD activity, and body weight. In a multivariate generalized linear model, opioids and methotrexate were associated with worse sleep quality scores. Conclusions: Opioids were associated with increased odds of poor sleep independent of other factors. This provides further support for avoiding these medications in people with IBD. Infliximab was associated with increased body weight and consequently increased odds of poor sleep.

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“…Low vitamin D status is quite common especially in the winter months in central Europe ( 5 ), and vitamin D deficiency has been associated with impaired sleep ( 6 ). Vitamin D seems to have an important role in sleep regulation ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency promoting non-24 h sleep–wake disorder: a case report

Radlberger

Kunz

2023

Front. Neurol.

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We report a case of an emmetropic woman with excessive daytime sleepiness in alternation with insomnia consistent with the diagnosis criteria of a non-24 h sleep–wake disorder. After being refractory to the usual non-pharmacologic and pharmacologic treatment, we detected a deficiency of vitamin B12, vitamin D3, and folic acid. Substitution of these treatments led to a return of a 24 h sleep–wake rhythm though this remained independent from the external light–dark cycle. The question arises whether the vitamin D deficiency could be regarded as an epiphenomenon or whether there is an up-to-date unknown connection to the inner zeitgeber.

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Vitamin D Supplementation and Sleep: A Systematic Review and Meta-Analysis of Intervention Studies

Cited by 18 publications

References 53 publications

The Role of Vitamin D in Basal Ganglia Diseases

The Role of Vitamin D in Basal Ganglia Diseases

Examining the influence of inflammatory bowel disease medications on sleep quality

Vitamin D deficiency promoting non-24 h sleep–wake disorder: a case report

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