Vitamin D Improves Selected Metabolic Parameters but Not Neuropsychological or Quality of Life Indices in OSA: A Pilot Study

Kerley, Conor P; Hutchinson, Karen; Bramham, Jessica; McGowan, Aisling; Faul, John L.; Cormican, Liam

doi:10.5664/jcsm.6378

Cited by 24 publications

(31 citation statements)

References 35 publications

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“…Previous studies have primarily assessed vitamin D levels in patients with OSA (Archontogeorgis et al ., ; Barcelo et al ., ; Erden et al ., ; Kerley et al ., , ; Mete et al ., ; Salepci et al ., ; Toujani et al ., ), whereas markers of bone turnover have not been studied extensively in this patient group (Terzi and Yilmaz, ). Barcelo et al .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Kerley et al . () showed in a group of patients with OSA that supplementation with vitamin D improved several metabolic variables, such as decreases in both low‐density lipoprotein and lipoprotein‐associated phospholipase A2, as well as trends toward decreased fasting glucose and increased high‐density lipoprotein. However, as we only observed a modification of 25(OHD) and bone turnover markers in certain subsamples of patients and with increased CPAP treatment time frames, this might indicate that OSA impacts energy metabolism only in certain patients.…”

Section: Discussionmentioning

confidence: 99%

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Changes of vitamin D levels and bone turnover markers after CPAP therapy: a randomized sham‐controlled trial

Theorell‐Haglöw

Hoyos

Phillips

et al. 2017

Journal of Sleep Research

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The aim was to investigate whether continuous positive airway pressure treatment could modulate serum vitamin D (25-hydroxyvitamin D) and bone turnover markers (collagen-type 1 cross-linked C-telopeptide, osteocalcin and N-terminal propeptide of type 1 collagen) in secondary analysis from a randomized controlled trial. Sixty-five continuous positive airway pressure-naïve male patients with obstructive sleep apnea (age = 49 ± 12 years, apnea-hypopnea index = 39.9 ± 17.7 events h , body mass index = 31.3 ± 5.2 kg m ) were randomized to receive either real (n = 34) or sham (n = 31) continuous positive airway pressure for 12 weeks. At 12 weeks, all participants received real continuous positive airway pressure for an additional 12 weeks. After 12 weeks of continuous positive airway pressure (real versus sham), there were no between-group differences for any of the main outcomes [Δ25-hydroxyvitamin D: -0.80 ± 5.28 ng mL (mean ± SE) versus 3.08 ± 3.66 ng mL , P = 0.42; Δcollagen-type 1 cross-linked C-telopeptide: 0.011 ± 0.014 ng mL versus -0.004 ± 0.009 ng mL , P = 0.48; Δosteocalcin: 1.13 ± 1.12 ng mL versus 0.46 ± 0.75 ng mL , P = 0.80; ΔN-terminal propeptide of type 1 collagen: 2.07 ± 3.05 μg L versus -1.05 ± 2.13 μg L , P = 0.48]. There were no further differences in subgroup analyses (continuous positive airway pressure-compliant patients, patients with severe obstructive sleep apnea or sleepy patients). However, after 24 weeks irrespective of initial randomization, vitamin D increased in patients with severe obstructive sleep apnea (9.56 ± 5.51 ng mL , P = 0.045) and in sleepy patients (14.0 ± 4.69 ng mL , P = 0.007). Also, there was a significant increase in osteocalcin at 24 weeks (3.27 ± 1.06 ng mL , P = 0.01) in compliant patients. We conclude that 12 weeks of continuous positive airway pressure did not modulate vitamin D or modulate any of the bone turnover markers compared with sham. However, it is plausible that continuous positive airway pressure may have late beneficial effects on vitamin D levels and bone turnover markers in selected groups of patients with obstructive sleep apnea.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Changes of vitamin D levels and bone turnover markers after CPAP therapy: a randomized sham‐controlled trial

Theorell‐Haglöw

Hoyos

Phillips

et al. 2017

Journal of Sleep Research

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“…In addition, information on other sleeprelated disturbances or disorders, including sleep apnoea, were not collected in our study. Several studies have reported that sleep apnoea was associated with lower serum 25OHD levels [79][80][81][82][83][84][85][86][87]. Furthermore, it remains possible that the associations between sleep and vitamin D status may be due to associations with poor health [88], including unmeasured confounding variables such as depression [89] and musculoskeletal pain [39] or inflammation [90]; these unmeasured confounding variables may differ by sex especially in Chinese populations.…”

Section: Plos Onementioning

confidence: 99%

Sleep duration is associated with vitamin D deficiency in older women living in Macao, China: A pilot cross-sectional study

Liang²,

et al. 2020

PLoS ONE

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Chinese women are known to have both a high prevalence of metabolic syndrome (MetS) and vitamin D deficiency (serum 25-hydroxyvitamin D (25OHD) <50 nmol/l). Associations between sleep duration and circulating 25OHD have recently been reported but, to our knowledge, these associations have not been studied in older Chinese populations. We thus investigated whether sleep duration was associated with vitamin D status in a population from Macao, China, and whether sleep duration modified the association between MetS and vitamin D deficiency. In 207 older (>55 years) Macanese, anthropometry, blood samples and validated questionnaires, including sleep duration and cardiovascular risk factors, were simultaneously collected. On multivariable categorical analyses, those women, not men, who had short sleep duration (�6 hours (h)) were at a 2-fold risk for vitamin D deficiency (both <50 nmol/L and <37 nmol/L; OR = 1.94, 95%CI 1.29-2.92; OR = 2.05, 95%CI 1.06-3.98, respectively) and those who had longer sleep duration (>8 h) were 3-fold more likely to have vitamin D deficiency (OR = 3.07, 95%CI 1.47-6.39; OR = 2.75, 95%CI 1.08-7.00, respectively) compared to those with normal sleep duration (6-8 h). Both women and men with MetS were 2-fold more likely to have vitamin D deficiency (women: OR = 2.04, 95%CI 1.31-3.17; OR = 2.15, 95%CI 1.11-4.17, respectively; men: OR = 2.01, 95%CI 1.23-3.28; OR = 2.04, 95%CI 1.00-4.29, respectively). Moreover, women with both short sleep duration and MetS had an increased risk of vitamin D deficiency (OR = 3.26, 95%CI 1.10-9.64). These associations were not found in those with longer sleep. Men with longer sleep and MetS had a 5-fold risk of vitamin D deficiency (OR = 5.22; 95%CI 2.70-10.12). This association was non-significant for men with shorter sleep. We conclude that both short and long sleep duration were associated with vitamin D deficiency in older Chinese women. Further research is needed in larger cohorts or with intervention studies to further examine the associations between reduced sleep, metabolic syndrome and vitamin D deficiency.

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“…The increase in serum 25OHD levels and decrease in both sleepiness and AHI were mainly observed in the obese patients compared to non-obese OSA men treated with CPAP. A pilot study assessing Caucasian OSA individuals submitted to cholecalciferol supplementation (4000 IU/ day) during 15 weeks (Kerley et al 2017) showed an increase in 25OHD serum levels in the supplemented group vs placebo (100.8 ± 39.9 nmol/L × 43.0 ± 21.4 nmol/L, respectively), and a decrease in metabolic parameters such as low-density lipoprotein (LDL) and lipoproteinassociated phospholipase A2 (Lp-PLA2). Some subjects from both groups used CPAP, but the data were not controlled, hampering the interpretation about the benefits of the supplementation since there is current evidence that CPAP use can increase 25OHD levels (Liguori et al 2015).…”

Section: :1mentioning

confidence: 99%

The interfaces between vitamin D, sleep and pain

Oliveira

Hirotsu

Tufik

et al. 2017

Journal of Endocrinology

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The role of vitamin D in osteomineral metabolism is well known. Several studies have suggested its action on different biological mechanisms, such as nociceptive sensitivity and sleep-wake cycle modulation. Sleep is an important biological process regulated by different regions of the central nervous system, mainly the hypothalamus, in combination with several neurotransmitters. Pain, which can be classified as nociceptive, neuropathic and psychological, is regulated by both the central and peripheral nervous systems. In the peripheral nervous system, the immune system participates in the inflammatory process that contributes to hyperalgesia. Sleep deprivation is an important condition related to hyperalgesia, and recently it has also been associated with vitamin

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Vitamin D Improves Selected Metabolic Parameters but Not Neuropsychological or Quality of Life Indices in OSA: A Pilot Study

Cited by 24 publications

References 35 publications

Changes of vitamin D levels and bone turnover markers after CPAP therapy: a randomized sham‐controlled trial

Changes of vitamin D levels and bone turnover markers after CPAP therapy: a randomized sham‐controlled trial

Sleep duration is associated with vitamin D deficiency in older women living in Macao, China: A pilot cross-sectional study

The interfaces between vitamin D, sleep and pain

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