Serum Vitamin B12and Folic Acid Activity in Lactovegetarian and Nonvegetarian Healthy Adult Indians

Mehta, Bipin M.; Rege, D. V.; Satoskar, R. S.

doi:10.1093/ajcn/15.2.77

Cited by 42 publications

(27 citation statements)

References 21 publications

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“…This is consistent with earlier studies that have shown that urinary vitamin B 12 increased by only 1.5-2 times when 1 mg vitamin B 12 , which is 300 times higher than usual intake, was administered orally, and by only 2-3 times when 0.45 mg was injected intramuscularly (Pitney and Beard, 1954;Mehta and Regr, 1964). Foods that included vitamin B 12 were very limited; therefore, its intake showed very high inter-and intraindividual variation in our study.…”

Section: Discussionsupporting

confidence: 93%

Twenty-four-hour urinary water-soluble vitamin levels correlate with their intakes in free-living Japanese university students

et al. 2010

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Background/Objectives: We examined the association between 24-h urinary excretion of water-soluble vitamin levels and their intakes in free-living Japanese university students. The design used was cross-sectional study. Subjects/Methods: A total of 216 healthy, free-living male and female Japanese university students aged 18-27 years voluntarily participated in this study, of which 156 students were eligible for this assessment. All foods consumed for 4 consecutive days were recorded accurately by a weighed food record method. A 24-h urine sample was collected on the fourth day, and the urinary levels of water-soluble vitamins were measured. Mean estimated water-soluble vitamin intakes calculated from urinary levels and recovery rates showed 91-101% of their 3-day mean intakes, except for vitamin B 12 (61%). Conclusions: These results showed that urinary water-soluble vitamin levels, except for vitamin B 12 , reflect their recent intakes in free-living Japanese university students, and could be used as a potential biomarker to estimate mean vitamin intake.

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Section: Discussionsupporting

confidence: 93%

Twenty-four-hour urinary water-soluble vitamin levels correlate with their intakes in free-living Japanese university students

et al. 2010

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“…However, the incidence of megaloblastic anaemia or neurolog ical disease due to Bl2 deficiency in India does not appear to be high [5]. In fact, the lactovegetarian volunteer students with low serum vitamin B12 levels showed no clinical evidence of vitamin B12 deficiency [15,18]. The present study was undertaken to investigate further the signifi…”

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confidence: 99%

“…Purely on the basis of serum vitamin B l2 levels, large part of the Indian population could be considered deficient in this vitamin [2,7,15,18]. However, the incidence of megaloblastic anaemia or neurolog ical disease due to Bl2 deficiency in India does not appear to be high [5].…”

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confidence: 99%

Vitamin B<sub>12</sub> and Vegetarianism in India

et al. 1975

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Apparently healthy Indian lactovegetarians have significantly lower serum levels and urinary excretion of vitamin B₁₂ as compared to non-vegetarians. The low levels of serum vitamin B₁₂ in lactovegetarians are not due to defective absorption but to low dietary intake of this vitamin. Inspite of considerably low serum vitamin B₁₂ values, the lactovegetarians have no apparent signs or symptoms of vitamin B₁₂ deficiency and their response to injected cyanocobalamin mixed with tracer radioactive B₁₂, as judged by urinary excretion pattern and liver uptake, was similar to that observed in non-vegetarians.

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“…In a study by Mehta et al in healthy Indian University students, serum vitamin B 12 levels were below 200 pg/ml in 80% of the lacto vegetarians. 15 Herrmann et al reported 77% of the lactovegetarians had low serum vitamin B 12 level. 16 Alexander D et al from New-Zealand found that 35% of the long-term vegetarians had serum vitamin B 12 concentrations below the reference range.…”

Section: Discussionmentioning

confidence: 98%

Study of vitamin B12 status and the consequential clinico-hematological profile in healthy vegetarian population in Nepal

Paudel

Agrawal²,

Timilsena

et al. 2017

J Chitwan Med Coll

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Background: A strict vegetarian diet has been associated with an increased risk of vitamin B12 deficiency. Clinical manifestations of cobalamin deficiency are hematologic and neurological symptoms. The purpose of this study was to determine the prevalence of vitamin B12 deficiency in healthy vegetarian population and to study the clinical and hematological profile of vitamin B12 deficient subjects. Methods: A community based cross-sectional observational study was conducted through preplanned camps in Kathmandu Nepal. 166 vegetarian people were investigated for serum vitamin B12 level and their hematological profile was done. They were examined for neurological manifestation of vitamin B12 deficiency. Results: The mean serum vitamin B12 level of the vegetarian in this study was 271.34 ±241.74 pg/ml (mean ± SD)., 53.6 % had serum vitamin B12 deficiency. 56.5 % of male and 47.1 % of female had vitamin B12 deficiency. The risk of vitamin B12 deficiency is more in males than females with odds ratio 1.201 (CI=95%) which is not statistically significant with p-value 0.312. There was no significant difference in vitamin B12 level in different age group.The study population had mean hemoglobin of 13.12 ± 1.72 gm/dl. Anemia was present in 34.9 % of study population. 33.9 % of male and 37.3 % of female had anemia. There was no significant difference in anemia in male and female vegetarian (p-value 0.72). 40% of patient who had vitamin B12 deficiency had anemia.A significant low hemoglobin level and higher MCV were found as level of serum vitamin B12 decreased. Only one patient had macrocytic anemia.There were few symptoms but not specific to vitamin B12 deficiency. Conclusion: The result of present study show that prevalence of vitamin B12 deficiency among healthy vegetarian was 53.6% with higher prevalence in male and elder age group.Prevalence of anemia was 34.9% in this study with elderly group and females being more affected.There was significant correlation between vitamin B12 and hemoglobin level and significant negative correlation with MCV. Although, not significant, leucocytes count, lymphocyte count and platelets were low in vitamin B12 deficient population.Few clinical features were present in vitamin B12 deficient subjects but neurological features specific to vitamin B12 deficiency were not seen.

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Serum Vitamin B12and Folic Acid Activity in Lactovegetarian and Nonvegetarian Healthy Adult Indians

Cited by 42 publications

References 21 publications

Twenty-four-hour urinary water-soluble vitamin levels correlate with their intakes in free-living Japanese university students

Twenty-four-hour urinary water-soluble vitamin levels correlate with their intakes in free-living Japanese university students

Vitamin B<sub>12</sub> and Vegetarianism in India

Study of vitamin B12 status and the consequential clinico-hematological profile in healthy vegetarian population in Nepal

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