Abstract:Visfatin may induce the expression of pro-angiogenic factors, such as VEGF and MMP-9, in women with PCOS, inplying gradually development of endothelial dysfunction. Further studies are required to clarify these findings.
“…iNAMPT over-expression as well as increased circulating levels of eNAMPT were documented in metabolic/inflammatory conditions including obesity, type 2 diabetes, metabolic syndromes, atherogenic inflammatory diseases, therefore supporting a role for eNAMPT as a potential biomarker of cardio-cerebro-vascular disorders (157)(158)(159)(160). Enhanced eNAMPT levels are also described in kidney transplantation recipients (161), polycystic ovary syndrome (162), preeclampsia (163), and acute coronary syndrome (158,164). Increased eNAMPT levels were additionally reported in non-metabolic chronic inflammatory diseases [i.e., osteoarthritis (103) and acute lung injury (ALI) (165,166)], characterized by systemic inflammation.…”
Section: Nampt and Naprt As Biomarkers Of Chronic And Acute Inflammatmentioning
Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT) are two intracellular enzymes that catalyze the first step in the biosynthesis of NAD from nicotinamide and nicotinic acid, respectively. By fine tuning intracellular NAD levels, they are involved in the regulation/reprogramming of cellular metabolism and in the control of the activity of NAD-dependent enzymes, including sirtuins, PARPs, and NADases. However, during evolution they both acquired novel functions as extracellular endogenous mediators of inflammation. It is well-known that cellular stress and/or damage induce release in the extracellular milieu of endogenous molecules, called alarmins or damage-associated molecular patterns (DAMPs), which modulate immune functions through binding pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), and activate inflammatory responses. Increasing evidence suggests that extracellular (e)NAMPT and eNAPRT are novel soluble factors with cytokine/adipokine/DAMP-like actions. Elevated eNAMPT were reported in several metabolic and inflammatory disorders, including obesity, diabetes, and cancer, while eNAPRT is emerging as a biomarker of sepsis and septic shock. This review will discuss available data concerning the dual role of this unique family of enzymes.
“…iNAMPT over-expression as well as increased circulating levels of eNAMPT were documented in metabolic/inflammatory conditions including obesity, type 2 diabetes, metabolic syndromes, atherogenic inflammatory diseases, therefore supporting a role for eNAMPT as a potential biomarker of cardio-cerebro-vascular disorders (157)(158)(159)(160). Enhanced eNAMPT levels are also described in kidney transplantation recipients (161), polycystic ovary syndrome (162), preeclampsia (163), and acute coronary syndrome (158,164). Increased eNAMPT levels were additionally reported in non-metabolic chronic inflammatory diseases [i.e., osteoarthritis (103) and acute lung injury (ALI) (165,166)], characterized by systemic inflammation.…”
Section: Nampt and Naprt As Biomarkers Of Chronic And Acute Inflammatmentioning
Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT) are two intracellular enzymes that catalyze the first step in the biosynthesis of NAD from nicotinamide and nicotinic acid, respectively. By fine tuning intracellular NAD levels, they are involved in the regulation/reprogramming of cellular metabolism and in the control of the activity of NAD-dependent enzymes, including sirtuins, PARPs, and NADases. However, during evolution they both acquired novel functions as extracellular endogenous mediators of inflammation. It is well-known that cellular stress and/or damage induce release in the extracellular milieu of endogenous molecules, called alarmins or damage-associated molecular patterns (DAMPs), which modulate immune functions through binding pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), and activate inflammatory responses. Increasing evidence suggests that extracellular (e)NAMPT and eNAPRT are novel soluble factors with cytokine/adipokine/DAMP-like actions. Elevated eNAMPT were reported in several metabolic and inflammatory disorders, including obesity, diabetes, and cancer, while eNAPRT is emerging as a biomarker of sepsis and septic shock. This review will discuss available data concerning the dual role of this unique family of enzymes.
“…They showed that the serum level of MMP-9 was signi cantly higher in women with PCOS compared to the control group (42). The study of Dambala et al in 2017 also showed the same result (43). In the study of Javed et al (2913), the level of MMP-8 was higher in the saliva and serum of patients with PCOS and periodontal disease compared to the control group (comprised of women who were systemically healthy and had healthy gums) (16).…”
Background: There is emerging evidence to support the link between polycystic ovarian syndrome (PCOS) and periodontal disease, but the mechanisms associated with these two diseases have not been clearly elucidated but relate to different aspects of inflammation. This study aimed to determine the gingival inflammation indexes and matrix metalloproteinase-9 (MMP-9) in patients with polycystic ovarian syndrome compared to control group.Methods: This is a case-control study in which 87 women referred to the Babol Clinic Private Hospital were divided into three groups: 26 women with PCOS diagnosed on the basis of Rotterdam criteria with gingivitis, 26 women with PCOS without gingivitis and 26 healthy women who were matched for age and body mass index. After recording the underlying variables, fasting saliva samples were taken from all participants in the morning before any periodontal intervention. The samples, which were transferred to Babol Molecular Cell Research Center under cold-chain conditions to measure the serum levels of MMP-9 using ELISA kits. Periodontal status was evaluated for Gingival index (GI), bleeding on probing (BOP), plaque index (PI). Analysis of variance was used to compare the results for the normal quantitative variables and Chi-square test was used to compare the qualitative variables. Significance level was considered less than 0.05.Results: The highest mean periodontal disease indexes (GI, BOP, PI) were observed in women with PCOS with gingivitis and then in women with PCOS without gingivitis and then in healthy women in control group (p <0.05). The mean salivary MMP-9 levels were significantly higher in PCOS women (388/37 ± 75.05) compared to the control group (166/25 ± 35/43). Even in PCOS patients with healthy gingiva (233.00± 47.76) had higher levels of salivary MMP-9 than the control group and this difference was significant (p <0.05)Conclusions: There is a positive association between periodontal disease and PCOS and that salivary MMP-9 levels are higher in PCOS women with and without gingivitis than healthy women. However, it is recommended that multicenter study with larger sample sizes are to be conducted to establish a clearer association.
“…VEGF protein is known to be closely related to the pathogenesis of PCOS. Serum VEGF levels are significantly elevated in PCOS patients [16][17][18]. High levels of serum VEGF result in a higher number of active granuloas lutein cells (GLCs), increase secretion of GLCs, and up-regulate VEGF gene expression [40].…”
Section: Discussionmentioning
confidence: 99%
“…Vascular endothelial growth factor (VEGF), a homodimeric glycoprotein hormone first purified by Ferrara et al from the bovine pituitary follicular stellate cells in vitro, is the most active angiogenic factor ever known, which can maintain the differentiation state of vascular endothelial cells and improve microvascular permeability, and play a powerful regulatory role in the occurrence and development of various diseases [14,15]. It is closely related to the pathogenesis of PCOS, and studies have reported a significant rise in serum level of VEGF in the PCOS patients [16][17][18]. Additionally, the overexpression of VEGF gene in the polycystic ovarian stroma also reveals the critical role of this gene in the pathophysiology of PCOS [19].…”
Background: Polycystic ovarian syndrome (PCOS) is a multi-gene hereditary disorder caused by the interaction of certain gene variation with environmental factors. Previous studies have shown that vascular endothelial growth factor (VEGF) gene polymorphisms are associated with the risk of polycystic ovarian syndrome. However, the results of these studies remain controversial. We performed the present meta-analysis aiming to further investigate the potential relationship between VEGF polymorphisms and susceptibility to PCOS. Methods: The following databases were systematically searched: PubMed, EMBASE, Web of Science (WOS), China National Knowledge Infrastructure (CNKI), and Wanfang Databases. The correlation between VEGF polymorphisms and PCOS risk was assessed by calculating pooled odds ratios (ORs) and their 95% confidence intervals (95% CIs). Subgroup analyses stratified by ethnicity and source of control were also conducted. Besides, trial sequential analysis (TSA) was done to verify the reliability of the pooled results. Results: 10 relevant case-control studies were incorporated in this meta-analysis, involving 1347 PCOS cases and 1378 controls. The VEGF rs2010963 polymorphism was associated with decreased PCOS risk in the whole population and the Asian populations. The VEGF rs3025039 polymorphism was associated with decreased PCOS susceptibility and the Asian populations, but increased risk of PCOS was observed among the Caucasian populations. In addition, the results of trial sequential analysis (TSA) showed the negative correlation between rs2010963 and PCOS risk, obtained by our meta-analysis, was stable and reliable. Conclusion: Overall, different VEGF gene polymorphisms may exert different effects on PCOS susceptibility. The VEGF rs2010963 polymorphism decreases PCOS susceptibility in both the whole population and the Asian populations, and VEGF rs3025039 polymorphism causes lower PCOS susceptibility in the whole population and the Asian populations but higher in the Caucasian populations.
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