Serum Uric Acid Level and Cardiovascular Risks in Hemodialysis Patients: An Algerian Cohort Study

Lower serum uric acid level predicts mortality in dialysis patients

“…An advanced age and menopausal status, [35,36] impaired renal uric acid excretion state, and sex hormonal dysfunction in the uremic status [37] may affect the SUA metabolism, although further studies are warranted to clarify this smaller sex difference of the SUA level and its mechanism. The relationship between the SUA level and mortality in those with ESRD has been explored in 5 HD cohorts [16,[19][20][21]38] and 3 PD cohorts, [25,26,39] and the results were diverse. Several studies showed that a low SUA level may be harmful against mortality, [16,[19][20][21]26] whereas others insisted that hyperuricemia increased mortality.…”

“…Several studies showed that a low SUA level may be harmful against mortality, [16,[19][20][21]26] whereas others insisted that hyperuricemia increased mortality. [25,38] One study even reported that the prognostic value of SUA on mortality was weak, and it may be confounded by traditional cardiovascular risk factors or uremia-related factors. [39] This heterogeneity may be derived by many confounders that affect SUA levels in patients on dialysis.…”

The effect of small dose of topiroxostat on serum uric acid in patients receiving hemodialysis

“…There have been several reports on the influence of hyperuricemia on cardiovascular events or all‐cause mortality in HD patients. Many of them have demonstrated so‐called J‐curve phenomena where hypouricemia as well as hyperuricemia is the risk for cardiovascular events . The following mechanisms have been proposed for the increase in the risk by hypouricemia: 1)Hypouricemic patients are in poor nutritional condition because uric acid is an indicator of nutritional status; and 2)Hypouricemic patients do not have the benefit of vascular protection mediated by antioxidant action of uric acid …”

“…Many of them have demonstrated socalled J-curve phenomena where hypouricemia as well as hyperuricemia is the risk for cardiovascular events. [9][10][11][12] The following mechanisms have been proposed for the increase in the risk by hypouricemia:…”

Evaluation of Relationship Between Uric Acid and CRP, RDW, and MPV as Cardiovascular Risk Factors in Patients with Hypertension

“…Kraus et al (18) stated that hsCRP was not a distinct criterion for the determination of cardiovascular disease risk because of ethnicity, gender, obesity, and comorbidities. Gouri et al (19) found a relationship between high uric acid level and diabetes and HT in 45 hemodialysis patients and they detected cardiovascular diseases to be associated with low serum uric acid level. Ofori et al (20) reported a significant relationship between serum uric acid levels and target organ damage in hypertensive patients.…”