Evaluation of Relationship Between Uric Acid and CRP, RDW, and MPV as Cardiovascular Risk Factors in Patients with Hypertension

Abstract

Objective: Many factors that are associated with both clinical outcomes and pathogenesis of disease in cases of essential hypertension have been reported. One of these is uric acid. In this study, we aimed to investigate the relationship between serum and spot urine uric acid levels and red blood cell distribution width (RDW), mean platelet volume (MPV), and C-reactive protein (CRP) levels in patients with essential hypertension. Methods:Sixty-two patients with essential hypertension were enrolled in the study between January 01, 2013 and December 31, 2013. The presence of cardiovascular disease was assessed by echocardiography, coronary angiography, and stress test. The patients were divided into two groups according to the absence (group 1) or presence (group 2) of cardiovascular complications. Data were collected for serum and spot urine uric acid levels, serum CRP levels, MPV, and RDW and were compared between the two groups.Results: Cardiovascular complications were determined in 23 patients (37.1%). In groups 1 and 2, the CRP level was 4.89 and 3.64, RDW was 13.8 and 13.5, serum uric acid level was 5.57±1.23 and 5.33±0.8, spot urine uric acid level was 65.13±29.11 and 61.94±18.13, and MPV was 7.7 and 7.2, respectively. A significant difference was not found between the two groups in terms of serum and spot urine uric acid levels, serum CRP levels, MPV, and RDW (p>0.05). In group 2, there was a significant negative correlation between the glomerular filtration rate and RDW and between RDW and MPV and positive correlation between CRP levels and RDW (p<0.01, p <0.05, and p<0.05, respectively).Conclusions: Serum and spot urine uric acid levels, serum CRP levels, MPV, and RDW cannot predict the development of cardiovascular disease in patients with essential hypertension.

Evre 3-5 Kronik Böbrek Hastalarında Serum Ürik Asit Seviyesi ve Kardiyovasküler Hastalık Gelişim Riski

“…Li et al (24) and Dong et al (25) reported in their study that hemodialysis patients with low uric acid levels were associated with high risk for cardiovascular mortality and all-cause mortality. Aker Karagöz et al (26) reported that there was no relationship between uric acid level and the development of CVD in hypertensive patients. In another study conducted by Shao et al (27), there was no significant relationship between uric acid level and coronary heart disease in type 2 diabetes patients.…”

Koroner arter kalsiyum skoru kırmızı kan hücresi dağılım genişliği ve ortalama trombosit hacmi ile ilişkilidir

“…Koronerlerde herhangi bir derecede lüminal darlık olanlar KAH grubunda yer alırken, normal koronerleri olanlar ise normal koroner arter (NKA) grubunda sınıflandı. Hastaların klinik, demografik, antropometrik özellikleri, risk faktörleri, kullanmakta oldukları ilaçları, sol ventrikül ejeksiyon fraksiyonları, KAKS'ı da içeren KBTA sonuçları ve eş zamanlı alınan kan örneklerinden çalışılan RDW ve MPV değerlerini de (24,25). Bu parametrelerin hastaların komorbid durumlarından, kullandıkları statin gibi ilaçlardan, beslenme dengesinden, serum vitamin B12, folik asit ve ferritin, demir seviyesini de içeren birçok faktörden de etkilenebileceği düşünülürse bu konuyla ilgili geniş kapsamlı ileri prospektif çalışmalara ihtiyaç duyulmaktadır (21,26,27…”