Lower serum uric acid level predicts mortality in dialysis patients

Bae, Eunjin; Cho, Hyun-Jeong; Shin, Nara; Kim, Sun Moon; Yang, Seung Hee; Kim, Yong Lim; Kang, Shin Wook; Yang, Chul Woo; Kim, Nam Ho; Kim, Yon Su; Lee, Hajeong

doi:10.1097/md.0000000000003701

Cited by 56 publications

(75 citation statements)

References 51 publications

(80 reference statements)

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“…The adjusted HR at uric acid level ≤ 0.488 mmol/L compared with > 0.488 mmol/L was 1.24 (1.03-1.49) for all-cause mortality and 1.54 (1.15-2.07) for CVD mortality. Similar results were found by Bae et al [136]. The authors proposed that elevated uric acid levels among HD patients may be a surrogate marker for better nutritional status, as these patients also had higher serum phosphate and BMI [135].…”

Section: Latif Et Al Reviewed Dopps Data and Found That Higher Uric supporting

confidence: 78%

Cardiovascular Disease in Dialysis Patients

Jegatheesan¹,

Yang²,

Krishnasamy³

et al. 2018

Aspects in Dialysis

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Cardiovascular disease (CVD) is highly prevalent in the dialysis population, affecting up to 60% of cohorts. Cardiovascular mortality rates are reported to be ~14 per 100 patient-years, which are 10-to 20-fold greater than those of age-and gender-matched controls. CVD is the primary cause of death in up to 40% of dialysis patients in Australia, New Zealand and the United States. Dialysis patients endure a greater burden of both traditional risk factors for CVD and risk factors related to loss of kidney function that may account for the higher CVD morbidity and mortality. Many cardiology guidelines include chronic kidney disease (CKD) and end-stage kidney disease (ESKD) as coronary heart disease (CHD) risk equivalents. It is therefore important for clinicians to both recognise and optimise the cardiovascular health of patients receiving maintenance dialysis. This chapter will focus on risk factor modification, screening and prevention of CVD in dialysis patients.

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Section: Latif Et Al Reviewed Dopps Data and Found That Higher Uric supporting

confidence: 78%

Cardiovascular Disease in Dialysis Patients

Jegatheesan¹,

Yang²,

Krishnasamy³

et al. 2018

Aspects in Dialysis

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show abstract

“…Nutritional parameters are closely associated with each other, and high uric acid concentrations have been linked to protein intake or high nPCR, greater BMI, and higher serum concentrations of albumin, creatinine and phosphorus [18][19][20][21][22][23]. The major source of uric acid is purine-rich foods such as meats, seafood and purine-rich vegetables, all of which also include high protein.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, protein-rich diets tend to contain large quantities of purines [25], and higher uric acid concentrations may represent better nutritional status in the ESRD population [18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Serum uric acid, protein intake and mortality in hemodialysis patients

Park

Obi

Streja

et al. 2017

Nephrol. Dial. Transplant.

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“…A cohort study in Japan demonstrated that low uric acid level (<4.6 mg/dl in men and <3.3 mg/dl in women) can increase CVD mortality . Recently, several studies have shown that a low uric acid level was significantly associated with increased all‐cause mortality in patients undergoing dialysis . The uric acid has an antioxidant effect , and it has been demonstrated that hypouricemia can injure the endothelium and induce oxidative stress–related disease such as hypertension, diabetes mellitus, and kidney disease .…”

mentioning

confidence: 99%