Serum TSH levels are associated with cardiovascular risk factors in overweight and obese adolescents

Souza, Luciana Lopes de; Guedes, Erika Paniago; Teixeira, Patricia Fátima dos Santos; Moreira, Rodrigo O.; Godoy-Matos, Amélio F.

doi:10.1016/j.jped.2016.01.011

Cited by 11 publications

(3 citation statements)

References 30 publications

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“…Similar observations were made by German researchers, who examined 1333 people with normal TSH concentrations and demonstrated an increased risk of developing metabolic syndrome in people with TSH concentrations in the upper half of the reference range, compared to patients with TSH concentrations < 2.50 mIU/L, which was indicated by a higher waist-to-hip ratio (WHR) and higher triglyceride concentration [21]. Similar conclusions were also drawn by Souza et al, who demonstrated in a group of 199 obese or overweight teenagers that TSH concentration was positively correlated with the HOMA insulin resistance index, total cholesterol concentration, and triglyceride concentration [22].…”

Section: Original Papersupporting

confidence: 61%

The association of thyroid-stimulating hormone (TSH) and free thyroxine (fT4) concentration levels with carbohydrate and lipid metabolism in obese and overweight teenagers.

Korzeniowska

Brzeziński

Szarejko³

et al. 2019

Endokrynologia Polska

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Introduction: Obesity has increased rapidly among children and adolescents during the last 30 years. Paediatric patients with a BMI above the 85 th centile are more often diagnosed with increased TSH levels than are children with proper body weight. Material and methods: The data of 961 overweight and obese children, aged 13 years, recruited in four cities in Poland as part of PoZdro!, a two-year prophylactic program, were analysed to observe the relationship between serum TSH and fT4 concentration and carbohydrate and lipid metabolism parameters, as well as anthropometric parameters. Results: TSH concentration in the study group was positively correlated, whereas fT4 concentration was negatively correlated with WHR and WHtR values, fasting serum glucose concentrations and one-hour glucose concentration, fasting serum insulin concentrations, one-hour and two-hour insulin concentration, ALT serum activity, as well as total cholesterol, LDL cholesterol, and triglyceride serum concentrations. An increased risk of metabolic syndrome was diagnosed previously in patients with TSH concentrations > 2.5 mUI/L. Conclusions: TSH concentration in the upper half of the current reference range (> 2.50 mIU/L) is associated with an increased risk of lipid and carbohydrate metabolism disorders and therefore increased chances of developing metabolic syndrome. It seems advisable to regularly monitor thyroid function in overweight and obese paediatric patients.

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Section: Original Papersupporting

confidence: 61%

The association of thyroid-stimulating hormone (TSH) and free thyroxine (fT4) concentration levels with carbohydrate and lipid metabolism in obese and overweight teenagers.

Korzeniowska

Brzeziński

Szarejko³

et al. 2019

Endokrynologia Polska

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“…We found that TSH level was independently associated with HOMA-IR levels. In a retrospective study that the patients were subdivided into two groups according to TSH level based on 2.5 µIU/mL, Individuals with TSH Levels >2.5 had higher HOMA-IR and lower HDL levels 16 . Similarly, Nader at al 17 .…”

Section: Discussionmentioning

confidence: 99%

The prevalence of subclinical hypothyroidism in obese children and adolescents and its effects on metabolic parameters

Çelik

2019

Cumhuriyet Medical Journal

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To compare cardiovascular risk factors in obese patients with or without Subclinical Hypothyroidism (SH), also to estimate the prevalence of SH in obese children and adolescents. Method: A total of 226 obese children and adolescents aged 6-18 years were included in the study. Two groups were created as euthyroid group (n=195) and SH group (n=31). After an 8-12 hour overnight fasting, serum blood glucose, insulin, HDL, LDL, cholesterol, triglyceride TSH, free T4, ALT, AST levels were measured. HOMA-IR and atherogenic index (AI) were calculated. Results: Prevalence of SH was estimated as 14.1 %. The values of fasting glucose, fasting insülin, ALT, AST, TSH, HOMA-IR levels were significantly higher ın SH group than euthyroid group. There was a positive correlation between TSH and fasting glucose, insülin, triglyceride, ALT, AST, HOMA-IR, AI. It was also demonstrated that the TSH level was significantly and independently related to HOMA-IR value ın multiple regression analysis (p=0.001). Conclusions: Obese patients with SH may be more susceptible to metabolic complications than euthyroid subjects.

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“… 7 8 Other causes of anovulation, such as thyroid disease, hyperprolactinemia, and congenital adrenal hyperplasia, also associated with cardiovascular disease in both young and old patients. 9 10 11 12 13 14 15 No study has followed these group of anovulatory patients from their reproductive stage until they pass through menopause. So, how anovulation/PCOS affects menopause is still unknown.…”

Section: Introductionmentioning

confidence: 99%

The Association between Oligomenorrhea, Onset of Menopause and Metabolic Syndrome in Thai Postmenopausal Women

et al. 2018

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ObjectivesThis study explored the association between a history of oligomenorrhea and onset of menopause and metabolic parameters.MethodsThe study population was 605 postmenopausal women who were patients at the Menopause Clinic, Maharaj Nakorn Chiang Mai Hospital, Chiang Mai, Thailand between February 2015 and December 2015. A questionnaire was used to ask all women about their history of oligomenorrhea. The study also collected medical data, including weight, height, waist circumference, blood pressure, and blood glucose and lipid profile.ResultsOf the 231 postmenopausal women with a complete data record, 31 had a history of oligomenorrhea and 200 did not. The age of onset of menopause was around 48 years in both groups. Prevalence of metabolic syndrome was 12.1%. More women with a waist circumference larger than 80 cm had a history of oligomenorrhea at the interview than women who had not, but a history of oligomenorrhea did not relate to other metabolic parameters. The adjusted odds ratio of a history of oligomenorrhea to waist circumference was 3.69 (95% confidence interval, 1.17–11.64).ConclusionsA history of oligomenorrhea did not affect the age at menopause, but was associated with waist circumference during menopause.

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Serum TSH levels are associated with cardiovascular risk factors in overweight and obese adolescents

Cited by 11 publications

References 30 publications

The association of thyroid-stimulating hormone (TSH) and free thyroxine (fT4) concentration levels with carbohydrate and lipid metabolism in obese and overweight teenagers.

The association of thyroid-stimulating hormone (TSH) and free thyroxine (fT4) concentration levels with carbohydrate and lipid metabolism in obese and overweight teenagers.

The prevalence of subclinical hypothyroidism in obese children and adolescents and its effects on metabolic parameters

The Association between Oligomenorrhea, Onset of Menopause and Metabolic Syndrome in Thai Postmenopausal Women

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