The association of thyroid-stimulating hormone (TSH) and free thyroxine (fT4) concentration levels with carbohydrate and lipid metabolism in obese and overweight teenagers.

Abstract

Introduction: Obesity has increased rapidly among children and adolescents during the last 30 years. Paediatric patients with a BMI above the 85 th centile are more often diagnosed with increased TSH levels than are children with proper body weight. Material and methods: The data of 961 overweight and obese children, aged 13 years, recruited in four cities in Poland as part of PoZdro!, a two-year prophylactic program, were analysed to observe the relationship between serum TSH and fT4 concentration and carbohydrate and lipid metabolism parameters, as well as anthropometric parameters. Results: TSH concentration in the study group was positively correlated, whereas fT4 concentration was negatively correlated with WHR and WHtR values, fasting serum glucose concentrations and one-hour glucose concentration, fasting serum insulin concentrations, one-hour and two-hour insulin concentration, ALT serum activity, as well as total cholesterol, LDL cholesterol, and triglyceride serum concentrations. An increased risk of metabolic syndrome was diagnosed previously in patients with TSH concentrations > 2.5 mUI/L. Conclusions: TSH concentration in the upper half of the current reference range (> 2.50 mIU/L) is associated with an increased risk of lipid and carbohydrate metabolism disorders and therefore increased chances of developing metabolic syndrome. It seems advisable to regularly monitor thyroid function in overweight and obese paediatric patients.

The prevalence and related factors of metabolic syndrome in outpatients with first-episode drug-naive major depression comorbid with anxiety

“…In recent years, the relationship between thyroid hormone and MetS has been a focus of research. Many studies have found that a high TSH level within the normal range is related to MetS 28 , 56 , 57 , 58 . A study by Ren et al found that MetS components, such as BMI, body weight, blood pressure, and blood lipids, are affected by TSH levels 59 .…”

Leptin Does Not Influence TSH Levels in Obese Short Children

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Thyroid Function and the Risk of Prediabetes and Type 2 Diabetes

“…In addition, thyroid hormones may cause pathological conditions that in turn act as risk factors for type 2 diabetes, such as an increased body mass index and impaired insulin secretion ( 6 , 28 ). For example, an association between low FT4 and insulin resistance has been reported in euthyroid participants ( 29 ), and low FT4 levels have been found to be related to metabolic syndrome ( 30 ). In this study, after pooling the findings of 3 studies, we describe a relation between lower levels of FT4 within the reference range and a higher risk of developing type 2 diabetes ( 9 , 15 ).…”