Serum Triglycerides and Risk of Coronary Heart Disease among Japanese Men and Women

Abstract

To examine the relation of triglycerides with coronary heart disease among populations with low mean total cholesterol, the authors conducted a 15.5-year prospective study ending in 1997 of 11,068 Japanese aged 40-69 years (4,452 men and 6,616 women with mean total cholesterol = 4.73 mmol/liter and 5.03 mmol/liter, respectively), initially free of coronary heart disease or stroke. There were 236 coronary heart disease events comprising 133 myocardial infarctions, 68 angina pectoris events, and 44 sudden cardiac deaths. The coronary heart disease incidence was greater in a dose-response manner across increasing quartiles of nonfasting triglycerides for both sexes. The multivariate relative risk of coronary heart disease adjusting for coronary risk factors and time since last meal associated with a 1-mmol/liter increase in triglycerides was 1.29 (95% confidence interval (CI): 1.09, 1.53; p = 0.004) for men and 1.42 (95% CI: 1.15, 1.75; p = 0.001) for women. The trend was similar for myocardial infarction, angina pectoris, and sudden cardiac death. The relation of triglycerides with coronary heart disease was not influenced materially by total cholesterol levels or, in a subsample analysis (51% of total sample), by high density lipoprotein cholesterol levels. Nonfasting serum triglycerides predict the incidence of coronary heart disease among Japanese men and women who possess low mean values of total cholesterol. Further adjustment for high density lipoprotein cholesterol suggests an independent role of triglycerides on the coronary heart disease risk.

The impact of the metabolic syndrome and its components on the incidence of ischemic heart disease and stroke: the Japan public health center-based study

“…Although the justification for the use of the same cutoff point as fasting status is debated, the data represented by nonfasting triglycerides can be used because of its significant predictive ability with regard to ischemic heart disease. 35 In conclusion, this study provides epidemiological evidence that the metabolic syndrome was associated with the risks of ischemic heart disease and ischemic stroke, but not with the risk of hemorrhagic stroke. The metabolic syndrome based on the AHA/NHLBI criteria predicts the risk of ischemic cardiovascular disease better than that based on the IDF criteria among less-obese populations.…”

Risk Factors and the Incidence of Coronary Artery Disease in Young Middleaged Japanese Men: Results from a 10Year Cohort Study

“…Even though TG is a well known risk factor for atherosclerosis (20), a few previous studies reported the relation between nonfasting TG and CAD in Japanese population (10) …”

The Role of Triglyceride in Cardiovascular Disease in Asian Patients with Type 2 Diabetes - A Systematic Review

“…Studies conducted in Taiwan have also suggested that triglyceride is associated with hypertension in patients with T2DM and may also be associated with the progression of albuminuria [13,14]. Indeed, in the Asian population, hypertriglyceridemia may be more important than LDL-C as a risk factor for CVD in diabetic patients and non-diabetic patients [15][16][17]. In this article, we review the role of TG in CVD in patients with T2DM in Asian populations.…”