The Role of Triglyceride in Cardiovascular Disease in Asian Patients with Type 2 Diabetes - A Systematic Review

Chen, Aihua; Tseng, Chin‐Hsiao

doi:10.1900/rds.2013.10.101

Cited by 29 publications

(23 citation statements)

References 55 publications

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“…58,59 However, the role of triglycerides as a risk factor for developing CAD in type 2 diabetics is still unclear. 60 Our data showing higher triglycerides level in T2D subjects with CAD indicating an important role of triglycerides in susceptibility to CAD and lowering of this molecule would possibly reduce the risk of heart diseases in T2D subjects.…”

Section: Discussionmentioning

confidence: 60%

Diminished 25‐OH vitamin D₃ levels and vitamin D receptor variants are associated with susceptibility to type 2 diabetes with coronary artery diseases

Wang²,

Chen

et al. 2019

Clinical Laboratory Analysis

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Background: Role of plasma vitamin D and genetic variants of its receptor (VDR) in susceptibility to different diseases has been documented. Various studies in different populations have been highlighted strong associations with diabetes and cardiovascular diseases. Vitamin D deficiency has been linked with the development of type 2 diabetes (T2D) and the onset of coronary artery diseases (CAD). However, the role of vitamin D in predisposition to CAD in patients with T2D is ill-defined. Materials and Methods:We enrolled 674 Chinese T2D patients, and based on clinical phenotype, patients were further categorized into patients with (n = 138) or without coronary artery disease (n = 536). Five hundred twenty-one healthy subjects from similar geographical areas, free from diabetic or coronary disorders, were enrolled as controls. Serum levels of 25-OH vitamin D were quantified by ELISA. Common VDR (FokI, TaqI, BsmI, and ApaI) polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: Patients with T2D displayed lower levels of 25-OH vitamin D comparedwith healthy controls. Furthermore, T2D patients with CAD clinical phenotype had the lowest levels of vitamin D. Prevalence of FokI and TaqI mutants was significantly higher in diabetic patients when compared to controls. Interestingly, Tt genotype was more frequent in the artery disease group in comparison with T2D patients without heart involvement. Combined analysis of VDR polymorphisms and serum levels of vitamin D revealed a significant role in predisposition to T2D with or without CAD. Conclusions: Lower vitamin D levels and variants of VDR polymorphisms (FokI andTaqI) are associated with susceptibility to T2D and clinical manifestation. K E Y W O R D SChinese, coronary artery disease; vitamin D, polymorphism, Type-2 diabetes, vitamin D receptor

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Section: Discussionmentioning

confidence: 60%

Diminished 25‐OH vitamin D₃ levels and vitamin D receptor variants are associated with susceptibility to type 2 diabetes with coronary artery diseases

Wang²,

Chen

et al. 2019

Clinical Laboratory Analysis

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“…Its family consisted of Trx, TR, and Trx peroxidase. Trx has two configurations: oxidized Trx (Trx-S 2 ) and reduced Trx [Trx-(SH) 2 ]. The reduced Trx may be transformed into oxidized Trx in the progress of scavenging free radicals.…”

Section: Discussionmentioning

confidence: 99%

“…Although people of the middleaged and the elderly are more likely to develop T2DM, it alarms us that there are an increasing number of young T2DM patients [1]. Among the diabetic complications, cardiac event is the highest risk, and it has become a leading cause of death of diabetes [2]. The resistance of myocardial cells to injury was reduced in diabetes.…”

Section: Introductionmentioning

confidence: 99%

Variations of thioredoxin system contributes to increased susceptibility to apoptosis in cardiomyocytes of type 2 diabetic rats

Zhao¹,

Zhang²,

Li³

et al. 2014

ABBS

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Cardiac complications are the leading cause of death in diabetes. However, the mechanism of diabetes in inducing myocardial injury and apoptosis, and whether the thioredoxin (Trx) system is involved remain unclear. In this study, male Sprague -Dawley rats were randomly divided into two groups: the control and the diabetes groups, and then were randomly divided into five different timepoints (the 1st, 2nd, 4th, 12th, and 24th week). The results showed that diabetes-induced cardiac injury was enhanced in the type 2 diabetes rats, as evidenced by aggravated cardiac dysfunction, biochemical indicators, and increased myocardial apoptosis (TUNEL and caspase-3 activity). The activity of myocardial Trx and Trx reductase (TR) in diabetic rats was significantly decreased from the second week and continually aggravated with the disease progression. In diabetic rats, the mRNA expression of Trx1, Trx2, TR1, and TR2 was decreased first and then increased after the fourth week. Meanwhile, the protein expression of these Trx system members was significantly increased at the 12th week. Trx nitration was cleared, the Trx/ASK1 interaction was significantly decreased, and the activity of p38 was significantly enhanced in cardiac tissues at the 12th week. These results demonstrated that diabetes may cause myocardial injury and apoptosis, and the extent of which was accompanied with the development of the disease. The mechanism is associated with the development of diabetes and the decreased activity of Trx and TR. The reasons for decreased Trx activity may include: decrease of Trx and TR protein expression; nitration modification of Trx; and up-regulation of TXNIP expression.

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“…Obesity and diabetes are comorbid disorders, with dysfunction of lipid metabolism. Hyperlipidemia contributes to the development of IR and T2DM (Unick et al, 2011), as well as cardiovascular diseases (McTigue et al, 2006;Chen and Tseng, 2013;Chehade et al, 2013;Reiner, 2013). Since Danshen and Sanqi are reported to ameliorate lipid metabolism disorders Xia et al, 2011) when treating cardiovascular diseases (Cheng, 2007).…”

Section: Introductionmentioning

confidence: 99%

Dan-Qi prescription ameliorates insulin resistance through overall corrective regulation of glucose and fat metabolism

Xie

Truong

Zhang

et al. 2015

Journal of Ethnopharmacology

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The Role of Triglyceride in Cardiovascular Disease in Asian Patients with Type 2 Diabetes - A Systematic Review

Cited by 29 publications

References 55 publications

Diminished 25‐OH vitamin D₃ levels and vitamin D receptor variants are associated with susceptibility to type 2 diabetes with coronary artery diseases

Diminished 25‐OH vitamin D₃ levels and vitamin D receptor variants are associated with susceptibility to type 2 diabetes with coronary artery diseases

Variations of thioredoxin system contributes to increased susceptibility to apoptosis in cardiomyocytes of type 2 diabetic rats

Dan-Qi prescription ameliorates insulin resistance through overall corrective regulation of glucose and fat metabolism

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The Role of Triglyceride in Cardiovascular Disease in Asian Patients with Type 2 Diabetes - A Systematic Review

Cited by 29 publications

References 55 publications

Diminished 25‐OH vitamin D3 levels and vitamin D receptor variants are associated with susceptibility to type 2 diabetes with coronary artery diseases

Diminished 25‐OH vitamin D3 levels and vitamin D receptor variants are associated with susceptibility to type 2 diabetes with coronary artery diseases

Variations of thioredoxin system contributes to increased susceptibility to apoptosis in cardiomyocytes of type 2 diabetic rats

Dan-Qi prescription ameliorates insulin resistance through overall corrective regulation of glucose and fat metabolism

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Diminished 25‐OH vitamin D₃ levels and vitamin D receptor variants are associated with susceptibility to type 2 diabetes with coronary artery diseases

Diminished 25‐OH vitamin D₃ levels and vitamin D receptor variants are associated with susceptibility to type 2 diabetes with coronary artery diseases