Dan-Qi prescription ameliorates insulin resistance through overall corrective regulation of glucose and fat metabolism

Xie, Zhishen; Truong, Thanh Loi; Zhang, Pei; Xu, Fengguo; Xu, Xiaojun; Li, Ping

doi:10.1016/j.jep.2015.05.041

Cited by 34 publications

(29 citation statements)

References 39 publications

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“…The increased prevalence of obesity has focused attention on a worldwide problem that is not one of famine or infection, but one of surplus. Increasing research results show ginseng and ginsenoside Rb1 possess anti-obesity [71], anti-hyperglycemic [72,73], insulin-sensitizing [74], and anti-diabetic properties [75,76], which may be mainly realized by improving glucose tolerance, reducing hepatic fat accumulation [59,64], increasing the sensitivity of insulin, exhibiting adjuvant treatment, suppressing adipocyte lipolysis [77], and regulating adipocyte development and functions [64,73,75]. These effects contribute to the treatment of diabetes and delay in the development and progression of diabetic complications.…”

Section: Anti-diabetic Effects and Mechanisms Of Ginsenoside Rb1mentioning

confidence: 99%

Ginsenoside Rb1 as an Anti-Diabetic Agent and Its Underlying Mechanism Analysis

Zhou

Xie

et al. 2019

Cells

207

127

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Panax ginseng and Panax notoginseng, two well-known medical plants with economic value, have a long history of use for managing various diseases in Asian countries. Accumulating clinical and experimental evidence suggests that notoginsenosides and ginsenosides, which are the major bioactive components of the plants, have a variety of beneficial effects on several types of disease, including metabolic, vascular, and central nervous system disease. Considerable attention has been focused on ginsenoside Rb1 derived from their common ownership as an anti-diabetic agent that can attenuate insulin resistance and various complications. Particularly, in vitro and in vivo models have suggested that ginsenoside Rb1 exerts various pharmacological effects on metabolic disorders, including attenuation of glycemia, hypertension, and hyperlipidemia, which depend on the modulation of oxidative stress, inflammatory response, autophagy, and anti-apoptosis effects. Regulation of these pathophysiological mechanisms can improve blood glucose and insulin resistance and protect against macrovascular/microvascular related complications. This review summarizes the pharmacological effects and mechanisms of action of ginsenoside Rb1 in the management of diabetes or diabetic complications. Moreover, a multi-target effect and mechanism analysis of its antidiabetic actions were performed to provide a theoretical basis for further pharmacological studies and new drug development for clinical treatment of type 2 diabetes. In conclusion, ginsenoside Rb1 exerts significant anti-obesity, anti-hyperglycemic, and anti-diabetic effects by regulating the effects of glycolipid metabolism and improving insulin and leptin sensitivities. All of these findings suggest ginsenoside Rb1 exerts protective effects on diabetes and diabetic complications by the regulation of mitochondrial energy metabolism, improving insulin resistance and alleviating the occurrence complications, which should be further explored. Hence, ginsenoside Rb1 may be developed as a potential anti-obesity, anti-hyperglycemic, and anti-diabetic agent with multi-target effects.

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Section: Anti-diabetic Effects and Mechanisms Of Ginsenoside Rb1mentioning

confidence: 99%

Ginsenoside Rb1 as an Anti-Diabetic Agent and Its Underlying Mechanism Analysis

Zhou

Xie

et al. 2019

Cells

207

127

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“…In this direction, our data proved the ability of ginseng to improve insulin sensitivity in diabetic rats. There were many studies that have demonstrated the effect of ginseng on GLUTs, it have been reported that ginseng induced translocation of GLUT4 (Tabandeh et al, 2015, Ota and Ulrih, 2017), up-regulation of GLUT4 in muscles of diabetic rats (Lai et al, 2006, Kang et al, 2017), high expression levels of GLUT1 and GLUT4 in myotubes of diabetic rats (Seo et al, 2016), increase the expression of GLUT1 and GLUT4 in livers of diabetic mice (Jung and Kang, 2013, Xie et al, 2015), , and up-regulation of GLUT4 in adipose tissue of diabetic rats (Kim and Kim, 2012). Regarding GLUT2 mRNA expression levels our data come in the same line of (Kang et al, 2017) which demonstrated the high expression levels of hepatic GLUT2 hand by hand with high phosphorylation of AMPK in diabetic mice received ginseng for 4 weeks.…”

Section: Discussionmentioning

confidence: 99%

“…In our study, ginseng activated both GK and GS in diabetic rats. Ginseng has to increase GK expression in adipocytes (Lee et al, 2017a) and induced the expression of GK in pancreatic cells (Park et al, 2008), in the same line, ginseng have to increase hepatic or muscles glycogen deposition (Xie et al, 2015, Xu and Dou, 2016) through inhibition of Glycogen synthase kinase (GSK) in hepatocytes (Kho et al, 2016, Zhang et al, 2016, Shi et al, 2018). Others conclude that ginseng have to suppress the expression of GS (Seo et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Panax ginseng improves glucose metabolism in streptozotocin-induced diabetic rats through 5′ adenosine monophosphate kinase up-regulation

Abdelazim

Khater

Ali

et al. 2019

Saudi Journal of Biological Sciences

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5′ AMP-activated protein kinase (AMPK), insulin receptors and transporters are distorted in diabetes mellitus. In this study, the effect of Panax ginseng was assessed on glucose manipulating enzymes activities and gene expression of AMPK, IRA and GLUT2 in streptozotocin-induced diabetic male rats. Forty male albino rats were randomly divided to four groups 10 rats of each, group I, normal control group (received saline orally); group II, normal rats received 200 mg/kg of Panax ginseng orally; group III, Streptozotocin (STZ) –induced diabetic rats and group IV, STZ-induced diabetic rats received 200 mg/kg of Panax ginseng orally. The duration of experiment was 30 days. Results showed the ability of Panax ginseng to induce a significant decrease in the blood glucose and increase in the serum insulin levels, hepatic glucokinase (GK), and glycogen synthase (GS) activities with a modulation of lipid profile besides high expression levels of AMPK, insulin receptor A (IRA), glucose transporting protein-2 (GLUT-2) in liver of diabetic rats. In conclusion, the obtained results point to the ability of Panax ginseng to improve the glucose metabolism in diabetic models.

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“…Chen (Sanqi) belonging to the family Araliaceae is a famous traditional Chinese herbal medicine with multi‐pharmacological activities . Many traditional Chinese medicine prescriptions containing P. notoginseng , such as Xue‐Shan‐Tong injection , Xue‐Sai‐Tong capsule , and Dan‐Qi tablet have been used to prevent and treat cardiovascular diseases and other disorders in China. P. notoginseng has also been marketed in the form of dietary supplements or functional foods in European countries and the United States .…”

Section: Introductionmentioning

confidence: 99%

Identification and characterization of forced degradation products and stability‐indicating assay for notoginsenosidefc by using UHPLC‐Q‐TOF‐MS and UHPLC‐MS/MS: Insights into stability profile and degradation pathways

Ma¹,

Guan²,

Ju³

et al. 2019

J of Separation Science

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Notoginsenoside Fc, a protopanaxadiol-type saponin, shows multi-pharmacological activities. Chemical stability evaluation plays a crucial role in drug development.In this study, the forced degradation behavior of Notoginsenoside Fc was investigated under hydrolytic and oxidative conditions. A specific ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry was developed for the separation, identification, and characterization of the degradation products of Notoginsenoside Fc. Fifty potential degradation products were formed via deglycosylation, dehydration, hydration, isomerization, side-chain cleaving, oxidation, and superoxidation. Notoginsenoside Fc was subjected to different pH solutions, temperatures, and time periods to assess its stability. A sensitive ultra high performance liquid chromatography-tandem mass spectrometry was developed for the quantification of Notoginsenoside Fc, notoginsenoside ST-4, notoginsenoside Ft1, and relative quantification of notoginsenoside Ft2, 20(R)-notoginsenoside Ft2, notoginsenoside SFt3, and notoginsenoside SFt4. The assay was linear over the concentration range (R 2 > 0.997) with the lowest limit of quantification of 0.02 μg/mL for Notoginsenoside Fc, Notoginsenoside ST-4, and Notoginsenoside Ft1. The intra-day precision, inter-day precision, and accuracy of the three analytes were within accepted levels. The degradation kinetics of Notoginsenoside Fc in pH 1 and 3 solutions fits to first-and second-order kinetics, respectively. The degradation of Notoginsenoside Fc is pH-, temperature-, and time-dependent.

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Dan-Qi prescription ameliorates insulin resistance through overall corrective regulation of glucose and fat metabolism

Cited by 34 publications

References 39 publications

Ginsenoside Rb1 as an Anti-Diabetic Agent and Its Underlying Mechanism Analysis

Ginsenoside Rb1 as an Anti-Diabetic Agent and Its Underlying Mechanism Analysis

Panax ginseng improves glucose metabolism in streptozotocin-induced diabetic rats through 5′ adenosine monophosphate kinase up-regulation

Identification and characterization of forced degradation products and stability‐indicating assay for notoginsenosidefc by using UHPLC‐Q‐TOF‐MS and UHPLC‐MS/MS: Insights into stability profile and degradation pathways

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