Serum Trace Element Levels in Tuberculous Pleurisy

Wang, Guangqiang; Ma, Lin

doi:10.1007/s12011-010-8722-1

Cited by 7 publications

(4 citation statements)

References 21 publications

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“…Diversos estudos relatam redução e/ou alteração de micronutrientes em doenças crôni-cas, dentre elas a hanseníase [23][24][25][26] . O desequilíbrio de micronutrientes pode gerar prejuízos à função celular, fisiológica e imunológica, sendo tais alterações associadas à causa ou à consequência de inúmeras doenças 27 .…”

Section: I S C U S S ã Ounclassified

Estresse oxidativo e micronutrientes na hanseníase

Oliveira

Júnior

et al. 2015

Rev. Nutr.

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Objetivo Avaliar o estresse oxidativo, perfil antioxidante e de micronutrientes em pacientes portadores de hanseníase multibacilar e paucibacilar antes do tratamento poliquimioterápico. Métodos Analisaram-se 52 amostras de soro de pacientes portadores de hanseníase - 38 multibacilares e 14 paucibacilares -, usuários do ambulatório de dermatologia de um hospital público universitário, além de 30 amostras controles. Quantificaram-se marcador de peroxidação lipídica malondialdeído pelo método de substâncias reativas ao ácido tiobarbitúrico, antioxidante glutationa reduzida pelo método baseado na quantificação de tiol solúvel em ácido, antioxidante vitamina E por cromatografia líquida de alta eficiência, minerais selênio, zinco, cobre, magnésio por espectrometria de massa com fonte plasma acoplado, e sorologia do anticorpo glicolipídio fenólico I pelo método Enzyme-Linked Immunosorbent Assay. Foi utilizado teste não paramétrico de Mann-Whitney para comparar as variáveis quantificadas neste estudo entre os diferentes grupos, e correlação de Pearson para verificar associação dessas variáveis com o anticorpo. O critério de significância adotado foi de p<0,05. Resultados Houve diferença significativa para o malondialdeído (p<0,001) e vitamina E (p<0,001) no grupo controle comparado aos grupos com hanseníase, multibacilar e paucibacilar. No entanto, essas mesmas variáveis não diferiram entre os grupos multibacilar e paucibacilar (p=0,495 e p=0,920 respectivamente). A glutationa reduzida foi superior no grupo controle em relação ao grupo com hanseníase (p=0,012) e multibacilar (p=0,001), no entanto não diferiu do grupo paucibacilar (p=0,920). Quando comparada com os multibacilares e paucibacilares, a glutationa reduzida também não diferiu (p=0,063). Quanto aos minerais, todos se apresentaram dentro da normalidade, exceto o magnésio, cujos níveis foram deficientes em todos os pacientes do estudo. Não foi possível observar correlação do anticorpo glicolipídio fenólico I com as demais variáveis. Conclusão Os pacientes paucibacilares parecem possuir maior defesa antioxidante de glutationa reduzida, semelhante à de indivíduos saudáveis. Baixos níveis de vitamina E nos pacientes com hanseníase são sugestivos dos benefícios de suplementação. As alterações metabólicas observadas não evidenciaram relação com a sorologia do glicolipídio fenólico I.

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Section: I S C U S S ã Ounclassified

Estresse oxidativo e micronutrientes na hanseníase

Oliveira

Júnior

et al. 2015

Rev. Nutr.

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“…ZIP8 is elevated in circulating peripheral blood monocytes during the acute phase response, which is associated with reduced serum zinc concentrations [ 86 ]. Similarly, circulating levels of zinc in plasma or serum are reduced in patients with active TB [ 90 , 91 , 92 ]. In time, zinc levels recover with antibiotic therapy in the absence of zinc supplementation [ 90 , 93 ], indicating that, similar to iron, the intracellular redistribution of vascular zinc occurs in TB.…”

Section: Implications Of Zip8 Induction On Tbmentioning

confidence: 99%

Elemental Ingredients in the Macrophage Cocktail: Role of ZIP8 in Host Response to Mycobacterium tuberculosis

Pyle

Azad

Papp

et al. 2017

IJMS

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Tuberculosis (TB) is a global epidemic caused by the infection of human macrophages with the world’s most deadly single bacterial pathogen, Mycobacterium tuberculosis (M.tb). M.tb resides in a phagosomal niche within macrophages, where trace element concentrations impact the immune response, bacterial metal metabolism, and bacterial survival. The manipulation of micronutrients is a critical mechanism of host defense against infection. In particular, the human zinc transporter Zrt-/Irt-like protein 8 (ZIP8), one of 14 ZIP family members, is important in the flux of divalent cations, including zinc, into the cytoplasm of macrophages. It also has been observed to exist on the membrane of cellular organelles, where it can serve as an efflux pump that transports zinc into the cytosol. ZIP8 is highly inducible in response to M.tb infection of macrophages, and we have observed its localization to the M.tb phagosome. The expression, localization, and function of ZIP8 and other divalent cation transporters within macrophages have important implications for TB prevention and dissemination and warrant further study. In particular, given the importance of zinc as an essential nutrient required for humans and M.tb, it is not yet clear whether ZIP-guided zinc transport serves as a host protective factor or, rather, is targeted by M.tb to enable its phagosomal survival.

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“…We have evaluated the levels of copper (Cu), zinc (Zn), magnesium (Mg), manganese (Mn), selenium (Se), and iron (Fe) in the serum of patients with (TB) pleurisy [13]. The significant increase in the serum copper and the decrease in serum selenium, magnesium, and zinc in the pleural patient may be indicative of an interrelationship of these elements and TB pleurisy risk (Table 1).…”

mentioning

confidence: 99%

Trace Elements Analysis of Urine and Hair in Tuberculous Pleurisy

Wang

2011

Biol Trace Elem Res

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In this study, copper, zinc, magnesium, manganese, selenium, and iron of urine and hair were measured in the patients with tuberculous (TB) pleurisy (n = 24) and in the control group (n = 20). Selenium, magnesium, and zinc of hair were found to be significantly lower in TB pleurisy cases than those in the control group (p < 0.05, p < 0.001, and p < 0.01, respectively). On the contrary, selenium and magnesium of urine were found to be significantly elevated in TB pleurisy cases than those in the control group (p < 0.05 and p < 0.001, respectively). There was no significant difference in the value of manganese and iron between TB pleurisy and the control group (p > 0.05). Copper level were significantly increased in hair and decreased in urine of the patients (p < 0.01). The occurrence of these abnormalities constitutes new information regarding trace elements in TB pleurisy patients. These results may provide an additional disease correlate for assessing TB pleurisy risk.

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Serum Trace Element Levels in Tuberculous Pleurisy

Cited by 7 publications

References 21 publications

Estresse oxidativo e micronutrientes na hanseníase

Estresse oxidativo e micronutrientes na hanseníase

Elemental Ingredients in the Macrophage Cocktail: Role of ZIP8 in Host Response to Mycobacterium tuberculosis

Trace Elements Analysis of Urine and Hair in Tuberculous Pleurisy

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