Serum TNF-α in psoriasis after treatment with propylthiouracil, an antithyroid thioureylene

Elias, Alan N.; Nanda, V.; Pandian, Raj

doi:10.1186/1471-5945-4-4

Cited by 7 publications

(9 citation statements)

References 28 publications

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“…In addition, Nakamura et al [26] recorded a higher mean TNF-a serum level in patients with pustular psoriasis and palmoplantar pustulosis than controls. Moreover, TNF-a and its receptors play important roles in the development and persistence of psoriatic plaques [27]. In contrast to our finding is that of Tigalonova et al [28], who reported that the serum level of TNF-a did not differ between the psoriasis and the control groups.…”

Section: Discussioncontrasting

confidence: 99%

Study of tumor necrosis factor-α-308 promoter polymorphism in psoriasis vulgaris

El-Farargy¹,

Farag²,

Azmy³

et al. 2014

Journal of the Egyptian Womenʼs Dermatologic Society

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Section: Discussioncontrasting

confidence: 99%

Study of tumor necrosis factor-α-308 promoter polymorphism in psoriasis vulgaris

El-Farargy¹,

Farag²,

Azmy³

et al. 2014

Journal of the Egyptian Womenʼs Dermatologic Society

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“…Although mucosal involvements are rare, they are related to pustular, plaque-type and erythrodermic skin involvements. Also, various lesions have been described including white, yellowish, grey or translucent plaques, annular forms or diffuse areas of erythema and geographic tongue [ 12 , 13 ]. Although there is controversy about the occurrence of psoriatic lesions on oral mucous membranes, the results of a recent review showed that the prevalence of fissured tongue was ranging from 9.8% to 47.5% and geographic tongue occurred between 5.6% and 18.1% of patients with psoriatic disease [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Oral Mucosal Lesions and Their Association with Severity of Psoriasis among Psoriatic Patients Referred To Dermatology Clinic: A Cross-Sectional Study in Kashan/Iran

Talaee¹,

Hajheydari²,

Moghaddam³

et al. 2017

Open Access Maced J Med Sci

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BACKGROUND:Psoriasis is a common inflammatory papulosquamous disease of the skin with unknown aetiology that may be associated with the abnormal T-cell function.AIM:This study was aimed to determine the prevalence of oral mucosal lesions and their associations with severity of psoriasis in psoriatic patients attending the dermatologic clinic of Shahid Beheshti Teaching Hospital at Kashan, Iran.METHODS:In this cross-sectional descriptive analytic study, all consecutive patients with psoriasis who referred to the dermatologic clinic at the Shahid Beheshti Hospital of Kashan University of Medical Sciences in Kashan City/ Iran were enrolled. All patients were examined for the presence of oral lesions, and the clinical and epidemiological features of the disease were recorded in a questionnaire for each patient. A biopsy was taken from atypical suspected patients with oral lesions by an expert dermatologist. Data were analysed using the Statistical Package for Social Science (Version 18). Descriptive statistics tests; Cross tabulation and Chi-square with Fisher’s exact test were used.RESULTS:Of total 177 psoriatic patients, 62 cases (35%) of patients were male, and 115 cases (65%) were female. Mean age of patients was 31.71 years. The oral lesion was seen in 83 cases (46.9%). Fissure tongue (28.2%) and geographic tongue (4.5%) were the most common oral lesions. The prevalence of oral lesions in patients with psoriasis significantly was associated with age, history of oral lesions, and with the onset of the oral lesions (P < 0.05). The most common form of psoriasis was chronic plaque form (Psoriasis Vulgaris) observed in 147 cases (83.1). The majority of patients (67.2%) were suffering from a mild form of the disease. Psoriasis Area and Severity Index (PASI) score of most patients was mild.CONCLUSIONS:The prevalence of oral lesions such as Fissure tongue and geographic tongue is higher in psoriatic patients suggests further studies for approving the clinical importance of these apparently nonspecific lesions as possible predictors or markers of the severity of the cases suspected to Psoriasis disease.

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“…Also, Kızıltunc et al [9] reported that IL-6 and TNF-α serum levels were decreased in humans who suffered owing to hypothyroidism. Contrarily to these data, PTU did not cause any alteration in circulating levels of TNF-α in human [10] nor in rats [11] . …”

Section: Discussionmentioning

confidence: 69%

Tiroidektomize Ratlarda Serum IL-1β, IL-6, IL-10 ve TNF-α Seviyeleri

Kandir¹,

Keskin²

2015

Kafkas Univ Vet Fak Derg

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This study was conducted to determine the serum levels of interleukin (IL)-1β, IL-6, IL-10 and tumor necrosis factor alpha (TNF-α) in thyroidectomized rats. Hypothyroidism was performed by surgical thyroidectomy in rats. Four weeks after from surgical procedure, selected cytokines levels were evaluated. Hypothyroidism was confirmed by elevated thyroid stimulating hormone (TSH) and decreased free tri-iodothyronine (fT3) levels (P<0.05) in thyroidectomized group. Serum IL-1β, IL-6, IL-10 levels have shown slight increase, whereas only TNF-α level (P<0.05) were significant statistically in thyroidectomized rats compared with control group. In conclusion, the obtained data suggest that elevated levels of cytokines could be as a consequence of thyroidectomy operation. Keywords: Cytokine, Immune function, Rodent, Thyroid alteration, Trauma Tiroidektomize Ratlarda Serum IL-1β, IL-6, IL-10 ve TNF-α Seviyeleri ÖzetBu çalışmada, tiroidektomize ratların serum interlökin (IL)-1β, IL-6, IL-10 and TNF-α düzeylerinin belirlenmesi amaçlanmıştır. Hipotiroidizm cerrahi yolla tiroidektomi yapılarak gerçekleştirildi. Cerrahi işlemden sonraki 4. haftada, seçili sitokinlerin seviyeleri ölçüldü. Hipotiroidizm, tiroidektomize grubun tiroid uyarıcı hormon (TSH) düzeyindeki artış (P<0.05) ve serbest tri-iyodotironin (fT3) düzeyindeki azalış (P<0.05) ile teyit edildi. Tiroidektomize ratların serum IL-1β, IL-6, IL-10 seviyelerinin kontrol grubuna kıyasla hafif düzeyde yükseldiği ancak, sadece TNF-α düzeyindeki artışın istatistiki olarak anlamlı (P<0.05) olduğu görüldü. Sonuç olarak elde edilen veriler, sitokin seviyelerindeki yükselmenin, tiroidektomi operasyonunun bir sonucu olabileceğini düşündürmektedir.

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Serum TNF-α in psoriasis after treatment with propylthiouracil, an antithyroid thioureylene

Cited by 7 publications

References 28 publications

Study of tumor necrosis factor-α-308 promoter polymorphism in psoriasis vulgaris

Study of tumor necrosis factor-α-308 promoter polymorphism in psoriasis vulgaris

Prevalence of Oral Mucosal Lesions and Their Association with Severity of Psoriasis among Psoriatic Patients Referred To Dermatology Clinic: A Cross-Sectional Study in Kashan/Iran

Tiroidektomize Ratlarda Serum IL-1β, IL-6, IL-10 ve TNF-α Seviyeleri

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