Tiroidektomize Ratlarda Serum IL-1β, IL-6, IL-10 ve TNF-α Seviyeleri

Kandir, Sinan; Keskin, Ercan

doi:10.9775/kvfd.2015.14371

Cited by 5 publications

(1 citation statement)

References 16 publications

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“…Thus, TNF-α, IL-6, IL-4, and IL-13 are implicated in the pathogenesis of EPS. Elevated levels of TNF-α and IL-10 are known to trigger the expression of reactive astrocytes, leading to cell death and tissue degeneration [52][53][54][55]. Recent studies have unraveled molecular mechanisms, including the activity of inducible nitric oxide synthase (iNOS) and pro-in ammatory cytokines that modulate transcriptional programs in astrocytes associated with degenerative or protective functions [56][57][58].…”

Section: Discussionmentioning

confidence: 99%

Synergistic Action of Vitamin D3 and A Protects Motor Activity by Regulating Reactive Astrocytes, Inflammatory Cytokines, and Dopaminergic Activity in the Corticobasal Loop of a Mice Model of Extrapyramidal Syndrome

Sirajo,

Maigari,

Sunusi

et al. 2023

Preprint

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Background: Extrapyramidal syndromes (EPS) represent neurological side effects of antipsychotic medications, characterized by motor disturbances. While previous studies have indicated the neuroprotective effects of vitamin D and A against EPS, the underlying mechanisms of this protection remain unclear.Methods: Twenty-four adult male mice were categorized into four groups: positive and negative control groups, one receiving a dopamine antagonist, and the other receiving both a dopamine antagonist and vitamins D and A. Sections of the corticobasal loop, specifically the motor cortex (M1) and basal nuclei (CPu), were prepared for Immunohistochemistry (IHC) and stained with Glial Fibrillary Acidic Protein (GFAP) to visualize active astrocytes. ELISA assays for TNF-α, IL-6, IL-4, IL-13, and dopamine levels were performed on homogenized brain sections.Results: The EPS group exhibited a significant increase in TNF-α and IL-6 levels in M1 and CPu. Treatment with dopamine agonists and vitamin D/A resulted in significant reductions in IL-6 levels. Only the Vitamin D/A group showed a significant decline in TNF-α. The EPS group recorded significant decreases in IL-4 and IL-13, with IL-13 significantly elevated in the dopamine agonist and Vitamin D/A groups. IL-4 was notably increased in the Vitamin D/A groups. Dopamine concentration significantly declined in the EPS group, with improvements observed in the groups treated with dopamine agonists, vitamin D, and A. Reactive astrocytes were significantly expressed in the M1 and CPu of the EPS group but poorly expressed in other regions.Conclusions: EPS is linked to astrocyte activation, an upsurge in pro-inflammatory cytokines, a decline in anti-inflammatory cytokines, and dopamine in the corticobasal loop. Administration of vitamin D3 and A was found to exert its effects by suppressing pro-inflammatory cytokines and repressing anti-inflammatory cytokines associated with astrocyte activation.

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Section: Discussionmentioning

confidence: 99%

Synergistic Action of Vitamin D3 and A Protects Motor Activity by Regulating Reactive Astrocytes, Inflammatory Cytokines, and Dopaminergic Activity in the Corticobasal Loop of a Mice Model of Extrapyramidal Syndrome

Sirajo,

Maigari,

Sunusi

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Synergistic action of vitamin D3 and A on motor activity regulation in mice model of extrapyramidal syndrome: Correlational insights into astrocyte regulation, cytokine modulation, and dopaminergic activity

Sirajo,

Maigari,

Sunusi

et al. 2024

Journal of Chemical Neuroanatomy

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The Effect of Chia Seed Extracts against Complete Freund’s Adjuvant-Induced Rheumatoid Arthritis in Rats

Aljumayi

Algarni

et al. 2022

Journal of Food Quality

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Background and Objectives. It is known that the oxidation of chia seeds is minimal or absent, due to the presence of bioactive compounds, having a great potential in the foods and pharmacological industry. This investigation was done to estimate the nutrition values and anti-oxidant activity of chia seed extracts. Materials and Methods. The protective effects of chia seed extract against complete Freund’s adjuvant (CFA) rheumatoid arthritis in rats were investigated with 100, 200, 300, and 400 ppm/kg BW rat/day chia seeds aqueous extract for 4 weeks. Results. The results obtained revealed that chia seed extract contained high proportions of protein and total dietary fiber values of 21.35% and 27.24%, respectively. Moreover, the results reported that the mineral contents were the greatest in phosphorous, potassium, magnesium, calcium, and sodium (450.09, 410.46, 245.22, 218.69, and 120.34 mg/100 g, respectively). Meanwhile, iron, zinc, and copper were the lowest in chia seeds (9.26, 4.67, and 3.66 mg/100 g, respectively). Besides, vitamins C and E reported 1.65 and 0.82 mg/100 g, respectively. Chia seed extracts were effective in vitro for the bioactive components such as phenolics, flavonoids, and anti-oxidant activities. The biomarkers of complete blood picture, lipid profile, anti-oxidant enzymes, TNF-α, and IL-10 had been improved. Histopathological examination of the rat knee confirmed health amelioration, revealing that chia seed extract consumption can lower pathological changes in injured rheumatoid arthritis rats. Conclusion. It could be seen that the chia seed extracts alleviated the harmful effect of rheumatoid arthritis CFA-induced rats.

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Tiroidektomize Ratlarda Serum IL-1β, IL-6, IL-10 ve TNF-α Seviyeleri

Cited by 5 publications

References 16 publications

Synergistic Action of Vitamin D3 and A Protects Motor Activity by Regulating Reactive Astrocytes, Inflammatory Cytokines, and Dopaminergic Activity in the Corticobasal Loop of a Mice Model of Extrapyramidal Syndrome

Synergistic Action of Vitamin D3 and A Protects Motor Activity by Regulating Reactive Astrocytes, Inflammatory Cytokines, and Dopaminergic Activity in the Corticobasal Loop of a Mice Model of Extrapyramidal Syndrome

Synergistic action of vitamin D3 and A on motor activity regulation in mice model of extrapyramidal syndrome: Correlational insights into astrocyte regulation, cytokine modulation, and dopaminergic activity

The Effect of Chia Seed Extracts against Complete Freund’s Adjuvant-Induced Rheumatoid Arthritis in Rats

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