Serum-Soluble Receptors for Tumor Necrosis Factor-α and Interleukin-2, and Neopterin in Acute Rheumatic Fever

Samsonov, Mikhail; Tilz, Gernot P.; Pisklakov, V.P.; Reibnegger, Gilbert; Nassonov, E L; Nassonova, V A; Wächter, Helmut; Fuchs, Dietmar

doi:10.1006/clin.1995.1005

Cited by 28 publications

(11 citation statements)

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“…We also performed ELISA assays for soluble IL-2 receptor (sIL-2R) in KD patients and controls as a marker of febrile response. 6–8 Levels of SIL-2R were comparable between KD patients (mean = 18.2 ng/ml) and febrile controls (mean = 15.33 ng/ml).…”

Section: Resultsmentioning

confidence: 81%

Periostin is Upregulated in Coronary Arteriopathy in Kawasaki Disease and is a Potential Diagnostic Biomarker

Reindel

Kim²,

Baker

et al. 2014

Pediatric Infectious Disease Journal

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Periostin was upregulated 11-fold in acute and chronic KD coronary arteries compared with controls (p=0.003). KD patients had significantly elevated serum periostin values compared with febrile controls (p=0.0086). There was no relationship between serum periostin values and age, gender, or acute phase reactants; there was a relationship between serum periostin and maximal coronary artery Z scores that did not reach significance (p=0.08). Periostin may prove to be useful as a component of a future diagnostic biomarker panel for KD.

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Section: Resultsmentioning

confidence: 81%

Periostin is Upregulated in Coronary Arteriopathy in Kawasaki Disease and is a Potential Diagnostic Biomarker

Reindel

Kim²,

Baker

et al. 2014

Pediatric Infectious Disease Journal

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“…In patients with myocarditis, n eopterin levels correlate highly significantly witll tlle course of disease, whereas stabilisation of tlle disease leads to a considerable decrease of neopterin conce ntrations unto the normal range. In patients with acute rheumatic fever (83) , the frequency of increased neopterin concentrations was found >80%. Still higher neopterin levels were found in patients developing a combined aortic and mitral insufficiency.…”

Section: Neopterin In Cardiovascular Diseasesmentioning

confidence: 94%

The Importance of Neopterin as a Laboratory Diagnostic Marker of Immune Activation

et al. 1999

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SummaryNeopterin is produced and secreted in large amounts by interferon-g stimulated human monocytes/ macrophages. Neopterin measurement in urine and semm provides a usefi.ll possibility to estimate the dcgree of ccllular (Thl-type) immune activation, which is directed against viral infections, intracellular bacteria, and certain parasites. Also in malignancy, autoimmw1e diseases and allograft rejection episodes neopterin sensitively reflects the extent of cellular immune activation. Determination of neoptcrin concentrations can be conveniently performed by immunoassay like ELISA or RIA, and HPLC. The major diagnostic applications of neopterin monitoring are: surveillancc of the immw1e status of organ recipients, therapy control and prognosis of diseasc progression in tumor diseascs and HIV infections and also detection of unknown infections in e.g. blood banks. High neopterin levels are strongly associated with oxidative stress, opening an additional application field of ncopterin monitoring to estimate the extent of tissue damagc in the course of immune activation.

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“…Tumor necrosis factor is one of the most important proinflammatory cytokines. In RF and RHD, increased plasma levels of TNF-a have been demonstrated [23][24][25]. TNF-a (also IL-1 and IL-2) production in the valvular lesions of RF patients was correlated with Aschoff nodule progression [26].…”

Section: Genetic Contribution To Susceptibilitymentioning

confidence: 97%

Understanding rheumatic fever

2011

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Through a comprehensive review of the recent findings on rheumatic fever, we intend to propose a new physiopathologic model for this disease. A Medline search was performed for all articles containing the terms rheumatic fever or rheumatic heart disease in title or abstract from 1970 to 2011. Best evidence qualitative technique was used to select the most relevant. The scientific interest on rheumatic fever has notably diminished throughout the twentieth century as evidenced by the comparison of the proportion of articles in which RF was a subject in 1950 (0.26%) and today (0.03%) [Pubmed]. However, RF remains a major medical and social problem in the developing world and in the so-called hotspots, where it still causes around 500.000 deaths each year, not too different from the pre-antibiotic era. The role of genetic factors in RF susceptibility is discussed. Familiar aggregation, similarity of disease patterns between siblings, identical twin, and HLA correlation studies are evidence for a genetic influence on RF susceptibility. The suspect-involved genes fall mainly into those capable of immunologic mediation. Molecular mimicry explains the triggering of RF, but an intense and sustained inflammation is needed to cause sequels. Also, RF patients vary greatly in terms of symptoms. It is likely that a genetic background directing immune response towards a predominantly Th1 or Th2 pattern contributes to these features. The recent findings on rheumatic fever provide important insight on its physiopathology that helps understanding this prototype post-infectious autoimmune disease giving insights on other autoimmune conditions.

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Serum-Soluble Receptors for Tumor Necrosis Factor-α and Interleukin-2, and Neopterin in Acute Rheumatic Fever

Cited by 28 publications

References 0 publications

Periostin is Upregulated in Coronary Arteriopathy in Kawasaki Disease and is a Potential Diagnostic Biomarker

Periostin is Upregulated in Coronary Arteriopathy in Kawasaki Disease and is a Potential Diagnostic Biomarker

The Importance of Neopterin as a Laboratory Diagnostic Marker of Immune Activation

Understanding rheumatic fever

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