Periostin is Upregulated in Coronary Arteriopathy in Kawasaki Disease and is a Potential Diagnostic Biomarker

Reindel, Rebecca; Kim, Kwang Youn; Baker, Susan C.; Shulman, Stanford T.; Perlman, Elizabeth J.; Lingen, Mark W.; Trevenen, Cynthia; Rowley, Anne H.

doi:10.1097/inf.0000000000000233

Cited by 9 publications

(7 citation statements)

References 14 publications

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“…PCR assays confirmed significant upregulation of CD74, CD69, IL18, HLA-F, NLRC5, and CD226, genes involved in antigen presentation and dendritic cell function, in KD CA tissues (Additional file 1 : Table S4). Genes that we previously identified as upregulated by real-time PCR on KD and control CA, including CD84, PIM2, POSTN, IL10RA, IL2RA, IQGAP2, and ITGA4 [ 26 – 28 ] were also identified as significantly upregulated by this transcriptome analysis, providing additional validation of our results.…”

Section: Resultssupporting

confidence: 82%

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The transcriptional profile of coronary arteritis in Kawasaki disease

et al. 2015

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BackgroundKawasaki Disease (KD) can cause potentially life-threatening coronary arteritis in young children, and has a likely infectious etiology. Transcriptome profiling is a powerful approach to investigate gene expression in diseased tissues. RNA sequencing of KD coronary arteries could elucidate the etiology and the host response, with the potential to improve KD diagnosis and/or treatment.MethodsDeep RNA sequencing was performed on KD (n = 8) and childhood control (n = 7) coronary artery tissues, revealing 1074 differentially expressed mRNAs. Non-human RNA sequences were subjected to a microbial discovery bioinformatics platform, and microbial sequences were analyzed by Metastats for association with KD.ResultsT lymphocyte activation, antigen presentation, immunoglobulin production, and type I interferon response were significantly upregulated in KD arteritis, while the tumor necrosis factor α pathway was not differentially expressed. Transcripts from known infectious agents were not specifically associated with KD coronary arteritis.ConclusionsThe immune transcriptional profile in KD coronary artery tissues has features of an antiviral immune response such as activated cytotoxic T lymphocyte and type I interferon-induced gene upregulation. These results provide new insights into the pathogenesis of KD arteritis that can guide selection of new immunomodulatory therapies for high-risk KD patients, and provide direction for future etiologic studies.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-015-2323-5) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 82%

“…The other 80 proteins are candidate diagnostic/prognostic biomarkers of KD arteritis; such biomarkers are urgently needed for diagnosis and monitoring of KD patients. We have previously reported one of the upregulated proteins, periostin, as a potential diagnostic biomarker of KD [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

The transcriptional profile of coronary arteritis in Kawasaki disease

et al. 2015

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“…This study also showed that periostin is significantly elevated in KD arteriopathy in both acute (within 2 months after onset) and chronic (5 months to years after onset) patients. 36 Plasma periostin along with periostin and Delta-like Notch ligand 1(DLL1) were higher in patients with severe dilated cardiomyopathy and showed positive correlation with degree of diastolic dysfunction.…”

Section: Clinical Studiesmentioning

confidence: 99%

Periostin as a novel biomarker of cardiovascular disease: A systematic evidence landscape of preclinical and clinical studies

Azharuddin

Adil

Ghosh

et al. 2019

J Evidence Based Medicine

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Background Periostin is a matricellular protein, expressed in various normal adult and fetal tissues. Recently, elevated periostin levels have been reported in heart failure, coronary artery disease, and stroke. However, there is lack of clinical studies to clarify the prognostic significance of systemic periostin levels in cardiovascular diseases (CVDs). The aim of the study was to perform a systematic review of published evidence on periostin and CVDs, and to clarify the diagnostic and prognostic significance of systemic periostin levels in CVDs. Methods A systematic search on PubMed was performed to identify relevant articles from inception to December 2018. The eligible studies evaluating the periostin expression and periostin levels in animal and human studies. Results A total of 24 relevant studies, including both animal and human data, were included. Periostin is significantly observed in myocardium tissue of failing hearts compared with control, and is also expressed in atherosclerotic plaques. Systemic periostin levels were significantly correlated with cardiac function and severity of CVD in several studies. A clinical study also observed positive correlation between periostin and N‐terminal pro b‐type natriuretic peptide (NT‐proBNP), highly sensitive troponin (hsTnT), and ST2 cardiac biomarker. Studies reported limited adjustment for potential confounders. Conclusions The evidence of current review support potential role of periostin in the pathophysiology of CVD. However, scarcity of data regarding the clinical use of periostin levels in the current management of CVDs further creates room for the future investigation. Therefore, further studies warrant to clarify its potential role, if any, as a novel cardiac biomarker.

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“…Periostin is a matricellular protein that mediates responses associated with cardiovascular injury. Reindel et al (44) have shown that periostin gets upregulated in coronary arteries during the acute and chronic phases of KD when compared to other febrile controls. Gamma-glutamyl transferase (GGT) and alanine transferase (ALT) have also been studied as biomarkers of cardiac inflammation.…”

Section: Proteomic Biomarkers (Table 3)mentioning

confidence: 99%

Biomarkers for Kawasaki Disease: Clinical Utility and the Challenges Ahead

et al. 2019

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Kawasaki disease (KD) has replaced acute rheumatic fever as the most common cause of acquired heart disease in children in the developed world and is increasingly being recognized from several developing countries. It is a systemic vasculitis with a predilection for coronary arteries. The diagnosis is based on a constellation of clinical findings that appear in a temporal sequence. Quite understandably, this can become a problem in situations wherein the clinical features are not typical. In such situations, it can be very difficult, if not impossible, to arrive at a diagnosis. Several biomarkers have been recognized in children with acute KD but none of these has reasonably high sensitivity and specificity in predicting the course of the illness. A line up of inflammatory, proteomic, gene expression and micro-RNA based biomarkers has been studied in association with KD. The commonly used inflammatory markers e.g. erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and total leucocyte counts (TLC) lack specificity for KD. Proteomic studies are based on the identification of specific proteins in serum, plasma and urine by gel electrophoresis. A host of genetic studies have identified genes associated with KD and some of these genes can predict the course and coronary outcomes in the affected individuals. Most of these tests are in the early stages of their development and some of these can predict the course, propensity to develop coronary artery sequelae, intravenous immunoglobulin (IVIg) resistance and the severity of the illness in a patient. Development of clinical criteria based on these tests will improve our diagnostic acumen and aid in early identification and prevention of cardiovascular complications.

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Periostin is Upregulated in Coronary Arteriopathy in Kawasaki Disease and is a Potential Diagnostic Biomarker

Cited by 9 publications

References 14 publications

The transcriptional profile of coronary arteritis in Kawasaki disease

The transcriptional profile of coronary arteritis in Kawasaki disease

Periostin as a novel biomarker of cardiovascular disease: A systematic evidence landscape of preclinical and clinical studies

Biomarkers for Kawasaki Disease: Clinical Utility and the Challenges Ahead

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