Serum Selenium Concentration in Liver Cirrhotic Patients Suffering from Hepatitis B and C in Pakistan

Ullah, Shafqat; Tahir, S.S.; Dilawar, Shahnaz; Ahmad, Irshad; Parvez, Shoukat

doi:10.1007/s12011-011-9182-y

Cited by 6 publications

(6 citation statements)

References 31 publications

(27 reference statements)

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“…Information on non-alcoholic liver disease [198], hepatitis B and C in Pakistan [199] and disease severity in cirrhotic patients [200] can be used as starting material for interested readers. …”

Section: Liver Degenerationmentioning

confidence: 99%

Blood selenium levels and factors influencing concentration values

Robberecht¹,

Cauwenbergh²,

Hermans³

2012

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Recent values for blood selenium concentrations in healthy persons in Belgium, Europe and worldwide are reviewed. ' Various factors, which probably influence the blood selenium concentration level of people residing in a given geographical area, are discussed. The literature is screened for the effects of age, gender, smoking and drinking habits, race, state of lactation, environmental exposure and medical treatment on eoncentration levels. The differences are mostly found to be small on the absolute scale, with only nutrition seeming to be a major factor. Selenium values in pathological conditions are not intensively discussed because it is not always well understood. Moreover, enhanced or decreased levels may be the cause or the consequence of the disease and hence do not give an indication of the etiology and physiopathological consequences of changes. The interested reader is only referred to some interesting and recent papers. Quite new in the interpretation of observed levels is gene polymorphism. This can be situated either in genes coding for seleniumdependent enzymes or other proteins. The first publications on selenium and the related field of nutrigenomies are included.

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Section: Liver Degenerationmentioning

confidence: 99%

Blood selenium levels and factors influencing concentration values

Robberecht¹,

Cauwenbergh²,

Hermans³

2012

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“…Liver cancer is a common type of gastrointestinal cancer, whose incidence is only second to that of stomach cancer (1).…”

Section: Introductionmentioning

confidence: 99%

“…In China, there are numerous patients with hepatitis, among whom hepatitis B is more common, and hepatitis B is often transferred into hepatitis B-cirrhosis-liver cancer (1). However, the clinical treatment of liver cancer is not ideal, which primarily results from the recurrence and metastasis of hepatocellular carcinoma (HCC) (1,2). Surgery remains the most effective treatment of liver cancer, but surgical resection is aimed only at the visible tumor, and it cannot remove the invisible small tumor foci or micro-metastases.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑543 suppresses liver cancer growth and induces apoptosis via the JAK2/STAT3 signaling pathway

Xiu

Wang

et al. 2018

Oncol Lett

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The aim of the present study was to investigate the function of microRNA-543 on liver cancer cell proliferation and apoptosis, and also to identify whether the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway was a direct target of microRNA-543. When compared with paracarcinoma tissue, microRNA-543 expression in tissue samples from patients with liver cancer was identified to be decreased. Furthermore, overall survival of patients with high microRNA-543 expression was increased compared with patients with low microRNA-543 expression. Inhibition of microRNA-543 expression increased cell proliferation and decreased apoptosis of liver cancer cells. It also activated the protein expression of phosphorylated JAK2, phosphorylated STAT3, c-Myc and B-cell lymphoma 2 (Bcl-2) in liver cancer cells. However, activation of microRNA-543 expression in turn decreased cell proliferation and increased apoptosis of liver cancer cells. The results of the present study highlight the pivotal function of microRNA-543 as an inhibitor in liver cancer cell proliferation by observing JAK2/STAT3/c-Myc/Bcl-2 in liver cancer.

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“…Pathogenesis of cataract and fibrocystic disease of the pancreas is related to deficiency of a number of elements, including selenium (Kumar et al, 2014). Also, deficiency of selenium is a cause of chronic hepatitis and rhematoid arthritis (Olesińska and Tuszkiewicz-Misztal, 2005;Khan et al, 2012;Rauf et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Endemic course of epidemic diarrhea of pigs in the stabilized focus of infection

Соболев

Gutyj

Grynevych

et al. 2017

Regul. Mech. Biosyst.

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Porcine epidemic diarrhea virus (PEDV) has been circulating in Ukraine since 2014 and induces an especially dangerous viral infection with a lethal diarrheal syndrome in newborn piglets, with the initial appearance at the focus of infection. The number of infected cases and lethality among diseased piglets of 1–5 days of age can reach 100%, which together with the forced anti-epizootic measures brings significant economic losses. PED can spread to all pigs, but the emergent quality of infectious pathology appears in newborn piglets. No effective and biologically safe means of specific antiviral prophylaxis, which substantially halts the epizootic process is registered, and etiopathogenetic therapy is not developed, therefore PED is an emergent infection which is difficult tocontrol. Over time there appear stationary foci of infection, where evolutionary changes in relationships in the host-parasite system take place fairly rapidly, since pigs are prolific and fast maturing animals able to replace each generation up to three times each year. This leads to a significant variability in interpopulation relationships and the induction of biodiversity in the molecular mechanisms of adaptation and processing of the viral genome. Clinically, genetic modifications of local variants of PEDV – populations are manifested in the form of changes in epizootic peculiarities in the course of infectious pathology in different age groups of animals. Modifications of PEDV may be accompanied by a slight weakening of the intensity of the infectious process, a decrease in mortality and a decrease in the severity of the pathogenesis of diarrheal syndrome. At the same time, the age range of severe abdominal lesions expands from newborn piglets to fattening animals of older age groups of 28, 32, 70 days. Using a set of measures to combat the PED, including “reverse feeding” recycled infected biomaterial from convalescent pigs, eradication of the pathogen from the environment of the host macroorganisms through a total disinfection regime and strict compliance with veterinary and sanitary rules of animal husbandry provide temporary positive results, but in theory this approach is incorrect, since contamination of animals leads to the dispersal of the virus and the formation of endemic foci of infection. The persistence of the virus in convalescent organisms is not fixed, the external inanimate environment can only be a mechanical factor in transmission of the pathogen preserving the viability of PEDV over time. Stabilization of the epizootic foci of infection is possible due to three factors: a) dissemination of the virus in “reverse feeding”; b) preservation of the virus in the external environment as a result of poor-quality disinfection; c) occurrence of a non-immune element among the convalescent young gilts, who as a result of juvenile insufficiency of the immune system have a low titer accumulation of colostral antibodies to the virus received in the biomaterial through reverse feeding. Due to the lack of “lactogenic immunity”, neonatal pigs as biological indicators for the presence of PEDV in the environment begin reproducing the virus in the enterocytes and develop a typical diarrheal syndrome PED.

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Serum Selenium Concentration in Liver Cirrhotic Patients Suffering from Hepatitis B and C in Pakistan

Cited by 6 publications

References 31 publications

Blood selenium levels and factors influencing concentration values

Blood selenium levels and factors influencing concentration values

MicroRNA‑543 suppresses liver cancer growth and induces apoptosis via the JAK2/STAT3 signaling pathway

Endemic course of epidemic diarrhea of pigs in the stabilized focus of infection

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