Serum resistin concentrations in children with Kawasaki disease

Nozue, Hiroki; Imai, Hironori; Saitoh, Hisako; Aoki, Takeshi; Ichikawa, Kunio; Kamoda, Tomohiro

doi:10.1007/s00011-010-0202-8

Cited by 14 publications

(14 citation statements)

References 42 publications

(45 reference statements)

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“…Therefore, it was reasonable to assume that serum resistin levels were significantly higher in KD patients than control subjects. Our finding of the increased levels of resistin from KD patients is in agreement with the previous research in Japanese patients with KD [33]. In a recent study, the results suggest that high serum resistin level may be a predictor of nonresponsiveness to intravenous immune globulin therapy [34].…”

Section: Discussionsupporting

confidence: 92%

Association of the Resistin Gene Promoter Region Polymorphism with Kawasaki Disease in Chinese Children

Liu

Gao

et al. 2012

Mediators of Inflammation

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Objectives. The −420 C > G polymorphism located in the resistin gene (RETN) promoter has recently been suggested to play a potential role in proinflammatory conditions and cardiovascular disease. This study investigated the association of the RETN promoter polymorphism with Kawasaki disease (KD) and its clinical parameters in Chinese children. Methods. We compared patients with complete KD to incomplete KD children. Genotyping of the RETN promoter polymorphism was performed using MassARRAY system, and serum resistin levels were estimated using the sandwich enzyme immunoassay method. Results. There was no significant difference in RETN (−420 C > G) genotypes between KD and control groups. However, the frequency of the G allele was higher in iKD patients than in cKD children due to a significantly increased frequency of the GG genotypes. Serum levels of resistin were significantly higher in KD patients than in controls regardless of the presence of coronary artery lesions (CALs). Conclusion. The present findings suggest that while resistin may play a role in the pathogenesis of KD, there is no apparent association between CAL and the RETN (−420 C > G) gene polymorphism in KD children. However, the diagnosis of iKD is challenging but can be supported by the presence of the G allele and the GG genotypes.

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Section: Discussionsupporting

confidence: 92%

Association of the Resistin Gene Promoter Region Polymorphism with Kawasaki Disease in Chinese Children

Liu

Gao

et al. 2012

Mediators of Inflammation

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“…Simultaneous inclusion of univariate predictors into a multivariate model resulted in a final parsimonious model with CRP in our study. In contrast, Nozue et al [17] showed that the only variable significantly associated with resistin concentrations before intravenous immune globulin therapy was body mass index. There were no obvious differences in the background characteristics of patients, including age, gender, weight, and CRP levels on admission, between their study and our present study.…”

Section: Discussionmentioning

confidence: 91%

“…However, there were no significant differences in serum levels of HMW adiponectin, leptin, and visfatin between the various patient groups. Nozue et al [17] recently reported that serum resistin levels in patients with Kawasaki disease were significantly higher than in healthy controls; however, they did not measure the levels of other adipokines. Human resistin is produced and released mainly in mononuclear cells (monocytes/macrophages) rather than adipocytes [18,19].…”

Section: Discussionmentioning

confidence: 98%

Serum adipokine profiles in Kawasaki disease

et al. 2011

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Adipokines are cytokines derived from adipose tissue. Recently it has been established that adipokines are closely linked to the pathophysiology of not only metabolic diseases, such as diabetes mellitus, obesity, and atherosclerosis, but also to inflammation and immune diseases. In this study we measured serum levels of adipokines in patients with acute Kawasaki disease to investigate the role of adipokines in the pathophysiology of Kawasaki disease. Serum resistin, high-molecular-weight (HMW) adiponectin, leptin, and visfatin levels were measured by enzyme-linked immunosorbent assay in a total of 117 subjects: 56 patients with acute Kawasaki disease, 30 healthy children, and 31 patients with acute infectious diseases. Serum resistin levels in patients with Kawasaki disease were significantly higher than those of healthy children and patients with acute infectious diseases. In contrast, mean serum HMW adiponectin, leptin, and visfatin levels in patients with Kawasaki disease exhibited no statistically significant differences compared with those in healthy children and patients with infectious diseases. Serum resistin levels decreased significantly after administration of intravenous immune globulin. Serum resistin levels on admission were significantly higher in nonresponders compared with responders to intravenous immune globulin therapy. A multivariate model revealed that C-reactive protein was a factor that was significantly related to elevated serum resistin level in patients with Kawasaki disease. In patients with Kawasaki disease, serum resistin levels were elevated, but decreased to nearly normal after intravenous administration of immune globulin. In contrast, serum HMW adiponectin, leptin, and visfatin levels showed no statistically significant changes. These findings suggest that resistin plays an important role, while other adipokines do not play a major role, in the pathogenesis of Kawasaki disease.

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“…The role of hypoadiponectinemia or hyperadiponectinemia on the degree of severity of KD remains controversial. Also, previous reports have shown that the serum resistin levels were elevated in KD children than healthy children, but its concentrations were unlikely to help predict the prognosis of disease in acute KD patients (4). There have been contrasting reports on the potential role of leptin in the pathogenesis of KD.…”

Section: Introductionmentioning

confidence: 99%

Association between Adipokines and Coronary Artery Lesions in Children with Kawasaki Disease

2014

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Body fat is an important source of adipokine, which is associated with energy balance and inflammatory and immune responses. However, the role of adipokines in coronary artery complications in Kawasaki disease (KD) has not yet been fully explained. We investigated whether serum adipokine level can be a useful marker for patients with KD who are at higher risk of developing coronary artery lesion (CAL). We measured adipokine levels and other inflammatory parameters in 40 patients with KD, 32 febrile controls, and 15 afebrile controls. Interleukin (IL)-6, tumor necrosis factor (TNF)-α and other laboratory parameters were also measured before and after intravenous immunoglobulin therapy, and in the convalescent phase. At admission, the serum resistin levels in KD children were significantly higher than those in controls (177.56 ng/mL in KD children, 76.48 ng/mL in febrile controls, and 17.95 ng/mL in afebrile controls). In patients with KD, resistin levels were significantly associated with decreased hemoglobin levels (P=0.049) and increased IL-6 levels (P=0.014). The serum IL-6 levels were significantly higher and body mass index was significantly lower in the group of KD with CALs than those without CALs (228.26 ng/mL vs. 39.18 ng/mL and 15.09 vs. 16.60, respectively). In conclusion, resistin is significantly elevated in KD patients, although it has no prognostic value of predicting coronary artery lesion in the acute stage.Graphical Abstract

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Serum resistin concentrations in children with Kawasaki disease

Abstract: We confirmed that resistin was an acute inflammatory protein, but its concentrations were unlikely to predict the prognosis of disease in acute KD patients.

Cited by 14 publications

References 42 publications

Association of the Resistin Gene Promoter Region Polymorphism with Kawasaki Disease in Chinese Children

Association of the Resistin Gene Promoter Region Polymorphism with Kawasaki Disease in Chinese Children

Serum adipokine profiles in Kawasaki disease

Association between Adipokines and Coronary Artery Lesions in Children with Kawasaki Disease

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