Serum adipokine profiles in Kawasaki disease

Abstract

Adipokines are cytokines derived from adipose tissue. Recently it has been established that adipokines are closely linked to the pathophysiology of not only metabolic diseases, such as diabetes mellitus, obesity, and atherosclerosis, but also to inflammation and immune diseases. In this study we measured serum levels of adipokines in patients with acute Kawasaki disease to investigate the role of adipokines in the pathophysiology of Kawasaki disease. Serum resistin, high-molecular-weight (HMW) adiponectin, leptin, and visfatin levels were measured by enzyme-linked immunosorbent assay in a total of 117 subjects: 56 patients with acute Kawasaki disease, 30 healthy children, and 31 patients with acute infectious diseases. Serum resistin levels in patients with Kawasaki disease were significantly higher than those of healthy children and patients with acute infectious diseases. In contrast, mean serum HMW adiponectin, leptin, and visfatin levels in patients with Kawasaki disease exhibited no statistically significant differences compared with those in healthy children and patients with infectious diseases. Serum resistin levels decreased significantly after administration of intravenous immune globulin. Serum resistin levels on admission were significantly higher in nonresponders compared with responders to intravenous immune globulin therapy. A multivariate model revealed that C-reactive protein was a factor that was significantly related to elevated serum resistin level in patients with Kawasaki disease. In patients with Kawasaki disease, serum resistin levels were elevated, but decreased to nearly normal after intravenous administration of immune globulin. In contrast, serum HMW adiponectin, leptin, and visfatin levels showed no statistically significant changes. These findings suggest that resistin plays an important role, while other adipokines do not play a major role, in the pathogenesis of Kawasaki disease.

Association of the Resistin Gene Promoter Region Polymorphism with Kawasaki Disease in Chinese Children

“…Our finding of the increased levels of resistin from KD patients is in agreement with the previous research in Japanese patients with KD [33]. In a recent study, the results suggest that high serum resistin level may be a predictor of nonresponsiveness to intravenous immune globulin therapy [34]. However, there were no obvious differences in the genomic frequencies and genotype between responders and nonresponders Therefore, more studies are needed to confirm the hypothesis that the association between resistin concentration and the nonresponders.…”

Association of Serum Adiponectin, Leptin, and Resistin Concentrations with the Severity of Liver Dysfunction and the Disease Complications in Alcoholic Liver Disease

“…Yoshino et al [57] reported that the plasma levels of resistin and leptin positively correlated with the CRP level in patients with rheumatoid arthritis. Similar observations in patients with Kawasaki disease come from Kemmotsu et al report [67]. The level of CRP was significantly associated with an increased level of resistin in that study.…”

High Prevalence of Metabolic Syndrome in Takayasu Arteritis: Increased Cardiovascular Risk and Lower Adiponectin Serum Levels

“…In fact, studies conducted in other forms of vasculitis, such as Kawasaki disease 35 and Behçet disease 36 , showed higher resistin levels than healthy controls but no differences in adiponectin levels. In fact, studies conducted in other forms of vasculitis, such as Kawasaki disease 35 and Behçet disease 36 , showed higher resistin levels than healthy controls but no differences in adiponectin levels.…”