Association of the Resistin Gene Promoter Region Polymorphism with Kawasaki Disease in Chinese Children

Abstract

Objectives. The −420 C > G polymorphism located in the resistin gene (RETN) promoter has recently been suggested to play a potential role in proinflammatory conditions and cardiovascular disease. This study investigated the association of the RETN promoter polymorphism with Kawasaki disease (KD) and its clinical parameters in Chinese children. Methods. We compared patients with complete KD to incomplete KD children. Genotyping of the RETN promoter polymorphism was performed using MassARRAY system, and serum resistin levels were estimated using the sandwich enzyme immunoassay method. Results. There was no significant difference in RETN (−420 C > G) genotypes between KD and control groups. However, the frequency of the G allele was higher in iKD patients than in cKD children due to a significantly increased frequency of the GG genotypes. Serum levels of resistin were significantly higher in KD patients than in controls regardless of the presence of coronary artery lesions (CALs). Conclusion. The present findings suggest that while resistin may play a role in the pathogenesis of KD, there is no apparent association between CAL and the RETN (−420 C > G) gene polymorphism in KD children. However, the diagnosis of iKD is challenging but can be supported by the presence of the G allele and the GG genotypes.

Serum Levels of Syndecan-1 in Patients With Kawasaki Disease

“…An early study reported that increased serum MMP-9 levels in patients with CALs were higher than those without CALs. 3,21,22 Lau et al 25 has demonstrated that inhibition of MMP-9 activity improves coronary outcome in an animal model of KD affirming that MMP-9 is crucial for the development of CALs in KD patients. 26,27 Yang et al 29 showed that MMP-9 plays a crucial role in the shed ectodomain of SDC-1 in vivo.…”

“…KD is a systemic vasculitis with increased IL-1β, IL-6, TNF-α, MMP-9, soluble cell adhesion molecules-1 (sICAM-1) and resistin. 3,21,22 It is unknown whether SDC-1 plays an important role in KD and if SDC-1 serum levels could be used as a biomarker to predict the development of CALs in patients during the acute phase. In this study, we aimed to ascertain the serum levels of SDC-1 in the acute phase of KD and elucidate whether there is a connection between serum levels of SDC-1 and CALs.…”

Effects of Leptin, Resistin, and <i>PPAR</i>-Gama Gene Variants on Obese Patients with Acute Coronary Syndrome in the Turkish Population

“…One of the most frequently studied polymorphisms, C to G substitution at -420 position in the 5' flanking region of the gene showed altered resistin gene expression (mRNA levels) in abdominal fat with increased serum resistin level (35). This polymorphism has independently been associated with cardiovascular risk factors, such as insulin resistance, type 2 diabetes mellitus (T2DM), obesity, hypertension, dyslipidemia, and metabolic syndrome, as well as with coronary heart disease (arteriosclerosis, coronary artery disease, idiopathic dilated cardiomyopathy) (36)(37)(38)(39). In a meta-analysis, G allele of Resistin-420 C/G polymorphism was reported as a risk factor for obesity (40).…”

Association between miRNA‐196a2 rs11614913 T>C polymorphism and Kawasaki disease susceptibility in southern Chinese children

“…In Asian populations only, numerous polymorphic genes have been reported, including VEGF , COL11A2 in a Taiwanese population, and FAM167A‐BLK , HLA‐DQB2‐HLA‐DOB , and CD40 in a Japanese population . In addition, IL‐10 , ITPKC , RETN , and TNFR1 were reported in a Chinese population . However, studies on the association of miRNA polymorphisms with Kawasaki disease are rare.…”