Serum proteins in prostatic cancer II. effect on in vitro cell-mediated immunologic responsiveness

Ablin, Richard J.; Guinan, Patrick; Bruns, Gailon R.; Sadoughi, Nader; Bush, Irving M.

doi:10.1016/0090-4295(75)90586-5

Cited by 10 publications

(7 citation statements)

References 23 publications

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Section: Discussionsupporting

confidence: 78%

“…Observation of aberrations of lymphocytic reactivity prior to treat ment in patients with prostatic cancer provides confirmation to previous studies in this [18,20,23] and other laboratories. In the present study, as in previous [18,20,23], no correlation between the degree of responsive ness to PHA and the patients' clinical stage of malignancy was observed. However, of real and relevant concern were observations of a further re duction in the patients' lymphocytic responsiveness following each of the three treatment modalities evaluated, i.e., in 10 of 11 (91%) following re ceipt of oestrogen, and in 3 of 3 (100%) and 9 of 10 (90%) of the patients following cryosurgery and TUR, respectively.…”

Section: Discussionsupporting

confidence: 78%

“…[34], and reports from this [20] and other laboratories of suppression of lymphocytes cultured in serum with an elevated level of «¡.-globulin, brief mention of the possible relationship of the level of a2 quantitated prior to and following each of the treatment modalities employed to the response of PHA-stimulated PBL cultured in autologous serum observed in this study, would seem appropriate.…”

Section: Discussionmentioning

confidence: 99%

“…As studies in this [20] and other laboratories have described inhibition of the transformation of PHA-stimulated PBL cultured in serum with an elevated level of a2-gIobulin, the level of a2-globulin was determined, when possible, in serum speci mens by cellulose acetate electrophoresis followed by densitometric quantitation [21]. Total serum protein was measured by the biuret method [22].…”

Section: Serum Protein Electrophoresismentioning

confidence: 99%

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Evaluation of Cellular Immunologic Responsiveness in the Clinical Management of Patients with Prostatic Cancer

Rj¹,

Pd²,

Gr³

et al. 1976

Urol Int

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The effect of oestrogen, cryosurgery and transurethral resection (TUR) of the prostate on the blastogenic response of thymic-dependent peripheral blood lymphocytes (PBL) to the non-specific mitogen, phytohaemagglutinin (PHA) was evaluated as one in vitro criteria of each of these treatment modalities on the cellular immunologic responsiveness of 24 patients with prostatic cancer. A depression 5 days following receipt of oestrogen and 2–7 days following cryosurgery or TUR of the responsiveness of PHA-stimulated PBL was observed. Oestrogen-induced aberrations of responsiveness may not only be of relevance in prostatic cancer patients, but also to the suggested association between uterine cancer and prolonged administration of diethylstilboesterol and the development of vaginal tumours in offspring found in association with maternal ingestion during pregnancy. Particularly striking was that contrary to the reduced responsiveness of PBL cultured in autologous and homologous serum from patients receiving TUR, patients receiving cryosurgery, while also showing reduction in autologous serum, showed increased responsiveness when cultured in homologous serum. Although transient, depression of lymphocyte responsiveness, particularly if involving tumour-cloned T cells, may provide reduced surveillance to potential metastatic tumour cells leading to an alteration of tumour-host homeostasis. The potential of reduced tumour surveillance at least in the case of TUR, appears to be supported by observations that patients expiring from prostatic cancer at our institution had an antecedent TUR. The possibility of identifying those patients possessing aberrations of responsiveness prior to therapy, as well as those prone to develop or undergo further reductions in their responsiveness following the presently evaluated treatment modalities would appear to be of real and relevant concern in the management of the patient with prostatic, as well as other types of malignant neoplasms. The possibility of pre-operative and/or post-operative immunotherapy in such patients may be indicated pending further study.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Serum Protein Electrophoresismentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of Cellular Immunologic Responsiveness in the Clinical Management of Patients with Prostatic Cancer

Rj¹,

Pd²,

Gr³

et al. 1976

Urol Int

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“…migration are suppressed by such sera from patients with prostatic cancer prior to (9) but not at all or to the same degree following cryotherapy (1 b).…”

mentioning

confidence: 99%

Alterations of α<sub>2</sub> -Globulin and the Clinical Response in Patients with Prostatic Cancer following Cryotherapy

Ablin¹,

Gonder²,

Soanes³

1975

Oncology

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Evaluation of alterations in the level of α₂-globulin in the serum of 18 patients with prostatic cancer prior to and following cryotherapy of their primary prostatic tumor and the clinical response of these patients disclosed: (1) a progressive increase in the level of α₂ -globulin and the incidence of patients with significantly elevated levels of α₂-globulin, i.e., > 1.30 g/l00 ml, with a progression of the stage of their malignancy; (2) a decrease in the levels of α₂ -globulin in the serum of 14 of 18 (78 %) patients following cryotherapy, and (3) a favorable clinical response in 11 of 14 (79 %) patients with prostatic cancer showing a decrease in α₂ -globulin following cryotherapy. While limited to the study of a relatively small patient population, the present results suggest a prognostic potential for α₂ -globulin, particularly as applied to stage identification in prostatic cancer. Pending confirmation by evaluation of a larger patient population, it may even provide objective criteria for monitoring the clinical response of an individual following cryotherapy of the prostate.

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Immunologic Phenomena Induced by Cryosurgery

Ablin

Guinan

1979

Immunodiagnosis and Immunotherapy of Malignant Tumors

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Serum proteins in prostatic cancer II. effect on in vitro cell-mediated immunologic responsiveness

Cited by 10 publications

References 23 publications

Evaluation of Cellular Immunologic Responsiveness in the Clinical Management of Patients with Prostatic Cancer

Evaluation of Cellular Immunologic Responsiveness in the Clinical Management of Patients with Prostatic Cancer

Alterations of α<sub>2</sub> -Globulin and the Clinical Response in Patients with Prostatic Cancer following Cryotherapy

Immunologic Phenomena Induced by Cryosurgery

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