1976
DOI: 10.1159/000280075
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Evaluation of Cellular Immunologic Responsiveness in the Clinical Management of Patients with Prostatic Cancer

Abstract: The effect of oestrogen, cryosurgery and transurethral resection (TUR) of the prostate on the blastogenic response of thymic-dependent peripheral blood lymphocytes (PBL) to the non-specific mitogen, phytohaemagglutinin (PHA) was evaluated as one in vitro criteria of each of these treatment modalities on the cellular immunologic responsiveness of 24 patients with prostatic cancer. A depression 5 days following receipt of oestrogen and 2–7 days following cryosurgery or TUR of the responsiveness of PHA-stimulated… Show more

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Cited by 14 publications
(15 citation statements)
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“…Thus, in an attempt to evaluate the presence of host responsiveness to tumour in patients with prostatic can cer, the applicability of the method of direct migration inhibition of leuco cytes from prostatic cancer patients to pooled allogeneic extracts of nor mal, benign and malignant prostatic tissue has been investigated. With ex ception of preliminary communications from this laboratory employing inhibition of leucocyte migration (1LM) [4,5] and of the use of antigeninduced leucocyte adherence inhibition [6][7][8], there are few, if any, stud ies of in vitro cellular immunity to prostatic tissue.…”
Section: ]-mentioning
confidence: 99%
See 1 more Smart Citation
“…Thus, in an attempt to evaluate the presence of host responsiveness to tumour in patients with prostatic can cer, the applicability of the method of direct migration inhibition of leuco cytes from prostatic cancer patients to pooled allogeneic extracts of nor mal, benign and malignant prostatic tissue has been investigated. With ex ception of preliminary communications from this laboratory employing inhibition of leucocyte migration (1LM) [4,5] and of the use of antigeninduced leucocyte adherence inhibition [6][7][8], there are few, if any, stud ies of in vitro cellular immunity to prostatic tissue.…”
Section: ]-mentioning
confidence: 99%
“…These investigations have evaluated lymphocytic blastogenesis to PHA in prostatic cancer patients prior to [ 1 ] and followine therapy [ …”
Section: Introductionmentioning
confidence: 99%
“…Although, other explanations for clinical evidence suggestive of an immunologic response to a prostatic tumor-specific or TAA following cryoprostatectomy are tenable, the subsequent failure to identify tumor-specific or TAA would be somewhat surprising. In this regard, preliminary studies demonstrating a differential response between leukocytes from patients with prostatic cancer to extract preparations o f allogeneic and autologous pros tatic tissue and normal prostatic tissue as evaluated by inhibition o f leukocyte migration (39,40) and the presence of cytotoxic lymphocytes in patients with prostatic cancer (41) are suggestive o f cellular sensitivity to malignant tissue antigens.…”
Section: Parenteral Immunizationmentioning
confidence: 99%
“…Here, the elaboration of leukocyte inhibitory factor from lymphocytes sensitized in situ to malignant prostatic tissue as evaluated by the inhibition of leukocytes from patients with prostatic cancer in the presence o f allogeneic or autologous prostatic tissue (39,40) and recent evidence o f the presence o f cytotoxic 'killer' lymphocytes in patients with prostatic cancer (41 ) may offer added credence to this approach.…”
Section: Lymphocytesmentioning
confidence: 99%
“…Leukocyte migration was carried out by a modification of the method of Bendixen and So boro [10] as recently detailed [11]. In brief, leukocytes were resuspended to a final con centration of 70 x 106 cells/ml.…”
Section: Leukocyte Migrationmentioning
confidence: 99%