Migration-Inhibitory Effect of Serum from Patients with Prostatic Cancer

Ablin, Richard J.; Bruns, Gailon R.; Guinan, Patrick; Bush, Irving M.

doi:10.1159/000224982

Cited by 8 publications

(1 citation statement)

References 11 publications

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“…Lymphocyte migration was carried out by modification of the microtechnique of the method of Bendixe and S<j>borg (16) described by Federlin et al (17) employing allogeneic leucocytes from healthy adult males as recently detailed (18).…”

Section: Methodsmentioning

confidence: 99%

Serum Proteins in Prostatic Cancer

Ablin

1977

Urol Int

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Preliminary studies of sera from prostatic cancer patients have indicated a reduction in the presence of suppressive (‘blocking’?) properties of in vitro parameters of cell-mediated immunologic responsiveness induced by a non-specific mitogen (phytohaemagglutinin) in association with a decrease in the level of α₂-globulin and favourable clinical response following cryosurgery. The origin of the immunosuppressive factor(s) migrating on electrophoresis in the α₂-globulin fraction of serum remains to be identified. Earlier demonstration of suppression of leucocyte migration by factors elaborated from tumour cells and recent observations of the suppression of lymphocytic reactivity by seminal plasma and coaguloprostatic fluid suggest that suppression and reduction or abrogation of the suppressive properties of serum following cryosurgical destruction of tumour may be attributed to a reduction in soluble prostatic tumour-associated antigen shed into the circlation by previously viable tumour. Such antigen while not at a sufficient concentration to engender an immunologic response in the aging and tumour-burdened host, may, however, have been sufficient to pre-empt the effector limb of cell-mediated responsiveness contributing to the observed suppression of lymphocytic reactivity. Cryosurgery, resulting in necrosis and cell death with depletion of the primary source of antigen might thereby have permitted a previously overwhelmed host to respond, viz., the favourable clinical response observed.

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Section: Methodsmentioning

confidence: 99%

Serum Proteins in Prostatic Cancer

Ablin

1977

Urol Int

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Plasma transferable inhibition of BCG induced subcutaneous inflammation in human cancer

Bureau¹,

Senelar²,

Cupissol³

1981

The Journal of Pathology

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When a small dacron sponge disc containing live BCG was implanted subcutaneously in healthy subjects it became infiltrated with leukocytes which at 24 hours mainly involved neutrophils. this mycobacterial-induced inflammatory response was markedly impaired in patients with cancer. This inhibitory effect could be reproduced by injecting the plasma of these patients into guinea-pigs bearing identical discs. The differences in inflammatory reactions in the indirect technique were less marked than in the direct test, though a parallelism between the two was seen. The fact that the plasma from cancer patients interferes with neutrophil responses in this way does not exclude the possibility that abnormal cellular functions were also operative. Since tumour growth control depends on effective inflammation these data further underline the importance in cancer patients of a defect at this level.

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Immunologic Phenomena Induced by Cryosurgery

Ablin

Guinan

1979

Immunodiagnosis and Immunotherapy of Malignant Tumors

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Migration-Inhibitory Effect of Serum from Patients with Prostatic Cancer

Cited by 8 publications

References 11 publications

Serum Proteins in Prostatic Cancer

Serum Proteins in Prostatic Cancer

Plasma transferable inhibition of BCG induced subcutaneous inflammation in human cancer

Immunologic Phenomena Induced by Cryosurgery

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