Serum paraoxonase activity is associated with epicardial fat tissue in renal transplant recipients

Koçyiğit, İsmail; Ünal, Aydın; Korkar, Hafsa; Karakükçü, Çiğdem; Örsçelik, Özcan; Sipahioğlu, Murat Hayri; Tokgöz, Bülent; Oymak, Oktay

doi:10.1007/s11255-015-1051-8

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…In a post hoc analysis on 98 kidney transplant patients, the impact of the epicardial fat gain on ventricular mass after kidney transplantation could not be positively confirmed [59]. Similar to hemodialysis patients, PON-1 activity was found to be inversely correlated with EAT thickness in renal transplant patients [60]. When EAT changes were compared between hemodialysis patients and kidney transplant patients, EAT measurements were significantly higher in hemodialysis patients than in the kidney transplant patients, and the EAT measurements of the kidney transplant patients were not statistically different from the healthy subjects [61].…”

Section: Eat In Renal Transplantationmentioning

confidence: 99%

Epicardial Adipose Tissue and Renal Disease

Aeddula

Cheungpasitporn

Pathireddy

2019

JCM

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Epicardial adipose tissue (EAT) is derived from splanchnic mesoderm, localized anatomically between the myocardium and pericardial visceral layer, and surrounds the coronary arteries. Being a metabolically active organ, EAT secretes numerous cytokines, which moderate cardiovascular morphology and function. Through its paracrine and vasocrine secretions, EAT may play a prominent role in modulating cardiac function. EAT protects the heart in normal physiological conditions by secreting a variety of adipokines with anti-atherosclerotic properties, and in contrast, secretes inflammatory molecules in pathologic conditions that may play a dynamic role in the pathogenesis of cardiovascular diseases by promoting atherosclerosis. Considerable research has been focused on comparing the anatomical and biochemical features of EAT in healthy people, and a variety of disease conditions such as cardiovascular diseases and renal diseases. The global cardiovascular morbidity and mortality in renal disease are high, and there is a paucity of concrete evidence and societal guidelines to detect early cardiovascular disease (CVD) in this group of patients. Here we performed a clinical review on the existing evidence and knowledge on EAT in patients with renal disease, to evaluate its application as a reliable, early, noninvasive biomarker and indicator for CVD, and to assess its significance in cardiovascular risk stratification.

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Section: Eat In Renal Transplantationmentioning

confidence: 99%

Epicardial Adipose Tissue and Renal Disease

Aeddula

Cheungpasitporn

Pathireddy

2019

JCM

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Assessment of the relationship between serum paraoxonase activity and epicardial adipose tissue in hemodialysis patients

et al. 2016

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Evaluation of lipid metabolizing enzymes: Paraxonase1 (PON1) and lecithin cholesterol acyltransferase (LCAT) activities in children with nephrotic syndrome

Ali

Baban

Ali

2021

Baghdad J. Biochem. Appl. Biol. Sci.

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Background: The most common glomerular disorder in children is nephrotic syndrome, associated with high morbidity despite notable advances in its treatment. Many of the nephrotic syndrome complications, including the increased risk of atherosclerosis and thromboembolism, can be linked to dysregulated lipid metabolism and dyslipidemia. Paraoxonase enzyme is responsible for the most of antioxidant properties of HDL, thus preventing the formation of atherogenic ox-LDL molecules, and Lecithin Cholesterol acyltransferase is intimately involved in HDL maturation and is a key component of the reverse cholesterol transport pathway, which removes excess cholesterol molecules from the peripheral tissues to the liver for excretion. Objective: The present study aimed to investigate the serum activities of paraoxonase-1(PON-1) and lecithin cholesterol acyltransferase (LCAT) in children with nephrotic syndrome in an active phase (as newly diagnosed or old cases with acute relapse) also, to study any correlation exists between paraoxonase-1 activity and lipid profile. Methods: This study consists of Group 1 with 40 cases of nephrotic syndrome in the age group of (2-14 years) and Group 2 with 40 age and sex-matched healthy controls. Lipid profile and paraoxonase activity, Lecithin Cholesterol acyltransferase activities were measured in both groups' serum samples. Results: Statistical analysis by student's t-test showed that the mean levels of Total Cholesterol, Triglycerides, LDL were significantly increased in Group 1 when compared to Group 2 (p <0.001). PON1 and Lecithin Cholesterol acyltransferase levels were significantly lowered in Group 1 compared to Group 2, and there is no significant difference among nephrotic groups. Conclusion: Both Paraoxonase-1 enzyme and Lecithin Cholesterol acyltransferase are considered good promising predictors for nephrotic syndrome and other parameters such as LDL, HDL, and T.G. The significantly decreased Paraoxonase-1 enzyme and Lecithin Cholesterol acyltransferase activities result in increased oxidation of LDL, thus accelerating atherosclerosis.

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Serum paraoxonase activity is associated with epicardial fat tissue in renal transplant recipients

Abstract: Reduced PON-1 activity was negatively associated with EFT and PON-1 activity independently predicts EFT in renal transplant recipients.

Cited by 3 publications

References 37 publications

Epicardial Adipose Tissue and Renal Disease

Epicardial Adipose Tissue and Renal Disease

Assessment of the relationship between serum paraoxonase activity and epicardial adipose tissue in hemodialysis patients

Evaluation of lipid metabolizing enzymes: Paraxonase1 (PON1) and lecithin cholesterol acyltransferase (LCAT) activities in children with nephrotic syndrome

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