Assessment of the relationship between serum paraoxonase activity and epicardial adipose tissue in hemodialysis patients

Abdallah, Emad; El-Shishtawy, Samya; Sherif, Nevine; Ahmed, Ali; El-Bendary, Omnia

doi:10.1007/s11255-016-1465-y

Cited by 12 publications

(23 citation statements)

References 33 publications

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“…In a cross-sectional study of 72 hemodialysis patients, a low HDL cholesterol level was identified as an independent risk factor of elevated EAT thickness. 19 A meta-analysis showed that there was a highly significant (p < 0.001) correlation between EAT thickness and HDL cholesterol. 5 Our results confirm the previous findings.…”

Section: Discussionmentioning

confidence: 99%

A new measurement site for echocardiographic epicardial adipose tissue thickness and its value in predicting metabolic syndrome

et al. 2019

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A new measurement site for echocardiographic epicardial adipose tissue thickness and its value in predicting metabolic syndrome. AbstractBackground. Echocardiographic epicardial adipose tissue (EAT) thickness is defined as the thickness of the low-isoechoic area on the free wall of the right ventricle in the parasternal long-axis and short-axis views. Recent studies have suggested that it might support current risk stratification strategies in identifying an increased risk of metabolic syndrome.Objectives. The aim of this study is to explore a new measurement site which can better reflect EAT thickness and to assess its value in predicting metabolic syndrome. Material and methods.A total of 975 Chinese adults were measured for EAT thickness on the right ventricular anterior free wall (EAT-rv) and on the anterior interventricular groove (EAT-ivg) with echocardiography. The correlation between EAT thickness and metabolic syndrome was analyzed, as was the agreement between epicardial adipose volume (EAV) and EAT thickness. Independent risk factors of EAT thickness were identified and the predictive value of EAT thickness was assessed.Results. Epicardial adipose tissue thickness was higher in older participants and those with obesity, diabetes, hypertension, hypertriglyceridemia, and metabolic syndrome, and it was lower in male participants. The EAT-ivg was higher in the participants with hypo-high-density-lipoprotein cholesterolemia than in those without the disorder, but the EAT-rv values were not statistically different. The kappa value was 0.524 between EAT-rv and EAV, and 0.783 between EAT-ivg and EAV. Advanced age, large waist circumference and female gender were independent risk factors of high EAT-ivg, while high-density-lipoprotein (HDL) cholesterol was a protective factor. The EAT-ivg was associated with metabolic syndrome. The area under the curve of EAT-ivg applied in predicting metabolic syndrome was greater than that of EAT-rv (0.715 vs 0.648). Conclusions.The EAT-ivg was more consistent with EAV than EAT-rv, was independently associated with metabolic syndrome and had a higher value in predicting metabolic syndrome than EAT-rv. Therefore, the anterior interventricular groove can serve as a new measurement site which better reflects EAT thickness.

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Section: Discussionmentioning

confidence: 99%

A new measurement site for echocardiographic epicardial adipose tissue thickness and its value in predicting metabolic syndrome

et al. 2019

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“…Oxidative stress is another mechanism responsible for increased risk other than infiltration. Previous studies have shown a positive correlation between EFT and serum oxidant content and a negative correlation with anti oxidant content (16)(17).…”

Section: Discussionmentioning

confidence: 84%

Evaluation of Epicardial Fat and Carotid and Femoral Intima-Media Thicknesses in Geriatric Patients With End-Stage Renal Disease

Güneşli¹,

Yılmaz²,

Yalçin³

et al. 2020

tjgeri

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Although atherosclerotic cardiovascular diseases and cardiovascular risks are known to increase in patients with end-stage renal disease, it is not clear whether these risks increase in the geriatric patient population as well. This study aims to evaluate these risks in geriatric patients with end-stage renal disease by evaluating epicardial fat and carotid and femoral intima-media thicknesses, known as markers, for subclinical atherosclerosis and cardiovascular risks. Materials and Methods: This cross-sectional study included 52 patients who started to receive chronic hemodialysis treatment after the age of 65 years (mean age 73.92±5.63) years with end-stage renal failure and 51 healthy volunteers (mean age: 74.49±4.63 years). Epicardial fat and carotid and femoral intima-media thicknesses were measured and compared between these groups. Results: Carotid intima-media and epicardial fat thicknesses were significantly higher in the patient group than in the control group (0.91±0.08 vs. 0.71±0.1 mm, p<0.001 and 0.84±0.17 vs. 0.75±0.17 cm, p=0.01, respectively). However, no significant difference was observed in femoral intima-media thickness between the two groups (0.58±0.07 vs. 0.56±0.97 mm, p=0.266). Correlation analysis revealed a significant positive correlation between the duration of dialysis and epicardial fat and carotid intima-media thicknesses (r=0.611, p<0.001 and r=0.337, p=0.015, respectively). Furthermore, regression analysis revealed a significant relationship between the duration of dialysis and carotid intima-media thickness (β=0.657, p=0.001). Conclusion: Epicardial fat and carotid intima-media thicknesses increase in geriatric patients with end-stage renal disease but with no significant changes in femoral intima-media thickness, indirectly suggesting that subclinical atherosclerosis and cardiovascular risks are increased in these patients.

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“…However, a few females in the grade 3 with very low PON1 levels and males in the grade 1 with high PON1 levels suggested that differences in serum PON1 levels might be, not only gender-dependent, but also dependent of a certain genetic factor(s). Certain polymorphic variants of human PON1 showed high enzyme activities and a positive association with the fatty acid composition in the body [8,9]. The positive association of serum PON1 levels with meat quality implicates the PON1 polymorphism that needs to be investigated for the genetic improvement of Hanwoo.…”

Section: Resultsmentioning

confidence: 99%

“…Polymorphic variants of human PON1 were reported to be significantly different in the enzyme activity of PON1 showing a positive association with the fatty acid composition of the adipose tissue [8]. Another study demonstrated an inverse correlation of PON1 activity with the thickness of epicardial adipose tissue, which suggested a possible role of PON1 in the regulation of the lipid composition in body [9].…”

Section: Introductionmentioning

confidence: 99%

Gender-dependent difference in serum paraoxonase 1 levels of Hanwoo, Korean native cattle, and a positive association with meat quality

Park

Kim

Hwang

et al. 2019

Asian-Australas J Anim Sci

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Assessment of the relationship between serum paraoxonase activity and epicardial adipose tissue in hemodialysis patients

Abstract: Our study demonstrated that PON-1 activity was significantly lower in HD patients compared with healthy controls and that PON-1 activity was inversely correlated with EATT in this population.

Cited by 12 publications

References 33 publications

A new measurement site for echocardiographic epicardial adipose tissue thickness and its value in predicting metabolic syndrome

A new measurement site for echocardiographic epicardial adipose tissue thickness and its value in predicting metabolic syndrome

Evaluation of Epicardial Fat and Carotid and Femoral Intima-Media Thicknesses in Geriatric Patients With End-Stage Renal Disease

Gender-dependent difference in serum paraoxonase 1 levels of Hanwoo, Korean native cattle, and a positive association with meat quality

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