Serum neutrophil gelatinase-associated lipocalin as a marker of acute kidney injury in asphyxiated neonates

Raggal, Nm El; Khafagy, Soha M.; Mahmoud, Nermin H.; Beltagy, Sa El

doi:10.1007/s13312-013-0153-6

Cited by 24 publications

(25 citation statements)

References 14 publications

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“…High initial serum NGAL level was signifi cantly associated with the subsequent diagnosis of AKI in these neonates. It was thus speculated by that author that early measurement of this biomarker in asphyxiated neonates can reliably predict the development of postasphyxial acute kidney injury 13 . As mentioned earlier, we had only four babies who developed AKI.…”

Section: Resultsmentioning

confidence: 99%

Clinical Utility of Serum Neutrophil Gelatinase Associated Lipocalin(NGAL) as an Early Marker of Acute Kidney Injury in Asphyxiated Neonates

Chandrashekar

Venkatkrishnan

2016

J. Nepal Paedtr. Soc.

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Section: Resultsmentioning

confidence: 99%

Clinical Utility of Serum Neutrophil Gelatinase Associated Lipocalin(NGAL) as an Early Marker of Acute Kidney Injury in Asphyxiated Neonates

Chandrashekar

Venkatkrishnan

2016

J. Nepal Paedtr. Soc.

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“…However, collecting urine for AKI evaluation is difficult owing to anuria, oliguria, or impaired urine-concentration ability in infants 8) . Considering that urinary NGAL levels are correlated with the plasma or serum levels of NGAL regardless of the cause of increased NGAL production 27) , many studies have evaluated the value of blood NGAL levels in neonatal groups 13,17,22) .…”

Section: Discussionmentioning

confidence: 99%

“…Compared with previous studies on newborn infants with AKI 13,17,20,22,28,29) , our study included a neonatal population in the late preterm period with a gestational age of 34-36 weeks. In addition, the AKI population of our study was composed of infants with mild AKI because all cases were classified as stage I AKI.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, it has been reported that blood NGAL level can help define AKI in various neonatal groups 13,17,20,22,28,29) . Jiang and Cui 28) performed a meta-analysis concerning the accuracy of using NGAL level in the diagnosis of AKI to clarify the definition of AKI.…”

Section: Discussionmentioning

confidence: 99%

“…To overcome such limitation in collecting urine sample, studies using blood NGAL measurement have been performed for several neonatal groups 13,17,22) . Recently, rapid plasma NGAL assay has provided clinicians an opportunity to explore its potential usefulness at bedside within 20 min.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Utility of Rapid Plasma Neutrophil Gelatinase-Associated Lipocalin Assays for Diagnosing Acute Kidney Injury in Critically Ill Newborn Infants

Chung

Choi

et al. 2017

Neonatal Med

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Purpose: Neutrophil gelatinase-associated lipocalin (NGAL) has been identified as an early marker of acute kidney injury (AKI). This study was designed to evaluate the clinical utility of the rapid plasma NGAL assay for diagnosing AKI in critically ill newborn infants in the neonatal intensive care unit (NICU). Methods: The medical records of 178 critically ill newborn infants >34 weeks of gestational age who underwent plasma NGAL measurement during the first week of life in the Korea University Ansan Hospital NICU from February 2011 to August 2015 were retrospectively reviewed. Plasma NGAL levels were measured at bedside by using a commercial competitive immunoassay kit simultaneously with serum crea tinine (Cr) level determination. Results: Of 178 newborn infants enrolled in this study (study group), 25 infants had AKI (AKI group) while 153 infants had no AKI (control group). The plasma NGAL level in the AKI group (114.0 [76.5-281.5] ng/mL) was significantly higher than that in the control group (74.0 [52.5-122.5] ng/mL, P=0.001). Moreover, plasma NGAL levels were found to be correlated with serum Cr levels in the study group (r=0.208, P= 0.005). Plasma NGAL achieved an area under the receiver operating characteristic curve of 0.705 for detecting AKI (95% confidence interval: 0.593-0.817). The best cutoff plasma NGAL level for AKI diagnosis was 100 ng/mL. Conclusion: The rapid plasma NGAL assay has diagnostic value for AKI in critically ill newborn infants >34 weeks of gestational age. Further investigations with a larger population are needed to confirm the potential use of plasma NGAL levels for diagnosing AKI in newborn infants.

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Neutrophil gelatinase-associated lipocalin as predictor of acute kidney injury in neonates with perinatal asphyxia: a systematic review and meta-analysis

et al. 2018

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Serum and urinary NGAL represent candidate biomarkers with high performance in the prediction of acute kidney injury in newborns with perinatal asphyxia. Before NGAL can be widely used in clinical practice, future large prospective studies are needed to define the optimal cutoffs and accurately determine which levels are suggestive of post-asphyxial acute kidney injury. What is Known: • Acute kidney injury is a major cause of morbidity and mortality in perinatal asphyxia. • Current markers are insufficient in predicting post-asphyxial acute kidney injury. What is New: • Area under the curve for serum and urinary neutrophil gelatinase-associated lipocalin is 0.818 and 0.899, respectively. • Neutrophil gelatinase-associated lipocalin is a useful marker for detecting asphyxiated neonates at risk of developing acute kidney injury.

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Serum neutrophil gelatinase-associated lipocalin as a marker of acute kidney injury in asphyxiated neonates

Abstract: Elevated serum NGAL measured within 6 hours after birth reliably indicates acute kidney injury in asphyxiated neonates.

Cited by 24 publications

References 14 publications

Clinical Utility of Serum Neutrophil Gelatinase Associated Lipocalin(NGAL) as an Early Marker of Acute Kidney Injury in Asphyxiated Neonates

Clinical Utility of Serum Neutrophil Gelatinase Associated Lipocalin(NGAL) as an Early Marker of Acute Kidney Injury in Asphyxiated Neonates

Clinical Utility of Rapid Plasma Neutrophil Gelatinase-Associated Lipocalin Assays for Diagnosing Acute Kidney Injury in Critically Ill Newborn Infants

Neutrophil gelatinase-associated lipocalin as predictor of acute kidney injury in neonates with perinatal asphyxia: a systematic review and meta-analysis

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