Neutrophil gelatinase-associated lipocalin as predictor of acute kidney injury in neonates with perinatal asphyxia: a systematic review and meta-analysis

Bellos, Ioannis; Fitrou, Georgia; Daskalakis, Georgios; Perrea, Despina; Pergialiotis, Vasilios

doi:10.1007/s00431-018-3221-z

Cited by 26 publications

(14 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AKI biomarkers in the urine have been shown to be predictive of AKI and mortality in children undergoing cardiopulmonary bypass [12] and in critically ill preterm infants [13]. Urinary neutrophil gelatinase-associated lipocalin (NGAL) has bacteriostatic properties and contributes to innate immunity [14]. At the early phase of ischemia-induced AKI there is a rapid upregulation of NGAL mRNA in the Henle loop and proximal tubules, causing an increase in the synthesis and excretion of NGAL into the urine.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Novel Biomarkers for Early Diagnosis of Acute Kidney Injury in Asphyxiated Full-Term Newborns: A Case-Control Study

Zhang

Wang

et al. 2019

Med Princ Pract

View full text Add to dashboard Cite

Significance of the Study• Previous studies have focused on urinary parameters, marker proteins or renal indices, but a holistic study combining all three has been rarely embarked upon. • We explored the individual and combined ability of serum cystatin C, beta 2-microglobulin, urinary neutrophil gelatinase-associated lipocalin, and alpha 1-microglobulin to predict acute kidney injury in asphyxiated neonates. • This study provides a reference for combined detection of renal injury after neonatal asphyxia. AbstractObjectives: To investigate the changes of serum cystatin C (Cys-C), beta 2-microglobulin (β2-MG), urinary neutrophil gelatinase-associated lipocalin (NGAL), and alpha 1-microglobulin (α1-MG) in asphyxiated neonates, and to evaluate the value of combined detection of multiple biomarkers in the early diagnosis of acute kidney injury (AKI) in asphyxiated neonates. Methods: A total of 110 full-term asphyxiated and 30 healthy neonates were included. The asphyxia neonates were divided into AKI and non-AKI groups. Serum Cys-C, β2-MG, urine NGAL, and α1-MG were measured 24 h after birth. The diagnostic value of the biomarkers was determined using receiver operating characteristic (ROC) curves. Results: There was no significant difference in serum creatinine and blood urea nitrogen among the control group, moderate asphyxia group, and severe asphyxia group at 24 h after birth. Significant differences were noticed in terms of serum Cys-C, β2-MG, urinary NGAL, and α1-MG among the 3 groups. Moreover, with the aggravation of asphyxia, the above indicators gradually increased. There were significant differences in the 4 indicators between the AKI and non-AKI groups (p < 0.05). The area under the ROC curve of the above indicators was 0.670, 0.689, 0.865, and 0.617, respectively (p < 0.05). The sensitivity and specificity of the combined diagnosis of asphyxia neonatorum AKI with the 4 indicators were 0.974 and 0.506, respectively. Conclusions: Serum Cys-C, β2-MG, urine NGAL, and α1-MG are early specific indicators for

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluation of Novel Biomarkers for Early Diagnosis of Acute Kidney Injury in Asphyxiated Full-Term Newborns: A Case-Control Study

Zhang

Wang

et al. 2019

Med Princ Pract

View full text Add to dashboard Cite

show abstract

“…Several studies described a correlation between uNGAL values and the severity of sepsis and asphyxia, even in the absence of associated AKI. Studies also describe a positive correlation between uNGAL values and inflammatory markers like C-reactive protein and procalcitonin [14,21]. Currently, uNGAL production associated with tubular injury (as a monomer) or with inflammatory or ischemic processes (as a dimer) cannot be technically differentiated.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil gelatinase-associated lipocalin distribution in preterm newborns without acute kidney injury as defined by a reference method

Mul

Parvex

Wilhelm-Bals

2021

The Journal of Maternal-Fetal & Neonatal Medicine

View full text Add to dashboard Cite

Introduction: Neutrophil gelatinase-associated lipocalin (NGAL) has been proposed as an early acute kidney injury (AKI) biomarker in the neonatal population. Our goal is to describe this biomarker behavior in this high-risk population, in absence of AKI as confirmed by inulin clearance. Materials and methods: Prospective study including 42 preterm newborns (mean gestational age: 30.7 ± 2.3 weeks) with a urinary NGAL collection between day 1 and 6 of life. Results: Median urinary neutrophil gelatinase-associated lipocalin (uNGAL) value is 122.8 ng/ml (7-1981.5 ng/ml). Statistically significant higher uNGAL values are found in female. uNGAL median values are decreasing when comparing extremely, very, and late preterm groups (812.2 ng/ml [75.

show abstract

“…NGAL is a newly identified adipokine that is highly expressed in cells from various pathological tissues with abnormal metabolism [39,40]. Many studies have shown that NGAL has a rapid elevation at blood levels during kidney injury, and its sensitivity for ischemic or nephrotoxic AKI is significantly higher than P r e p r i n t traditional kidney injury markers such as SCr and SUr [35,41,42]. Since its recommendation by the US FDA as a marker of renal function in 2002, CysC has been widely used in clinical applications because it is not affected by factors such as age, gender, and body weight inflammation.…”

Section: P R E P R I N Tmentioning

confidence: 99%

Clinical Evaluation of Serum Complement Component 1q and Cystatin C in the Diagnosis of Early Diabetic Kidney Disease

2021

View full text Add to dashboard Cite

IntroductionTo investigate the diagnostic value of serum complement components 1 q (C1q), neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (CysC), creatinine (SCr) and urea (SUr) for early diabetic kidney disease (EDKD)Material and methodsIndividuals with type 2 diabetes mellitus (DM) and healthy subjects at Mianyang Central Hospital from March, 2017 to November, 2017 were enrolled according to the inclusion and exclusion criteria. Serum SUr, SCr, CysC, C1q and NGAL were detected. Diagnostic values were evaluated by ROC.ResultsTotally, 546 individuals were enrolled, including 136 patients in simple DM group (SDM group), and 109 patients in EDKD group and 301 healthy controls (HC group). Compared with SDM group and HC group, serum SUr, SCr, C1q, CysC and NGAL in EDKD group were significantly increased (P<0.01). C1q, CysC, and NGAL were significantly related to EDKD and they were risk factors for EDKD. Diagnostic performance of CysC (AUC=0.813, 0.777~0.845), C1q (AUC=0.797, 0.761~0.830) or NGAL (AUC=0.770, 0.732~0.805) was much higher than that of SCr (AUC=0.681, 0.640~0.720) or SUr (AUC=0.650, 0.608~0.690) (p < 0.05). C1q +CysC (AUC=0.896, 0.867~0.920; Se=77.98%, 74.27% - 81.39%; Sp=89.4%, 86.59% - 91.92%; YI=0.675) had the optimal diagnostic performance. However, combination of C1q+CysC+NGAL (AUC=0.909, 0.882~0.932; Se=88.99%, 86.06% - 91.49%; Sp=80.32%, 76.73% - 83.57%; YI=0.693) or C1q+CysC+NGAL+SCr (AUC=0.912, 0.885~0.934; Se=87.16%, 84.06% - 89.85%; Sp=83.98%, 80.63% - 86.96%; YI=0.711) did not further improve diagnosis performance for EDKD (p>0.05).ConclusionsC1q, CysC and NGAL have similar diagnostic performances, which is superior to SCr, in diagnosis of EDKD. Moreover, C1q +CysC combination has the optimal diagnostic performance for EDKD.

show abstract

Neutrophil gelatinase-associated lipocalin as predictor of acute kidney injury in neonates with perinatal asphyxia: a systematic review and meta-analysis

Cited by 26 publications

References 50 publications

Evaluation of Novel Biomarkers for Early Diagnosis of Acute Kidney Injury in Asphyxiated Full-Term Newborns: A Case-Control Study

Evaluation of Novel Biomarkers for Early Diagnosis of Acute Kidney Injury in Asphyxiated Full-Term Newborns: A Case-Control Study

Neutrophil gelatinase-associated lipocalin distribution in preterm newborns without acute kidney injury as defined by a reference method

Clinical Evaluation of Serum Complement Component 1q and Cystatin C in the Diagnosis of Early Diabetic Kidney Disease

Contact Info

Product

Resources

About