Serum N-terminal-pro-brain natriuretic peptide (NT-pro-BNP) and homocysteine levels in type 2 diabetic patients with asymptomatic left ventricular diastolic dysfunction

Görmüş, Uzay; Özmen, Dilek; Özmen, Bilgin; Parildar, Zuhal; Özdoğan, Öner; Mutaf, Isil; Bayındır, Oya

doi:10.1016/j.diabres.2009.10.010

Cited by 20 publications

(13 citation statements)

References 31 publications

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“…Monitoring non-conventional risk biomarkers for PAD in T2DM may be particularly important for the prevention and treatment of PAD. BNP levels are known to be elevated in T2DM patients with asymptomatic diastolic dysfunction [23]. It has been acknowledged that subjects with higher BNP levels are more likely to have conventional cardiovascular risk factors (e.g., hypertension [24], ischemic stroke [25,26], and chronic kidney disease [27]).…”

Section: Discussionmentioning

confidence: 99%

Levels of brain natriuretic peptide are associated with peripheral arterial disease in subjects with type-2 diabetes mellitus

Chen

et al. 2014

BMC Endocr Disord

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BackgroundThe effects of brain natriuretic peptide (BNP) on the risk of cardiovascular disease and atherosclerosis have been studied. However, little information is available regarding peripheral arterial disease (PAD), particularly among subjects with type-2 diabetes mellitus (T2DM). The aim of our study was to assess the potential relationship between BNP levels and PAD among T2DM patients.MethodsThe study cohort was 507 T2DM outpatients in which BNP levels were measured. Cross-sectional associations between BNP levels (in tertiles) and PAD were examined.ResultsCompared withT2DM patients without PAD, BNP levels were markedly higher in patients with PAD (p = 0.001). Correlation analyses showed that the BNP level was negatively correlated with the ankle–brachial index (r = −0.453, p = 0.033). At a cutoff value of 78.2 pg/ml, the BNP level showed a sensitivity of 71.9%, a specificity of 68.1%, and a positive predictive value of 84.3% for a diagnosis of PAD. The area under the receiver-operating characteristic curve increased significantly if BNP levels were incorporated into a predictive model of the potential risk factors for PAD (0.85 vs 0.81, p = 0.029).ConclusionsBNP is a potential and promising biomarker for PAD screening in T2DM patients.

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Section: Discussionmentioning

confidence: 99%

Levels of brain natriuretic peptide are associated with peripheral arterial disease in subjects with type-2 diabetes mellitus

Chen

et al. 2014

BMC Endocr Disord

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“…Abnormalities in diastolic function are often misdiagnosed as this condition does not always produce signs and symptoms of HF, which leaves patients predisposed to symptomatic HF and cardiac necrosis due to the delay in treatment (31). The early diagnosis of LV diastolic dysfunction during its initial phase facilitates the initiation of effective treatment with the purpose of halting the progress of the disease and delaying the development of symptomatic HF (32). Echocardiography, using both Doppler measurements of transmitral and pulmonary vein blood flow velocities and tissue Doppler imaging, is a widely accepted method for the clinical analysis of diastole (33).…”

Section: Endpoint Events ----------------------------------------------mentioning

confidence: 99%

Correlation between brain natriuretic peptide levels and the prognosis of patients with left ventricular diastolic dysfunction

Gong

Wang

Shi

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The present study aimed to investigate the association between brain natriuretic peptide (BNP) levels and the prognosis of patients with left ventricular (LV) diastolic dysfunction. A total of 708 inpatients with cardiovascular disease (mean age, 66 years; 395 males and 313 females) were grouped according to initial BNP and were followed-up for 20-51 months (average, 30.86 months) until endpoint events occurred. Endpoints were defined as mortality or readmission due to cardiovascular disease, or mortality due to any other reason. A total of 67 and 77 events were reported in the BNP ≤80 pg/ml and BNP >80 pg/ml groups, respectively. The occurrence rate of the endpoint was significantly higher in the BNP >80 pg/ml group, as compared with the BNP ≤80 pg/ml group (26.28 vs. 16.14%; relative risk=1.63). Furthermore, the durations of patient survival were significantly shorter in the BNP >80 pg/ml group, as compared with the BNP ≤80 pg/ml group (P=0.0006), and patient survival decreased as BNP levels rose (P=0.0074). Among the 708 patients, 677 underwent echocardiographic detection at the same time. No significant correlation was detected between BNP levels and survival time in 178 patients with normal LV diastolic function [mitral Doppler flow, early diastolic (E)/late diastolic (A)>1] (P=0.2165); whereas a negative correlation was determined in 499 patients with LVD dysfunction (E/A≤1) (Spearman's rho=-0.0899; P=0.0447). The prognoses of patients with elevated BNP levels were correspondingly worse in the present study and these correlations were demonstrated to be significant in patients with LV diastolic dysfunction. Therefore, BNP levels may be used to predict the prognosis of patients with cardiovascular disease.

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“…Early diagnosis of LV diastolic dysfunction in an initial phase enables the start of effective treatment, which functions by stopping the progress of the disease and delaying the development of symptomatic HF (33). Analysis of the diastole by means of echocardiography, using Doppler measurements of transmitral and pulmonary vein blood flow velocities and tissue Doppler imaging, is widely accepted for clinical purposes (34). However, this type of assessment is expensive as it requires complex equipment, time-consuming as it involves the analysis of numerous variables and difficult as it must be performed by a skilled and trained operator (35).…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of brain natriuretic peptide in patients with heart failure and reserved left ventricular systolic function

Gong

Wang

Liu

et al. 2014

Experimental and Therapeutic Medicine

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Brain natriuretic peptide (BNP) is used as a prognostic biomarker for patients with heart failure (HF) in clinical practice, however, the correlation between BNP levels and the prognosis of HF in patients with reserved left ventricular systolic function (RLVSF) is not clear. Thus, the aim of the present study was to evaluate the added value of BNP in the prognosis of HF patients with RLVSF. Inpatients with cardiovascular disease (mean age, 65.7 years; male, 790; female, 625) admitted to the Division of Cardiology at Jinshan Hospital of Fudan University (Shanghai, China) between June 2006 and December 2009 underwent follow-up examinations. Plasma BNP levels were analyzed and measurements of the left ventricular ejection fraction (LVEF) were performed by echocardiography. Evaluations of the patients with HF were performed according to the New York Heart Association (NYHA) classification system. The duration of the follow-up period ranged between 21 and 63 months (average duration, 35.8 months) and key events included cardiovascular mortality, readmission due to cardiovascular disease or mortality due to other reasons. Survival times decreased with increasing BNP levels in all the follow-up patients (Spearman’s ρ, −0.1877; P<0.0001). Among the 1,415 patients, 1,312 underwent echocardiographic detection. A total of 395 patients with NYHA classes II–IV and a LVEF ≥45% were selected. The incidence of compound endpoint events was significantly higher in the patients that had BNP levels of >100 pg/ml when compared with the patients that had BNP levels of ≤100 pg/ml (37.07 vs. 23.93%; relative risk, 1.55); consequently the survival times were significantly reduced (P=0.0039). A negative correlation was identified between the BNP levels and the survival times in these patients (Spearman’s ρ, −0.1738; P=0.0005). These results indicated that the levels of BNP may be used to predict the prognosis of patients with cardiovascular disease. The prognoses of patients with higher BNP levels were worse compared with the patients with lower BNP levels. Furthermore, significant correlations were confirmed in the HF patients with RLVSF.

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Serum N-terminal-pro-brain natriuretic peptide (NT-pro-BNP) and homocysteine levels in type 2 diabetic patients with asymptomatic left ventricular diastolic dysfunction

Cited by 20 publications

References 31 publications

Levels of brain natriuretic peptide are associated with peripheral arterial disease in subjects with type-2 diabetes mellitus

Levels of brain natriuretic peptide are associated with peripheral arterial disease in subjects with type-2 diabetes mellitus

Correlation between brain natriuretic peptide levels and the prognosis of patients with left ventricular diastolic dysfunction

Prognostic value of brain natriuretic peptide in patients with heart failure and reserved left ventricular systolic function

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