Correlation between brain natriuretic peptide levels and the prognosis of patients with left ventricular diastolic dysfunction

Abstract

Abstract. The present study aimed to investigate the association between brain natriuretic peptide (BNP) levels and the prognosis of patients with left ventricular (LV) diastolic dysfunction. A total of 708 inpatients with cardiovascular disease (mean age, 66 years; 395 males and 313 females) were grouped according to initial BNP and were followed-up for 20-51 months (average, 30.86 months) until endpoint events occurred. Endpoints were defined as mortality or readmission due to cardiovascular disease, or mortality due to any other reason. A total of 67 and 77 events were reported in the BNP ≤80 pg/ml and BNP >80 pg/ml groups, respectively. The occurrence rate of the endpoint was significantly higher in the BNP >80 pg/ml group, as compared with the BNP ≤80 pg/ml group (26.28 vs. 16.14%; relative risk=1.63). Furthermore, the durations of patient survival were significantly shorter in the BNP >80 pg/ml group, as compared with the BNP ≤80 pg/ml group (P=0.0006), and patient survival decreased as BNP levels rose (P=0.0074). Among the 708 patients, 677 underwent echocardiographic detection at the same time. No significant correlation was detected between BNP levels and survival time in 178 patients with normal LV diastolic function [mitral Doppler flow, early diastolic (E)/late diastolic (A)>1] (P=0.2165); whereas a negative correlation was determined in 499 patients with LVD dysfunction (E/A≤1) (Spearman's rho=-0.0899; P=0.0447). The prognoses of patients with elevated BNP levels were correspondingly worse in the present study and these correlations were demonstrated to be significant in patients with LV diastolic dysfunction. Therefore, BNP levels may be used to predict the prognosis of patients with cardiovascular disease.

Brain Natriuretic Peptide as a Predictor of Major Adverse Cardiac Events after Successful Percutaneous Coronary Intervention

“…On the other hand there is statistically significant negative correlation between BNP level and EF after 3 months; which indicated that increase in BNP level will be associated with decrease in EF [P-value < 0.01], and there was statistically significant difference in BNP level between degree of diastolic dysfunction with high mean BNP level among grade II diastolic dysfunction at presentation and after 3 months follow up [P-value < 0.05]. These findings were consistent with the work done in 2016 in a study [18]; named, Correlation between brain natriuretic peptide levels and the prognosis of patients with left ventricular diastolic dysfunction; that enrolled 708 patients who were followed up for 20-51 months. Endpoints were defined as mortality or readmission due to cardiovascular disease, or mortality due to any other reason.…”

Use of Extracorporeal Life Support in Postpartum in a Patient with Amniotic Fluid Embolism Complicated by Left Ventricular Failure and Disseminated Intravascular Coagulopathy

“…Tanous, et al [17] explained that women with ventricular dysfunction correlates with high BNP during pregnancy. We postulate that her elevated BNP is attributed to renal impairment and persistently mild left ventricular impairement [18]. Long term prognosis for mortality, HF, and new ischemic events is described to be better stratified with a combination of NT ProBNP with LVEF [18,19].…”

Complexity analysis from EEG data in congestive heart failure: A study via approximate entropy

“…B‐type natriuretic peptides is a peptide that assumes a crucial role in CHF compensatory response. It is secreted by ventricular myocyte in response to left ventricular volume expansion and pressure overload 4 . Since plasma BNP concentration raises during CHF, it is usually used as a biomarker for the diagnosis of this cardiovascular disease 5,6 .…”

“…It is secreted by ventricular myocyte in response to left ventricular volume expansion and pressure overload. 4 Since plasma BNP concentration raises during CHF, it is usually used as a biomarker for the diagnosis of this cardiovascular disease. 5,6 More specifically, according to the European Society of Cardiology (ESC) a BNP value higher than 100 pg/mL reflects the occurrence of CHF.…”