Serum microRNA-1 and microRNA-122 are prognostic markers in patients with hepatocellular carcinoma

HepatomiRNoma: The proposal of a new network of targets for diagnosis, prognosis and therapy in hepatocellular carcinoma

“…This performance improves with progression disease (Xu et al, 2011a). For this reason, it has been demonstrated that miR-122 is negatively related to MELD score and necroinflammation (Koberle et al, 2013). The role in viral replication supported the hypothesis that the use of the vector plasmid pLMP-miR-122 on HepG2 cells promotes the inhibition of HBV replication (Huang and Liu, 2009).…”

“…Besides the vascular tone and vascular growth are stimulated through IGF-1 and 2, PDGF, and EGF. These properties have allowed us to identify serum miR-1 as potential prognostic factor in HCC as suggested by the study of Koberle et al (2013), since it is independent of the stage Barcelona Clinic Liver Cancer (BCLC), Cancer of the Liver Italian Program (CLIP) and treatment of tumors.…”

Genetic Factors, Viral Infection, Other Factors and Liver Cancer: An Update on Current Progress

“…Researchers (Burchard et al, 2010 conducted the study on the function of miR-122 and found that, miR-122 was significantly under-expressed in HCC and consequently the expression of miR-122 seed-matched genes was elevated. In additional, miR-122 can also serve as a parameter for survival among patients with HCC, the results generated by using TaqMan MiRNA assay indicated that patients with greater mi-R122 level have longer overall survival than those with lower miR-122 serum concentration with a hazard ratio of 0.440 (Köberle et al, 2013) . In vivo validation suggested that the loss if miR-122 alone can up-regulated seed-matched genes and down-regulated mitochondrially localized genes that are critical for metabolic functions.…”

Non-coding RNAs: New therapeutic targets and opportunities for hepatocellular carcinoma

“…Even though the miRNA fragment is very small, it is stable to some extent. Thus, more sensitive detection methods such as qRT-PCR can be used to detect its presence in serum or other body fluid specimens for disease diagnosis [11] . lncRNAs could be characterized by qRT-PCR, Northern blot analysis or in situ hybridization [63] .…”

“…Curative treatments, which are mostly surgical in nature (e.g., resection and liver transplantation), are suitable only during the early tumor stages. In the intermediate or advanced stages, curative options are often lacking [11,12] . Therefore, identifying effective biomarkers are very important for the diagnosis of HCC.…”