Genetic Factors, Viral Infection, Other Factors and Liver Cancer: An Update on Current Progress

Su, Chenghao; Yan, Lin; Cai, Lin

doi:10.7314/apjcp.2013.14.9.4953

Cited by 38 publications

(28 citation statements)

References 90 publications

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“…The causes of cancer are multiplex, complex, and only partially understood. At present, many things are known to increase the risk of cancer, including dietary factors, certain infections, other factors, genetic factors, exposure to radiation, lack of physical activity, and environmental pollutants (Su et al, 2013). However, CRC is cancer of the large intestine, the lower part of one's digestive system (Haggar et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Role of TGF-β1 in Human Colorectal Cancer and Effects after Cantharidinate Intervention

Gao²,

Hua³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Effects of transforming growth factor-beta (TGF-β) were investigated in human colorectal cancer, and the influence of cantharidinate in inhibiting TGF-β1 expression was explored. Relationships among TGF-β1 and sex, age, tumor size, tumor location, tumor stage were also analyzed. H&E and immunohistochemistry staining were employed to assess colorectal cancer and TGF-β1 expression, respectively. Then, HCT-116 CRC cells were randomly divided into four groups, controls, no serum-treated, chemotherapy and cantharidinate-treated. Immunohistochemistry and real-time PCR were employed to assess the expression of TGF-β1 in CRC cells. Our data showed that the expression of TGF-β1 might be associated with tumor size and tumor location (P﹤0.05). The expression of TGF-β1 in CRC groups was higher than in adjacent groups (P﹤0.05). In addition, the expression of TGF-β1 in cantharidinate-treated group was much lower than in CRC group (P﹤0.05). Taken together, these results suggest that TGF-β1 plays an important role in CRC development. Cantharidinate might inhibit the expression of TGF-β1 and control the development of colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

Role of TGF-β1 in Human Colorectal Cancer and Effects after Cantharidinate Intervention

Gao²,

Hua³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…The exact mechanisms driving hepatitisinduced HCC remain elusive. Among them, aberrant expression of cytotoxic cytokines is thought to be critically involved (Haybaeck et al, 2009;Su et al, 2013). The proinflammatory cytokines tumor necrosis factor (TNF) a, TNFβ, and lymphotoxin (LT) β are members of the TNF superfamily (Aggarwal et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Independent and Additive Interaction Between Tumor Necrosis Factor β +252 Polymorphisms and Chronic Hepatitis B and C Virus Infection on Risk and Prognosis of Hepatocellular Carcinoma: a Case-Control Study

Jeng

Wu²,

Tsai³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Genetic factors play a role in the higher occurrence and mortality of liver cancer in men than in women,[60] as well as the higher amount of alcohol consumed by men. [61] Aflatoxin exposure, unhealthy eating habits, polluted water, and blood transfusion are also risk factors of liver cancer, and people in rural areas are easily exposed to these risk factors.…”

Section: Cancer Health Disparitymentioning

confidence: 99%

Health disparity and cancer health disparity in China

Wang

Jiao

2016

Asia-Pacific Journal of Oncology Nursing

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China is one of the largest and most populated countries in the world. It has undergone rapid economic growth in recent years. However, the development is not equitable, and the distribution of wealth significantly varies among the regions in China. Geographical and socioeconomic inequalities, together with the lack of an equitable national social support system, cause the high variance of health outcomes among the regions. Furthermore, the fast growth of the economy has evoked many environmental challenges and puts much pressure on the population. The severe environmental deterioration, especially of the atmosphere and water bodies, has affected the health of the people living in China. As a result, cancer has become a major public health issue, and an alarming increase in incidence and mortality has been reported. However, cancer incidence and mortality vary in different areas in China. Cancer and cancer treatment disparities have existed for years. This article will discuss the existing health and cancer disparities associated with the risk factors and how these disparities are managed in China.

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Genetic Factors, Viral Infection, Other Factors and Liver Cancer: An Update on Current Progress

Cited by 38 publications

References 90 publications

Role of TGF-β1 in Human Colorectal Cancer and Effects after Cantharidinate Intervention

Role of TGF-β1 in Human Colorectal Cancer and Effects after Cantharidinate Intervention

Independent and Additive Interaction Between Tumor Necrosis Factor β +252 Polymorphisms and Chronic Hepatitis B and C Virus Infection on Risk and Prognosis of Hepatocellular Carcinoma: a Case-Control Study

Health disparity and cancer health disparity in China

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