Independent and Additive Interaction Between Tumor Necrosis Factor β +252 Polymorphisms and Chronic Hepatitis B and C Virus Infection on Risk and Prognosis of Hepatocellular Carcinoma: a Case-Control Study

Jeng, Jen‐Eing; Wu, Huifang; Tsai, Meng-Feng; Tsai, Huey-Ru; Chuang, Li‐Yeh; Lin, Zu‐Yau; Hsieh, Ming‐Yuh; Chen, Shinn‐Chern; Chuang, Wen-Li; Wang, Liang‐Yen; Yu, Ming‐Lung; Dai, Chia‐Yen; Tsai, Jung‐Fa

doi:10.7314/apjcp.2014.15.23.10209

Cited by 6 publications

(10 citation statements)

References 39 publications

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“…LTα is upregulated in hepatitis‐associated HCC [4,5]. Sustained LT signaling represents a pathway involved in liver carcinogenesis [4].…”

Section: Discussionmentioning

confidence: 99%

“…The genotypes of LTα +252 G/G genotypes (rs909253) were determined by polymerase chain reaction with restriction fragment length polymorphism, as methods reported previously [5].…”

Section: Methodsmentioning

confidence: 99%

“…HCC is inherently associated with up‐regulation of cytokines including tumor necrosis α (TNFα) and lymphotoxin α (LT α ) [3,4]. Previously, we reported that single nucleotide polymorphism (SNP) of LTα +252 G/G is a risk factor for HCC [5].…”

Section: Introductionmentioning

confidence: 99%

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Interactive effects between Lymphotoxin α +252 polymorphism and habits of substance use on risk of hepatocellular carcinoma

Tsai

Chen

Lin

et al. 2017

The Kaohsiung J of Med Scie

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“…LTα is upregulated in hepatitis‐associated HCC [4,5]. Sustained LT signaling represents a pathway involved in liver carcinogenesis [4].…”

Section: Discussionmentioning

confidence: 99%

“…The genotypes of LTα +252 G/G genotypes (rs909253) were determined by polymerase chain reaction with restriction fragment length polymorphism, as methods reported previously [5].…”

Section: Methodsmentioning

confidence: 99%

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Interactive effects between Lymphotoxin α +252 polymorphism and habits of substance use on risk of hepatocellular carcinoma

Tsai

Chen

Lin

et al. 2017

The Kaohsiung J of Med Scie

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“…It is relevant to mention that there are no reported studies investigating the TNF-b gene polymorphism at position +252 in dengue virus-infected patients, but this polymorphism has been associated with hepatitis B and hepatitis C virus infections (37) and noninfectious diseases, such as multiple sclerosis, systemic lupus erythematosus, and acute ischemic stroke (1,21,41).…”

mentioning

confidence: 99%

Gene Polymorphisms and Serum Levels of Pro- and Anti-Inflammatory Markers in Dengue Viral Infections

et al. 2016

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Pro- and anti-inflammatory markers (tumor necrosis factor [TNF]-α, TNF-β, interferon [IFN]-γ, interleukin [IL]-6, IL-8, IL-10, and C-reactive protein [CRP]) were investigated in 80 patients infected with dengue viruses, 100 patients presenting with febrile illness but negative for dengue, and 99 healthy subjects. Immunoenzyme methods were used for quantitative assays in the plasma. Polymorphisms of TNF-α, TNF-β, IL-6, IL-8, and IL-10 genes were assessed by polymerase chain reaction (PCR)-restriction fragment length polymorphism and allele-specific oligonucleotide (ASO)-PCR for the IFN-γ. The highest mean serum levels of TNF-α, IFN-γ, IL-8, and CRP were observed in dengue-positive individuals. TNF-β, IL-6, and IL-10 levels were significantly higher in the dengue-negative individuals. No cytokine expression pattern was evidenced according to virus serotype. Genotypic frequency distributions were statistically significant for the polymorphisms of TNF-α and IFN-γ among positive, negative, and control dengue groups and IFN-γ among groups DENV-1, DENV-2, DENV-3, and controls. Modulation of cytokine expression and polymorphisms is a complex matter and needs further explanation considering the ethnic origins of the Brazilian population.

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“…Meanwhile, it is generally accepted that a SNP at position 252 in the intron of TNF-β called TNF-β 252A/G polymorphism leads to the overexpression of TNF-β, and it is considered a candidate biomarker of gastric cancer susceptibility [ 54 ]. Due to the function of TNF-β 252A/G polymorphism in many diseases [ 54 – 56 ], the relationship between TNF-β 252A/G polymorphism and OS susceptibility has also been determined [ 26 , 37 ]. Oliveira ID et al [ 26 ] studied TNF-β 252A/G polymorphism in 80 osteosarcoma patients and 160 control individuals using polymerase chain reaction-restriction fragment length polymorphism method.…”

Section: Discussionmentioning

confidence: 99%

Associations between inflammatory gene polymorphisms (TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G, TGF-β1 29T/C, IL-6 174G/C and IL-10 1082A/G) and susceptibility to osteosarcoma: a meta-analysis and literature review

et al. 2017

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Associations between inflammatory gene polymorphisms (TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G, TGF-β1 29T/C, IL-6 174G/C and IL-10 1082A/G) and osteosarcoma (OS) risk remain unclear. We conducted a systematic search to retrieve studies that investigated associations between inflammatory gene polymorphisms and OS risk. Nine studies that met the inclusion criteria were finally recruited in this meta-analysis. Overall, there was a significant association between TNF-α 308G/A, IL-10 1082A/G and OS risk, while there was no significant association between TNF-α 238G/A, TNF-β 252A/G and IL-6 174G/C and OS risk. Our subgroup analysis showed a significant association between IL-6 174G/C and IL-10 1082A/G and OS risk in Asians, while no such significant correlation was observed with TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G and TGF-β1 29T/C polymorphisms. In Caucasians, there was a significant association between TNF-α 238G/A and the decreased incidence of OS. In conclusion, inflammatory gene polymorphisms play a key role in the occurrence and progression of OS. IL-6 174G/C polymorphism was obviously associated with OS risk in Asians, while TNF-α 238G/A polymorphism seemed to be associated with the decreased susceptibility to OS in Caucasians as Altman and Bland test indicated. Although controversial results were observed between IL-10 1082A/G and OS risk in Asians and Caucasians, it is difficult to make a definite conclusion about the role of IL-10 1082A/G polymorphism in the etiology of OS because our Altman and Bland test showed no good evidence to support a different effect in Asians and Caucasians.

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Independent and Additive Interaction Between Tumor Necrosis Factor β +252 Polymorphisms and Chronic Hepatitis B and C Virus Infection on Risk and Prognosis of Hepatocellular Carcinoma: a Case-Control Study

Cited by 6 publications

References 39 publications

Interactive effects between Lymphotoxin α +252 polymorphism and habits of substance use on risk of hepatocellular carcinoma

Interactive effects between Lymphotoxin α +252 polymorphism and habits of substance use on risk of hepatocellular carcinoma

Gene Polymorphisms and Serum Levels of Pro- and Anti-Inflammatory Markers in Dengue Viral Infections

Associations between inflammatory gene polymorphisms (TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G, TGF-β1 29T/C, IL-6 174G/C and IL-10 1082A/G) and susceptibility to osteosarcoma: a meta-analysis and literature review

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