Serum microRNAs as potential biomarkers of mandibular prognathism

Abstract

Let-7i-3p and miR-595 could be potential, non-invasive biomarkers for the accurate early detection and diagnosis of MP, which may result in improved clinical management.

Expression profile of plasma microRNAs in nonsyndromic cleft lip and their clinical significance as biomarkers

“…A study reported that miR-16-2-3p was significantly upregulated in whole blood samples in multiple sclerosis [25], demonstrating its critical role in immunity development, which was involved in cleft lip [26]. Whereas serum miR-16-2-3p was validated to be not significantly associated with mandibular prognathism [10], suggesting that miR-16-2-3p may be specifically related with lip development.…”

“…Additionally, miRNA also circulates in serum and plasma. Disease-specific plasma or serum miRNA has been validated to have the ability to diagnose cancer, diabetes, and other diseases in advance, especially oral cancers [9][10][11][12][13]. We hypothesized that specific differentially expressed plasma miRNAs may help to monitor the pathophysiology of CL, and in this pilot study, the feasibility of using plasma miRNAs as potential non-invasive diagnostic biomarkers for CL in infants and the possible regulatory roles of plasma miRNAs in CL pathogenesis are examined.…”

MicroRNA expression profile of surgical removed mandibular bone tissues from patients with mandibular prognathism

“…The expression levels of four upregulated and two downregulated miRNAs were confirmed via quantitative real-time PCR, and the results were coincident with the prior microarray data. Gu et al [23] have found that three miRNAs (miR-367-5p, let-7i-3p, and miR-3142) were significantly upregulated, whereas eight miRNAs (such as miR-16-2-3p and miR-369-3p, and so forth) were markedly downregulated in the serum of MP patients. After a thorough comparison, we found that our results were hardly overlapped with theirs.…”

“…Current researches have revealed crucial roles of miRNAs in a broad range of organs in normal physiological contexts as well as in disease contexts, including heart [15,16], liver [15,17], lung [18,19], kidney [20], pancreas [21,22], and so forth. Interestingly, an earlier study has illustrated that circulating serum miRNAs, let-7i-3p and miR-595 can be used as potential biomarkers for MP in Chinese juveniles [23], suggesting miRNAs may be implicated in the pathogenesis of MP. Nevertheless, the association between MP development and miRNA regulation is still poorly understood and requires further investigation.…”

Phenotypic characterization of new mouse model of class III malocclusion

“…2,3 Over years, literature was focusing on studying mandibular prognathism as a main pattern of Class III malocclusion, however the reduction of midface prominence gives the typical appearance of concave profile. [4][5][6] Craniosynostosis of facial sutures is one of main causes of midface hypoplasia. 7 Midfacial hypoplasia represents an essential sign among signs and symptoms of syndromes characterized by craniosynostosis such as Apart and Pfeiffer syndromes.…”