Phenotypic characterization of new mouse model of class III malocclusion

Abstract

Many factors are contributing in the development of Class III malocclusion, and these factors are interacting inbetween during the craniofacial morphogenesis affecting the development and growth of nasomaxillary complex as well as the Mandible. The aim of this study was to characterize new mouse model of Class III malocclusion. Sixteen mutants (Sofa) and twelve controls were imaged by micro-computed tomography. The three dimensional models of the mice were phenotypically characterized. The mutation was expressed phenotypically in the form of midface deficiency, and anomalies in cranial sutures as well as synchondroses. Sofa mutants are likely to be used in future as model of mid face deficiency and Class III malocclusion.