Serum methylglyoxal level and its association with oxidative stress and disease severity in patients with psoriasis

Abstract

Psoriasis vulgaris (PV), a chronic inflammatory skin disease, is a condition of increased oxidative stress (OxS). However, interest related to oxidative and carbonyl stress damages to proteins, such as the formation of advanced glycation end products (AGEs) and their precursor molecule methylglyoxal (MG) has been modest. The objective of this study was to compare the systemic levels of OxS markers in patients with PV and healthy controls (Co) and to investigate their correlation with the serum level of MG. Total peroxide concentration (TPX) and total antioxidant capacity (TAC) were estimated by means of spectrophotometry. The TPX and TAC ratio was regarded as OxS index (OSI). MG level was determined using ELISA. Compared to Co, patients with PV had significantly increased blood levels of TPX (P < 0.0001), OSI (P < 0.0001), and MG (P = 0.01), and lower TAC levels (P < 0.0001). Increase in body mass index (BMI) appeared to contribute to this imbalance as TAC levels decreased with increasing BMI (r = -0.252, P < 0.01). Increased TPX concentration was associated with higher serum level of MG (r = 0.610, P = 0.004), the latter being positively correlated with psoriasis area and severity index (r = 0.577, P = 0.008). In performed multivariate regression analysis, TPX, TAC, and OSI were all significant predictors of MG level. Our study gave further proof of increased systemic psoriasis-related OxS. MG serum level, reflecting simultaneously OxS as well as carbonyl stress status, could be used as a marker of disease activity in clinical trials while looking for new systemic therapies for psoriasis.

Neuroprotective and anti‐apoptotic effects of liraglutide on SH‐SY5Y cells exposed to methylglyoxal stress

“…; Kaur et al . ). As the energy metabolism and glucose utilisation is compromised in the brain of Alzheimer patients (Hoyer ; Mattson ), the MG stress is a suitable tool to investigate the protective effects of GLP‐1 analogues.…”

“…Methylglyoxal (MG), a metabolic by-product of glycolysis and has serious toxicological effects when in excess. It interferes with cell energy metabolism, increases oxidative stress and enhances the formation of advanced glycation end products (AGE) (van Eupen et al 2013;Kaur et al 2013). As the energy metabolism and glucose utilisation is compromised in the brain of Alzheimer patients (Hoyer 2004;Mattson 2012), the MG stress is a suitable tool to investigate the protective effects of GLP-1 analogues.…”

Edaravone Protects against Methylglyoxal-Induced Barrier Damage in Human Brain Endothelial Cells

“…Increased serum levels of reactive carbonyl species, such as methylglyoxal, are present in several pathologies and cause complications in severe conditions and diseases, like diabetes mellitus [1], [2], cardiovascular diseases [3], [4], atherosclerosis [5], hypertension [6], metabolic syndrome [7], obesity [8], psoriasis [9], aging [10], [11] Alzheimer’s disease [12] [13], dementias [14], and other neurobiological diseases [15]. Methylglyoxal is a highly reactive α-oxoaldehyde with strong oxidant and glycation properties [16].…”

State of free-radical processes and antioxidant defence of patients with psoriasis and concomitant essential hypertension

“…With all advantages of methods for determination of lipid peroxidation it is shown that after several minutes LPO products are subject to detoxication in contrast to them the oxidized proteins can be kept in cells for hours and even days. All above mentioned facts permit to consider change of oxidative level and modifi ed proteins and their products (carbonyl groups) as the most stable and perspective markers which refl ect intensity of free-radical processes and oxidative stress in case of comorbid pathology such as psoriasis and essential hypertension [24].…”