Objective: to study the status of free-radical processes and antioxidant protection parameters in patients with psoriasis and concomitant essential hypertension.Materials and methods. Study of oxidative status was performed in 95 patients who were divided into 3 groups: I group -psoriasis and hypertension -25 people; II group -30 patients with psoriasis only and group III -40 patients with hypertension only. To assess the severity of skin lesions in psoriasis the index Psoriasis Area and Severity Index (PASI) were used. Protein oxidative destruction markersaldehydephenilhydrazones and ketophenylhydrazones -were determined under method of B. Halliwell.Results. Processes of carbonyl stress in the surveyed patients were studied taking into account the level of thiol-disulfi de balance. Both spontaneous and stimulated aldehyde phenylhydrazone were the lowest in patients with essential hypertension, in patients with psoriasis and essential hypertension the studied indicators were higher by 75.35 and 22.03 % (p<0.05) respectively, in patients with psoriasis -by 123.94 and 47.55 % (p<0.05), respectively, than in case of hypertension. Increase of spontaneous and stimulated ketone phenylhydrazone has also been observed in the main group. In case of psoriasis without essential hypertension the considered indicators exceed the respective values of persons with essential hypertension by 123 and 64.16 % (p<0.05), respectively, with the presence of essential hypertension -the difference with essential hypertension was only 67.83 and 28.32 % (p<0.05), respectively. So, patients with psoriasis and essential hypertension had more obvious changes of indicators stipulating the progressive increase of carbonyl stress processes.Conclusions. Thus, patients with combined pathology -psoriasis and essential hypertension -have development of oxidative and carbonyl stresses which signifi cantly shift thiol-disulfi de balance toward oxidized thiols.Obtained results showed the activation of oxidative stress in case of the studied comorbid pathology and also complex and ambiguous system of regulation of pro-and antioxidant balance which are presented by increase of free-radical oxidation activity and decrease of physiological antioxidant defence.Стан вільно-радикальних процесів і параметрів антиоксидантного захисту в пацієнтів, які хворі на псоріаз у поєднанні з гіпертонічною хворобою В. А. Візір, Г. І. Макуріна Мета роботи -вивчення стану вільно-радикальних процесів і параметрів антиоксидантного захисту у хворих на псоріаз із супут-ньою гіпертонічною хворобою.Матеріали та методи. Вивчили оксидативний стан у 95 пацієнтів, які були поділені на 3 групи: І -псоріаз і гіпертонічна хвороба (25 осіб); ІІ група -пацієнти лише із псоріазом (30 осіб) і III група -пацієнти лише з гіпертонічною хворобою (40 осіб). Для оціню-вання тяжкості ураження шкіри при псоріазі використовували Psoriasis Area and Severity Index (PASI). Визначення маркерів окисної деструкції білків -альдегідфенілгідразонів та кетонфенілгідразонів -здійснювали за методом B. Halliwell...
Objective. To study the clinical significance of oxidative processes modulation within frames of 2-ethyl-6-methyl-3-hydroxypyridine succinate dermatropic efficiency assessment in patients with psoriasis affected by arterial hypertension.Materials and methods. The results of this study are based on data of comprehensive examination and supervision of 30 patients suffering from psoriasis with different clinical forms such as normal levels of blood pressure (the control group) or in combination with hypertension (the study group).Results. The comparative description of the antioxidative therapy efficiency was performed by the end of treatment. The findings showed significantly positive antioxidant-dependent mechanisms of 2-ethyl-6-methyl-3-hydroxypyridine succinate clinical efficiency in patients with psoriasis affected by arterial hypertension.In case of patients with combined psoriasis and essential hypertension course 2-ethyl-6-methyl-3-hydroxypyridine succinate therapy caused reliable decrease of free-radical oxidation intensification in particular nitrosative (reliable decrease of nitrotyrosine) and oxidative (negative dynamics of endothelin-1 and positive dynamics as to glutathione metabolism) stresses. That, in its turn, decreased the evidence of apoptotic and inflammatory processes (caspase-8 and TNF-α regress) both directly and indirectly by means of mediating anti-inflammatory effect on endothelium cells and macrophages of anticoagulant proteinase through endothelial protein C receptor (EPCR) with production of components and structures of extracellular matrix and disturbance of microcirculation. Thus, it determines the key pathogenetic aspects of psoriasis. The decrease of VEGF expression indicators level (vascular endothelial growth factor) and serotonin, associated with this combined therapy, had stipulated statistically significant positive clinical and subjective effect in form of regress of dermatological changes (PASI index), decrease of itch (optimization of serotonin biosynthesis and reduction of methionine conversion (with homocysteine formation)) and improvement of life quality.Conclusions. Taking into account potential influence of 2-ethyl-6-methyl-3-hydroxypyridine succinate on these pathophysiological predictors and pathogenesis, which are to some extent involved in formation and progression of psoriatic disease, use of 2-ethyl-6-methyl-3-hydroxypyridine succinate is sufficiently effective in conditions of psoriasis therapy optimization. Zaporozhye medical journal 2016; №5 (98): 31-38Клінічна ефективність і дермопротекція 2-етил-6-метил-3-гідроксипіридину сукцинату при псоріазі: погляд із позицій антиоксидації В. А. Візір, Г. І. МакурінаРекомендації щодо терапії пацієнтів, які страждають одночасно на псоріаз та артеріальну гіпертензію, вкрай нечисленні. Мета роботи -вивчити клінічну значущість модуляції оксидативних процесів у рамках оцінювання дерматотропної ефективності 2-етил-6-метил-3-гідроксипіридину сукцинату у хворих на псоріаз на тлі артеріальної гіпертензії.Матеріали та методи. Резу...
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